Cholesterol News and Research

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Cholesterol is a waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid.

Higher HMBGB1 levels associated with obesity, inflammation, and cardiovascular disease in younger black adults

A "danger molecule" is higher in the blood of younger black adults than whites, females than males and increases with weight and age, researchers report in the first large, longitudinal study associating circulating HMGB1 levels with obesity, inflammation promoters and early indicators of cardiovascular risk in humans.

9 Oct 2020

High-intensity interval training benefits older people

Five years of high-intensity interval training increased quality of life, improved fitness and might very well have extended the lives of participants in the Generation 100 study.

8 Oct 2020

Using GWAS and trans-ancestry comparison to accurately predict risk for coronary artery disease

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences have used a combination of genome-wide association analysis--or GWAS--and a trans-ancestry comparison of different GWAS studies, to come up with a more accurate predictor of coronary artery disease based on genetic factors.

6 Oct 2020

Genetic risk scoring of lipoprotein(a) can predict risk of atherosclerotic cardiovascular disease

Elevated levels of a little-known lipoprotein in the blood that may put people at high risk of cardiovascular disease can be as accurately detected by genetic testing as by conventional laboratory measurement, researchers at Massachusetts General Hospital (MGH) have found.

6 Oct 2020

Multi-ancestry comparison can accurately predict risk factors for coronary artery disease

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences have used a combination of genome-wide association analysis—or GWAS—and a trans-ancestry comparison of different GWAS studies, to come up with a more accurate predictor of coronary artery disease based on genetic factors.

6 Oct 2020

Plasma ACE2 concentration associated with increased risk of major cardiovascular events

A team of scientists at the Population Health Research Institute, Hamilton Health Sciences, and McMaster University, Hamilton, in Ontario, Canada, revealed that increased plasma ACE2 levels in the blood could indicate a higher risk of major cardiovascular events. The study is published in the journal The Lancet.

6 Oct 2020

Higher vitamin D levels in pregnancy may protect children from developing high blood pressure

Children appear to be at greater risk of having high blood pressure when their mothers had the high blood pressure condition called preeclampsia during pregnancy--but this adverse association may be reduced or even eliminated for children who were exposed to higher levels of vitamin D in the womb, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

6 Oct 2020

Sebum changes in COVID-19 patients, for future testing and prognosis

Now, a new study published on the preprint server medRxiv in September 2020 shows that sebum lipids change in COVID-19. This could help develop a cheap and straightforward method of non-invasive diagnosis.

5 Oct 2020

Vitamin D deficiency during early development can influence metabolic health

Using a zebrafish model, researchers from North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumulation.

29 Sep 2020

ACD study underscores the prevalence of malnutrition among obese individuals

A new editorial accompanying a study published in the Journal of the American College of Cardiology is bringing attention to the underappreciated and often overlooked issue of malnutrition among those who are obese.

29 Sep 2020

Study shows clear links between genetic predisposition of CVD and lifestyle factors

From Weight Watchers to wearable tech – wherever we look, there are messages encouraging us to stay fit and healthy.

28 Sep 2020

CRISPR screening identifies human host pathways that facilitate coronavirus infection

The human coronavirus family consists of 7 known pathogens, for which there are no approved vaccines or specific therapeutic options. Although the seasonal human coronaviruses - OC43, HKU1, 229E, and NL63 – only cause mild respiratory infections, three highly pathogenic coronaviruses that emerged in the last two decades revealed the pandemic potential of this family of viruses.

27 Sep 2020

Research sheds light on how membrane proteins could be influenced by lipid environments

The cell membrane, the wall-like boundary between the cell interior and its outside environment, is primarily made up of two kinds of biomolecules: lipids and proteins. Different

24 Sep 2020

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Gruthan Bioscience, LLC, a Medical University of South Carolina startup based in Charleston, South Carolina, received a Small Business technology Transfer (STTR) award from the National Heart, Blood and Lung Institute in August to take the next step in developing a novel class of cholesterol-lowering drugs to treat familial hypercholesterolemia.

24 Sep 2020

Study: 5 to 10% of surgically induced weight loss linked with cardiovascular benefits

A Cleveland Clinic study shows that 5 to 10 percent of surgically induced weight loss is associated with improved life expectancy and cardiovascular health.

23 Sep 2020

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Using bioinformatics approaches, researchers have identified genes and pathways shared among patients with comorbidities and having severe COVID-19. The research is published on the preprint server bioRxiv in September 2020.

23 Sep 2020

Inhibition of SARS-CoV-2 with antisense oligonucleotides

A part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA is highly conserved. Researchers have used this as a target for designing antisense oligonucleotide gapmers to cleave the RNA and disrupt virus replication. Their research is published as a preprint on the online server bioRxiv in September 2020.

22 Sep 2020

Genomic adaptations to rice‐based diets contribute to mitigation of metabolic risk

The traditional rice-based diet of some east-Asian population has brought to a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity.

21 Sep 2020

Combined use of three drugs linked with lower lung cancer incidence and mortality

Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology.

17 Sep 2020

Better heart health linked to lower risk of developing hypertension in middle-aged adults

Better heart health, as measured by the American Heart Association's Life's Simple 7 (LS7) scale, was associated with a significantly lower risk of developing high blood pressure (also known as hypertension) in middle-aged, Black and white adults, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

16 Sep 2020

Cholesterol News and Research

Further Reading

Higher HMBGB1 levels associated with obesity, inflammation, and cardiovascular disease in younger black adults

High-intensity interval training benefits older people

Using GWAS and trans-ancestry comparison to accurately predict risk for coronary artery disease

Genetic risk scoring of lipoprotein(a) can predict risk of atherosclerotic cardiovascular disease

Multi-ancestry comparison can accurately predict risk factors for coronary artery disease

Plasma ACE2 concentration associated with increased risk of major cardiovascular events

Higher vitamin D levels in pregnancy may protect children from developing high blood pressure

Sebum changes in COVID-19 patients, for future testing and prognosis

Vitamin D deficiency during early development can influence metabolic health

ACD study underscores the prevalence of malnutrition among obese individuals

Study shows clear links between genetic predisposition of CVD and lifestyle factors

CRISPR screening identifies human host pathways that facilitate coronavirus infection

Research sheds light on how membrane proteins could be influenced by lipid environments

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Study: 5 to 10% of surgically induced weight loss linked with cardiovascular benefits

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Inhibition of SARS-CoV-2 with antisense oligonucleotides

Genomic adaptations to rice‐based diets contribute to mitigation of metabolic risk

Combined use of three drugs linked with lower lung cancer incidence and mortality

Better heart health linked to lower risk of developing hypertension in middle-aged adults

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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