Biochemistry News and Research

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Unique mechanism of drug resistance found in pandemic cholera

Cholera is a devastating disease for millions worldwide, primarily in developing countries, and the dominant type of cholera today is naturally resistant to one type of antibiotic usually used as a treatment of last resort.

3 Jan 2018

Novel drug shows promise in treating metastatic kidney cancer

Metastatic kidney cancer remains largely incurable. Despite a dozen treatments and several immunotherapies, survival rates beyond 5 years remain around 10 percent.

21 Dec 2017

FDA-approved drug to treat high blood pressure increases life span in worms

UT Southwestern Medical Center researchers find that an FDA-approved drug to treat high blood pressure seems to extend lifespan in worms via a cell signaling pathway that may mimic caloric restriction.

21 Dec 2017

Epigenetics: A New Tool for Forensic Detectives

Developing analytical methods can help the triers of fact, judges and juries, better understand the events surrounding the circumstances of a crime. In forensic analysis, we are talking about determining the identity of unknown individuals through DNA and using DNA and other chemical signatures to determine and clarify the circumstances of the crime.

From Pittcon 20 Dec 2017

Zinc present in semen determines male fertility, study shows

Trace levels of zinc present in semen is a vital determinant of male fertility, a recent study in Bangladesh capital Dhaka concludes.

19 Dec 2017

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Rejected antibiotic candidate could be worth a second look, research finds

An antibiotic candidate compound shelved in the 1970s in favour of more worthwhile drugs could be worth a second look, new research has found.

15 Dec 2017

Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Predicting how patients will respond to anti-cancer therapies can be vital in informing clinical decisions and improving treatment outcome.

15 Dec 2017

Human ‘common cold’ virus kills healthy chimpanzees in Uganda

In the wild, chimpanzees face any number of dire threats, ranging from poachers to predators to deforestation.

13 Dec 2017

Protein structure could pave way for effective drugs to treat cystic fibrosis

Biochemists at the University of Zurich have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to treat cystic fibrosis.

13 Dec 2017

Researchers uncover novel strategy to program immune system for fighting cancer

Looking to bolster the body's immune system in the fight against infection and cancer, researchers at the University of California San Diego and their colleagues have identified a promising new strategy to program the immune system to meet the pathogen or malignancy in the tissues where they first pose a threat.

11 Dec 2017

Study provides new insights into mechanism of tumor survival in glioblastoma

A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation therapy.

11 Dec 2017

Russian researchers create new approaches to prevention and treatment of diabetes

A team of scientists from the Ural Federal University and the Institute of Immunology and Physiology modeled type 1 diabetes in an experiment to study recovery processes in the pancreas.

11 Dec 2017

Researchers seek to understand role of novel protein in tumor metastasis

Metastasis, the process in which a tumor spreads to other parts of the body, is responsible for 90% of deaths from tumors. It is the greatest challenge to a cancer patient's survival. Metastatic spread occurs in several steps, these include that tumor cells become mobile and cross into and out of blood vessels.

8 Dec 2017

UT Southwestern researchers identify potential approach to suppress lethal parasitic infections

UT Southwestern Medical Center researchers have identified a chemical that suppresses the lethal form of a parasitic infection caused by roundworms that affects up to 100 million people and usually causes only mild symptoms.

5 Dec 2017

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

New biomarker test can accurately predict which chemical compounds induce DNA damage

A new biomarker test developed by researchers at Georgetown Lombardi Comprehensive Cancer Center and their colleagues can help predict, with up to 90 percent certainty, which chemical compounds can cause DNA damage that could lead to cancer.

5 Dec 2017

UC San Diego researchers receive nearly $8 million grant for new stem cell-based AML treatments

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.

4 Dec 2017

Study identifies new role for stress receptor CRF1 expressed on mast cells

A new study published online in the Journal of Leukocyte Biology provides new insight into how stress, through signaling of corticotropin-releasing factor (CRF), interacts with cells in the immune system to cause disease.

1 Dec 2017

Laser techniques could help revolutionize understanding of neurodegenerative diseases

Boulder researchers are embarking on a new project to study the progression of neurodegenerative diseases like Alzheimer's by using a new technique to measure neurons firing deep inside animal brains.

1 Dec 2017

Biochemistry News and Research

Unique mechanism of drug resistance found in pandemic cholera

Novel drug shows promise in treating metastatic kidney cancer

FDA-approved drug to treat high blood pressure increases life span in worms

Epigenetics: A New Tool for Forensic Detectives

Zinc present in semen determines male fertility, study shows

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Rejected antibiotic candidate could be worth a second look, research finds

Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Human ‘common cold’ virus kills healthy chimpanzees in Uganda

Protein structure could pave way for effective drugs to treat cystic fibrosis

Researchers uncover novel strategy to program immune system for fighting cancer

Study provides new insights into mechanism of tumor survival in glioblastoma

Russian researchers create new approaches to prevention and treatment of diabetes

Researchers seek to understand role of novel protein in tumor metastasis

UT Southwestern researchers identify potential approach to suppress lethal parasitic infections

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

New biomarker test can accurately predict which chemical compounds induce DNA damage

UC San Diego researchers receive nearly $8 million grant for new stem cell-based AML treatments

Study identifies new role for stress receptor CRF1 expressed on mast cells

Laser techniques could help revolutionize understanding of neurodegenerative diseases

Understanding the DNA Damage Response in Innate Immunity eBook

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