Proliferation News and Research

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Novartis, Bristol-Myers Squibb collaborate to examine combination therapies for metastatic colorectal cancer

Novartis today announced it has entered into a clinical research collaboration in which Bristol-Myers Squibb will investigate the safety, tolerability, and efficacy of Mekinist (trametinib) in combination with Opdivo (nivolumab) and Opdivo + Yervoy (ipilimumab) regimen as a potential treatment option for metastatic colorectal cancer in patients with microsatellite stable tumors where the tumors are proficient in mismatch repair (MSS mCRC pMMR).

5 Jun 2017

Tumorigenesis may be induced from neighboring tissues, study suggests

Current view is that cancer development is initiated from cells that acquire initial DNA mutations. These in turn provoke additional defects, and ultimately the affected cells begin to proliferate in an uncontrolled manner to develop primary tumors.

2 Jun 2017

Cancer treatment may be effective therapy for psoriasis

HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report.

31 May 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

California’s new single-payer proposal embraces some costly old ways

Three of the dirtiest words in health care are "fee for service." For years, U.S. officials have sought to move Medicare away from paying doctors and hospitals for each task they perform, a costly approach that rewards the quantity of care over quality. State Medicaid programs and private insurers are pursuing similar changes.

31 May 2017

Study finds that immune factors have cardioproliferative effects

In adult mammal hearts, cardiomyoctyes do not proliferate following damage, like that caused by myocardial infarction. However, the inability to proliferate is not true for all animals, and even in mammals, cardiomyocyte proliferation is known.

30 May 2017

UNC researchers discover cascade of gene activity during journey to maturation in fruit flies

Every animal starts as a clump of cells, which over time multiply and mature into many different types of cells, tissues, and organs.

26 May 2017

Molecule discovered in worm spit could offer solution for non-healing wounds

Every day 12 Australian diabetics have a limb amputated because of a non-healing wound. Globally, it's one every 30 seconds.

25 May 2017

Scientists unravel mystery of T cell signaling process vital to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained a mystery.

16 May 2017

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

A study published now on Nature Communications shows that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive.

16 May 2017

Discovery of steroid hormone in fruit flies may shed new light on maternal hypothyroidism

University of Oregon researchers using Drosophila have identified a steroid hormone that triggers a vital transition in early brain development in which neural stem cells properly change gears to produce different kinds of neurons.

15 May 2017

LMU scientists uncover molecular mechanism that links tumor hypoxia and metastasis

The low oxygen concentrations that prevail in many tumors enhance their propensity to metastasize to other tissues. Researchers at Ludwig-Maximilians-Universitaet in Munich led by Professor Heiko Hermeking have now uncovered the molecular mechanism that links the two phenomena.

11 May 2017

UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models

Researchers at the University of Cincinnati have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.

10 May 2017

Scientists study cell’s reaction to Salmonella by visualizing protein chains at near-molecular level

With drug resistance being on the rise worldwide, bacterial infections pose one of the greatest global threats to human health. By deciphering the host-pathogen interaction on a molecular level, researchers hope to pave the way for new therapies.

10 May 2017

Testosterone protects males against developing asthma, research reveals

An international research team has revealed for the first time that testosterone protects males against developing asthma, helping to explain why females are two times more likely to develop asthma than males after puberty.

8 May 2017

Study: Use of white blood cell boosting drugs found to be safe during chemo-radiotherapy of lung cancer

A late breaking subanalysis of the phase III CONVERT trial presented at the European Lung Cancer Conference shows that white blood cell boosting drugs are safe during concurrent chemo-radiotherapy of small cell lung cancer (SCLC).

5 May 2017

TSRI scientists uncover regulatory machinery underlying the function of cancer protein

Despite intense research, there's been much confusion regarding the exact role of a protein in a critical cancer-linked pathway. On one hand, the protein is described as a cell proliferation inhibitor, on the other, a cell proliferation activator, a duality that has caused a great deal of scientific head scratching.

5 May 2017

Lethal DNA re-replication may be used to attack cancer cells

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, composition and/or number of chromosomes), and this process gives rise to aberrant cells as those detected in many carcinomas.

4 May 2017

Impaired effects of insulin can increase cancer risk, shows study

Over the decades, scientists have repeatedly shown that patients with increased levels of the hormone insulin in their blood can experience increased risks of cancer. Surprisingly, however, Joslin Diabetes Center researchers now have discovered that impaired effects of insulin also can boost these risks.

3 May 2017

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Surgery and radiation remove, kill, or damage cancer cells in a certain area. But chemotherapy -- which uses medicines or drugs to treat cancer -- can work throughout the whole body, killing cancer cells that have spread far from the original tumor.

2 May 2017

Proliferation News and Research

Novartis, Bristol-Myers Squibb collaborate to examine combination therapies for metastatic colorectal cancer

Tumorigenesis may be induced from neighboring tissues, study suggests

Cancer treatment may be effective therapy for psoriasis

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

California’s new single-payer proposal embraces some costly old ways

Study finds that immune factors have cardioproliferative effects

UNC researchers discover cascade of gene activity during journey to maturation in fruit flies

Molecule discovered in worm spit could offer solution for non-healing wounds

Scientists unravel mystery of T cell signaling process vital to immune response

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

Discovery of steroid hormone in fruit flies may shed new light on maternal hypothyroidism

LMU scientists uncover molecular mechanism that links tumor hypoxia and metastasis

UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models

Scientists study cell’s reaction to Salmonella by visualizing protein chains at near-molecular level

Testosterone protects males against developing asthma, research reveals

Study: Use of white blood cell boosting drugs found to be safe during chemo-radiotherapy of lung cancer

TSRI scientists uncover regulatory machinery underlying the function of cancer protein

Lethal DNA re-replication may be used to attack cancer cells

Impaired effects of insulin can increase cancer risk, shows study

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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