Preclinical News and Research

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3D-printed tumors potentially next step in personalized medicine

Scientists at Tel Aviv University have successfully printed an entire active and viable brain tumor using a three-dimensional or 3D printer for the first time.

20 Aug 2021

Study in dogs may lead to better understanding of how gliomas affect the immune system

A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas.

20 Aug 2021

Study shows how mesenchymal stromal cells regulate factors driving inflammation in COPD patients

A new phase I clinical study shows, for the first time, how treatment with a type of stem cell called mesenchymal stromal cells is able to regulate important factors driving inflammation in patients with chronic obstructive pulmonary disease (COPD) for a period for time.

18 Aug 2021

Study reveals how high dietary fructose increases rates of obesity and cancers

Eating fructose appears to alter cells in the digestive tract in a way that enables it to take in more nutrients, according to a preclinical study from investigators at Weill Cornell Medicine and NewYork-Presbyterian.

18 Aug 2021

ELRIG UK Announces Drug Discovery 2021 Event to Host SLAS’s Innovation AveNEW

The European Laboratory Research & Innovation Group today announced the programme details for Drug Discovery 2021.

From Society for Laboratory Automation and Screening (SLAS) 18 Aug 2021

New bioengineered lung model could help scientists to advance research in lung conditions

An interdisciplinary team of researchers from McMaster and SickKids are developing a cutting-edge lung model that can better respond to viruses and drug treatments, giving scientists a tool to advance research in lung conditions like COVID-19, cystic fibrosis and allergens for asthma and air pollution.

18 Aug 2021

ERS Genomics and Cellular Engineering Technologies Enter CRISPR/Cas9 License Agreement

ERS Genomics Limited and Cellular Engineering Technologies today announced a non-exclusive license agreement.

17 Aug 2021

Data reinforces SAB-185’s potential to neutralize SARS-CoV-2 variants

A study, available on the pre-print server bioRxiv*, evaluated the neutralizing capacity of a fully human polyclonal antibody (SAB-185) against the Delta, Kappa, and Lambda variants using a lentiviral-based pseudovirus assay.

17 Aug 2021

Sphingolipid profile could predict severity of heart disease in African American patients with lupus

A team of researchers at the Medical University of South Carolina report in Frontiers in Immunology that they have identified a type of fat known as a sphingolipid that could predict the severity of heart disease in African American patients with lupus.

16 Aug 2021

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center, Bloomberg~Kimmel Institute for Cancer Immunotherapy and several other centers including University of Pittsburgh Cancer Institute, Yale Cancer Center and City of Hope in Los Angeles, which participated in study enrollment, and the University of Southern California and University College Cork in Ireland, which collaborated on analysis of the data.

16 Aug 2021

Biomedical scientists need to do more to improve the relevance, reproducibility of cell culture research

There is an urgent need for reporting of biomedical research on mammalian cells to be more standardized and detailed and for greater control and measurement of the environmental conditions of cell cultures.

13 Aug 2021

Advances in plant-made vaccines revive interest in plant-produced pharmaceuticals and edible drugs

Recent progress in developing and testing plant-made vaccines has revived interest in plant-produced pharmaceuticals, including edible drugs, for human use. Advances in technology and manufacturing could boost the uptake of therapeutics made in this way, say Hugues Fausther-Bovendo and Gary Kobinger in this Perspective.

13 Aug 2021

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue.

12 Aug 2021

Study identifies Foxo1 gene as a potential treatment target for hereditary lymphedema

A University of South Florida preclinical study unexpectedly identified the gene Foxo1 as a potential treatment target for hereditary lymphedema.

10 Aug 2021

Children's Hospital Colorado announces participation in pivotal trial of synthetic restorative pulmonary valve

Children's Hospital Colorado today announced it has joined the Xplore2/Pivotal trial, and is actively enrolling patients for the first-ever pivotal trial of a synthetic restorative pulmonary valve.

9 Aug 2021

New biocompatible glue could quickly seal injured tissues and stop bleeding

Inspired by the sticky substance that barnacles use to cling to rocks, MIT engineers have designed a strong, biocompatible glue that can seal injured tissues and stop bleeding.

9 Aug 2021

Scientists identify calpeptin as potential inhibitor of SARS-CoV-2

A team of US-based scientists has recently conducted a robust high-throughput screening to identify potential entry inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The screening identifies calpeptin as a potent and highly specific inhibitor of SARS-CoV-2 and its variants. The study is currently available on the bioRxiv* preprint server.

9 Aug 2021

Preclinical News and Research

3D-printed tumors potentially next step in personalized medicine

Study in dogs may lead to better understanding of how gliomas affect the immune system

Study shows how mesenchymal stromal cells regulate factors driving inflammation in COPD patients

Study reveals how high dietary fructose increases rates of obesity and cancers

ELRIG UK Announces Drug Discovery 2021 Event to Host SLAS’s Innovation AveNEW

New bioengineered lung model could help scientists to advance research in lung conditions

ERS Genomics and Cellular Engineering Technologies Enter CRISPR/Cas9 License Agreement

Data reinforces SAB-185’s potential to neutralize SARS-CoV-2 variants

Sphingolipid profile could predict severity of heart disease in African American patients with lupus

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Biomedical scientists need to do more to improve the relevance, reproducibility of cell culture research

Advances in plant-made vaccines revive interest in plant-produced pharmaceuticals and edible drugs

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Study identifies Foxo1 gene as a potential treatment target for hereditary lymphedema

Children's Hospital Colorado announces participation in pivotal trial of synthetic restorative pulmonary valve

New biocompatible glue could quickly seal injured tissues and stop bleeding

Scientists identify calpeptin as potential inhibitor of SARS-CoV-2

Researchers create new model for studying earliest stages of retinoblastoma

Heterologous prime-boost vaccination induces robust mucosal and systemic immunity against SARS-CoV-2

Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

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