Cell Death News and Research

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Bioactive compound from neem plant shows promising effects on prostate cancer

A team of international researchers led by Associate Professor Gautam Sethi from the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore has found that nimbolide, a bioactive terpenoid compound derived from Azadirachta indica or more commonly known as the neem plant, could reduce the size of prostate tumour by up to 70 per cent and suppress its spread or metastasis by half.

29 Sep 2016

Researchers reveal how ultrasmall nanoparticles can kill cancer cells

Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.

29 Sep 2016

Tau PET imaging in Alzheimer's disease increases opportunities for developing effective drugs

Tau PET is a new and promising imaging method for Alzheimer's disease. A case study from Lund University in Sweden now confirms that tau PET images correspond to a higher degree to actual changes in the brain. According to the researchers behind the study, this increases opportunities for developing effective drugs.

28 Sep 2016

Scientists discover new switch that coordinates DNA repair and cell death

The genetic information of every cell is encoded in the sequence of the DNA double helix. Double strand breaks in the DNA, which can be induced by radiation, are a dangerous threat to the cells, and if not properly repaired can lead to cancer.

28 Sep 2016

Approval of PD-1 inhibitor scratches surface of potential immunotherapies in recurrent HNSCC

The recent approval of pembrolizumab (Keytruda) in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) following progression on a platinum-based chemotherapy was a significant advancement for the disease.

26 Sep 2016

KAUST researchers develop biocompatible nanostructures for use in gene delivery

A tiny therapeutic delivery system that can control the body’s ability to manufacture proteins has been developed by Saudi Arabia's King Abdullah University of Science and Technology (KAUST) researchers.

24 Sep 2016

Tumour suppressor gene has greater anti-cancer activity than previously thought

New insight into the function of a gene important in the suppression of cancer is published today. Researchers at the National University of Ireland Galway have shown that the TP53 gene has even greater anti-cancer activity than previously thought.

22 Sep 2016

Research re-opens door to possibility of stopping ongoing brain damage

A breakthrough in understanding how brain damage spreads - and how it could potentially be limited - has been made through a collaboration between neuroscientists and engineers at the Universities of Dundee and Strathclyde.

21 Sep 2016

BET inhibitors could be powerful new therapeutic strategy for ovarian cancer

Few effective treatments have been approved to treat ovarian cancer, the deadliest of all cancers affecting the female reproductive system.

14 Sep 2016

New study identifies potential therapeutic option for treatment of Huntington's disease

A new scientific study reveals one way to stop proteins from triggering an energy failure inside nerve cells during Huntington's disease. Huntington's disease is an inherited genetic disorder caused by mutations in the gene that encodes huntingtin protein.

14 Sep 2016

ATR inhibitors show improved survival and effectiveness in animal models of cancer

Tumours are an accumulation of cells that divide without control, accumulating hundreds of chromosomal alterations and mutations in their DNA.

13 Sep 2016

Researchers identify genes that regulate cellular senescence

A research group including Professor KAMADA Shinji, Research Fellow NAGANO Taiki (both from the Kobe University Biosignal Research Center), and Unit Chief ENARI Masato (National Cancer Research Institute) has succeeded in identifying genes that control cellular senescence - permanently arrested cell growth.

13 Sep 2016

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

Cell Death News and Research

Bioactive compound from neem plant shows promising effects on prostate cancer

Researchers reveal how ultrasmall nanoparticles can kill cancer cells

Tau PET imaging in Alzheimer's disease increases opportunities for developing effective drugs

Scientists discover new switch that coordinates DNA repair and cell death

Approval of PD-1 inhibitor scratches surface of potential immunotherapies in recurrent HNSCC

KAUST researchers develop biocompatible nanostructures for use in gene delivery

Tumour suppressor gene has greater anti-cancer activity than previously thought

Research re-opens door to possibility of stopping ongoing brain damage

BET inhibitors could be powerful new therapeutic strategy for ovarian cancer

New study identifies potential therapeutic option for treatment of Huntington's disease

ATR inhibitors show improved survival and effectiveness in animal models of cancer

Researchers identify genes that regulate cellular senescence

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Clinical trial to examine effectiveness of diabetes drug to slow or stop progression of Parkinson's

Researchers reveal how traditional Chinese medicine helps treat various cancers

Scientists developing virtual reality-based early diagnosis system for neurodegenerative disorders

Researchers uncover molecular differences between African and Asian strain of Zika virus infections

Nanopores can be effective way to measure DNA interactions with emerging anti-cancer drugs

Research findings of protein may form foundation for new approach to antibiotics

Moderation and appropriate rest periods may be key to healthier CrossFit workouts

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