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UTSA chemistry professor awarded NSF grant to advance research on the body's metabolic processes

Chemistry professor Aimin Liu has been awarded a three-year, $495,000 Accomplishment-Based Renewal (ABR) grant from the National Science Foundation (NSF) to advance his research on the body's metabolic processes using an innovative method that will improve the understanding of amino acids.

1 Jul 2022

Researchers uncover a novel interplay between coral pathogen and other coral commensal bacteria

Coral is a complicated holobiont, harboring an array of life forms at different scales, including coral cells, zooxanthellae, and associated bacteria, archaea, and viruses.

1 Jul 2022

Machine-learning algorithms can help distinguish acute cholangitis and alcohol-associated hepatitis

Acute cholangitis is a potentially life-threatening bacterial infection that often is associated with gallstones. Symptoms include fever, jaundice, right upper quadrant pain, and elevated liver enzymes.

1 Jul 2022

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

Researchers explored the molecular basis for increased immunity against heterologous SARS-CoV-2 strains after repeated antigen exposures.

1 Jul 2022

The antiviral effects of thiol drugs in COVID-19

A recent study investigated the effects of thiol drugs on SARS-CoV-2.

1 Jul 2022

The impact of pre-existing immunity on mRNA booster doses of BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2

Researchers assessed the impact of pre-existing immunity on mRNA booster doses of BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2.

1 Jul 2022

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

Researchers developed a new detection assay for SARS-CoV-2.

1 Jul 2022

Stopping a pervasive bacterium that makes millions sick each year

As we head outdoors this summer, scientists are working to clip the long, flexible appendages that enable the common bacterium Campylobacter jejuni to make its way from undercooked poultry and natural waterways into our intestinal tract where it makes millions of us sick each year.

1 Jul 2022

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

In a recent article posted to the bioRxiv* preprint server, researchers at Rutgers, the State University of New Jersey, the University of South Florida, and the Catholic University of America demonstrated that the natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) mutations result in nirmatrelvir resistance.

30 Jun 2022

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

A recent study posted to the bioRxiv* preprint server supports using mosaic sarbecovirus receptor-binding domain (RBD)-nanoparticles to discover therapeutic pan-variant and pan-sarbecovirus monoclonal antibodies (mAbs) and to induce mAbs by vaccination.

30 Jun 2022

Age-specific susceptibility during the Omicron driven, Delta driven, and pre-Delta waves in South Korea

Researchers assessed the relative age-varying susceptibility to SARS-CoV-2 Omicron strain infections compared to the SARS-CoV-2 Delta strain and pre-Delta strains in South Korea.

30 Jun 2022

The effects and mechanisms of SARS-CoV-2 on the nervous system

Researchers reviewed the neurologic manifestations associated with SARS-CoV-2.

30 Jun 2022

Identification of potent SARS-CoV-2 macrodomain inhibitors

A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) inhibitor based on structure.

30 Jun 2022

SARS-CoV-2 3CLpro also susceptible to mutations

Researchers assess the activity of all potential mutations in the SARS-CoV-2 3CLpro.

29 Jun 2022

Discovery suggests a new way to slow or stop metastatic spread of pancreatic cancer

Pancreatic cancer, though rare, is one of the deadliest of cancers, killing nearly 50,000 people yearly and doing so quickly, primarily because it metastasizes rapidly through the body. Barely one in 10 people survive beyond five years.

29 Jun 2022

Anticancer drug candidate that targets a human protein could be a pan-viral medication

More than two years into the COVID-19 pandemic, people are realizing that the "new normal" will probably involve learning to co-exist with SARS-CoV-2. Some treatments are available, but with new variants emerging, researchers are looking toward new strategies.

29 Jun 2022

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Researchers assessed the impact of SARS-CoV-2 envelope protein on the bromodomain and extraterminal domain (BET) proteins.

29 Jun 2022

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Like many neurological diseases, there's a lot we don't understand about fragile X syndrome. But, after studying the disorder for several years, Lynne Maquat's lab knew two important things: the enzyme AKT, which plays a key role in cell growth and survival, and the quality control pathway known as NMD (nonsense-mediated mRNA decay), are both in overdrive in fragile X.

29 Jun 2022

Study focuses on how telomerase activity affects the regenerative potential of stem cells in human urine

The Wake Forest Institute for Regenerative Medicine researchers who were the first to identify that stem cells in human urine have potential for tissue regenerative effects, continue their investigation into the power of these cells.

28 Jun 2022

New study looks at the role of beta cells in triggering autoimmunity

Research into the causes of type 1 diabetes often focuses on the autoimmune response, where the immune system destroys pancreatic islet beta cells that produce insulin.

28 Jun 2022

Enzyme News and Research

UTSA chemistry professor awarded NSF grant to advance research on the body's metabolic processes

Researchers uncover a novel interplay between coral pathogen and other coral commensal bacteria

Machine-learning algorithms can help distinguish acute cholangitis and alcohol-associated hepatitis

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

The antiviral effects of thiol drugs in COVID-19

The impact of pre-existing immunity on mRNA booster doses of BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

Stopping a pervasive bacterium that makes millions sick each year

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

Age-specific susceptibility during the Omicron driven, Delta driven, and pre-Delta waves in South Korea

The effects and mechanisms of SARS-CoV-2 on the nervous system

Identification of potent SARS-CoV-2 macrodomain inhibitors

SARS-CoV-2 3CLpro also susceptible to mutations

Discovery suggests a new way to slow or stop metastatic spread of pancreatic cancer

Anticancer drug candidate that targets a human protein could be a pan-viral medication

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Study focuses on how telomerase activity affects the regenerative potential of stem cells in human urine

New study looks at the role of beta cells in triggering autoimmunity

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