Preclinical News and Research

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Comprehensive review: Nanomaterial-based delivery vehicles for cancer vaccine development

Over the years, significant advancements in cancer research have led us to the next step in cancer therapy – vaccines for cancer! However, the direct use of these vaccines in the affected individuals have often failed to bring about desired anti-tumor effects.

3 Aug 2021

Lipid blast shield protects natural killer cells and also some cancer cells

A newly discovered fat 'shield' that prevents natural killer cells from being destroyed by their own deadly biological weapons also allows some cancer cells to evade an immune system attack, a study at Columbia University has found.

3 Aug 2021

SARS-CoV-2 Delta and Delta AY.1 variant show similar Covaxin-induced neutralization

A new study from India suggests that the Indian-made Covaxin whole-virus inactivated vaccine against the SARS-CoV-2 retains significant efficacy against the newer delta variants of the virus.

3 Aug 2021

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

A new strategy for developing vaccines against cancer showed promise in a proof-of-concept study led by scientists at Weill Cornell Medicine, NewYork-Presbyterian and Heidelberg University Hospital.

2 Aug 2021

Customized, biomedically applicable materials based on tropoelastin for wound care

Customized, biomedically applicable materials based on tropoelastin are being developed in a joint project by Skinomics GmbH from Halle, Martin Luther University Halle-Wittenberg and the Fraunhofer Institute for Microstructure of Materials and Systems IMWS.

2 Aug 2021

Physical pain induces relapse of alcohol consumption, research shows

The study has also shown changes in an area of the brain related to motivation for drug intake, and in a second experiment they have shown that the kappa-type opioid receptor (a protein) is key to causing these animals to relapse.

27 Jul 2021

Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy

Researchers from the Institute of Process Engineering of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy.

26 Jul 2021

Air quality improvement linked with reduced risk of dementia

Improving air quality may improve cognitive function and reduce dementia risk, according to several studies reported today at the Alzheimer's Association International Conference 2021 in Denver and virtually.

26 Jul 2021

More popular type of antihypertensive drugs causes slightly more side effects

Two types of drugs that are recommended as a first treatment for patients with high blood pressure were found equally effective in improving cardiovascular outcomes, but the more popular type causes slightly more side effects, finds a multinational observational study led by researchers at Columbia University Vagelos College of Physicians and Surgeons.

26 Jul 2021

Study shows promise of combining radiation therapy with dendritic-cell vaccines for breast cancer

A research team led by Fumito Ito, MD, PhD, FACS, of Roswell Park Comprehensive Cancer Center reports new data on the promise of combining standard treatment for breast cancer with a particular form of cancer immmunotherapy - dendritic-cell (DC) treatment vaccines.

20 Jul 2021

Next-generation COVID-19 vaccine provides robust immunity against SARS-CoV-2 in mice

Researchers in Canada have developed an adenoviral vector-based vaccine against coronavirus disease 2019 (COVID-19) that induced robust immune protection against the ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.

20 Jul 2021

Redhill Biopharma announces completion of Phase 2/3 COVID-19 study of oral opaganib

RedHill Biopharma Ltd., a specialty pharma company that is a leader in the development of novel oral therapies for COVID-19, today announced that all treatment and follow-up has now been completed in the 475-patient global Phase 2/3 study with opaganib (ABC294640) in patients hospitalized with severe COVID-19 pneumonia (NCT04467840). Top-line results are expected in the coming weeks.

20 Jul 2021

Chemical modification in RNA molecules may offer protection against liver disease

A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells' protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver and can lead to advanced liver disease, according to a new study by UCLA researchers.

19 Jul 2021

Researchers use appendiceal cancer organoids to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

19 Jul 2021

New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer's, Parkinson's, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies.

19 Jul 2021

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

A new study published in Vaccine assesses the safety and efficacy of the synthetic DNA vaccine candidate INO-4800, delivered as a single or double dose regime.

18 Jul 2021

'Super glue' from snake venom can stop life-threatening bleeding in seconds

Indiana Jones hates snakes. And he's certainly not alone. The fear of snakes is so common it even has its own name: ophidiophobia.

15 Jul 2021

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Researchers in the United States have designed a modular protein subunit vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited a strong immune response in macaques and prevented the animals from developing coronavirus disease 2019 (COVID-19).

15 Jul 2021

Autophagy disruption may be at the root of early cognitive changes in Huntington’s disease

Huntington's Disease (HD) is a progressive neurodegenerative condition characterized by motor, cognitive, and psychiatric symptoms, and motor symptoms are often preceded by cognitive changes.

15 Jul 2021

Heart problems in kids with MIS-C resolve rapidly, study shows

Heart problems in children hospitalized with multisystem inflammatory syndrome (MIS-C)--an inflammatory condition triggered by COVID--were mostly gone within a few months, a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found.

15 Jul 2021

Preclinical News and Research

Comprehensive review: Nanomaterial-based delivery vehicles for cancer vaccine development

Lipid blast shield protects natural killer cells and also some cancer cells

SARS-CoV-2 Delta and Delta AY.1 variant show similar Covaxin-induced neutralization

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

Customized, biomedically applicable materials based on tropoelastin for wound care

Physical pain induces relapse of alcohol consumption, research shows

Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy

Air quality improvement linked with reduced risk of dementia

More popular type of antihypertensive drugs causes slightly more side effects

Study shows promise of combining radiation therapy with dendritic-cell vaccines for breast cancer

Next-generation COVID-19 vaccine provides robust immunity against SARS-CoV-2 in mice

Redhill Biopharma announces completion of Phase 2/3 COVID-19 study of oral opaganib

Chemical modification in RNA molecules may offer protection against liver disease

Researchers use appendiceal cancer organoids to study personalized immunotherapy response

New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

'Super glue' from snake venom can stop life-threatening bleeding in seconds

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Autophagy disruption may be at the root of early cognitive changes in Huntington’s disease

Heart problems in kids with MIS-C resolve rapidly, study shows

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Advancing degrader and proximity-based drug development

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics