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Study confirms poor immunogenicity in hemodialysis patients receiving single dose BNT162b2 vaccine

Researchers from Ontario, Canada, recently conducted a prospective observational study to determine the SARS-CoV-2 antibody response in chronic hemodialysis patients following one vs. two doses of the BNT162b2 COVID-19 vaccine. The results were compared to health care worker controls and convalescent serum.

1 Jun 2021

Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO

Moffitt Cancer Center, a national leader in cancer care and research and the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, is presenting new data from dozens of clinical research studies at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, the world's largest clinical cancer research meeting.

1 Jun 2021

Function and regeneration of dendritic cells impaired in COVID-19

A group of researchers from Germany has investigated and analyzed circulating dendritic cells and monocyte subsets in 65 hospitalized COVID-19 patients with mild to severe presentations of the infection. A variety of patients were included in their study, from those who exhibited minor signs of acute disease to convalescents, as well as healthy controls

31 May 2021

A novel multiplexed diagnostic approach for COVID-19

Researchers developed a platform for detecting the virus directly from a patient's sample as well as the immune response through antibodies such as IgG and IgM.

31 May 2021

SARS-CoV-2 variants partially escape humoral immunity, but not T cells responses, study finds

Researchers at the Department of Viroscience, Erasmus MC, National Institute for Public Health and the Environment, Amsterdam UMC, and the Weill Medical College of Cornell University studied humoral and cellular immune responses to the wild type SARS-CoV-2, the B.1.1.7 variant (U.K. variant) and the B.1.351 variant (South African variant) in health care workers vaccinated with the BNT162b2 (Pfizer-BioNTech) mRNA vaccine.

31 May 2021

Different early antibody responses define COVID-19 disease trajectory

In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease trajectory two days after a positive test.

31 May 2021

India is banking on locally developed kit to increase COVID-19 testing

India is banking on a locally developed, affordable home-use kit to bump up testing for COVID-19 and reduce the burden on public resources struggling against a runaway pandemic now raging through the country in a deadly second wave.

31 May 2021

Composition and function of gut microbiota are key in affecting immune responses to vaccinations

Varying immune response to vaccinations could be countered with microbiota-targeted interventions helping infants, older people and others to take full advantage of the benefits of effective vaccines, Australian and US experts say.

29 May 2021

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

A new study, published in Nano Letters, describes an effective new COVID-19 vaccine candidate based on a messenger ribonucleic acid (mRNA) platform.

28 May 2021

Loss of gut epithelial barrier responsible for COVID-19-related MIS-C in children, suggests study

A new paper in the Journal of Clinical Investigation reports that this condition is due to damage to the gut, mediated by a decrease in the protein called zonulin, which is responsible for the integrity of the gut epithelial barrier. Reduced zonulin levels are found in several inflammatory and autoimmune conditions.

28 May 2021

Will emerging SARS-CoV-2 variants affect T cell immunity? A meta-analysis

New research by a team of scientists at The Hong Kong University of Science and Technology sheds light on the epitopic targets of SARS-CoV-2 by T cells in COVID-19 convalescents. The team’s findings suggest that the epitopes targeted by T cells during infection may not be affected by the emergence of SARS-CoV-2 variants.

28 May 2021

Pfizer-BioNTech COVID-19 vaccine may not be associated with adverse effects on fertility and breastfeeding, says study

A recent study by researchers in Singapore shows the absence of evidence for adverse effects on fertility or the presence of the vaccine mRNA (messenger ribonucleic acid) in breast milk, following the administration of the Pfizer BNT162B2 COVID-19 vaccine. This supports efforts to prevent the spread of false information about the effects of the vaccine.

27 May 2021

Study shows CoronaVac to have high seroconversion rate after 40 days

Researchers from the Federal University of Paraná, Brazil, looked into the seroconversion rate after vaccination with the CoronaVac. Using immunoassays, they measured the immunoglobulins (IgG) for anti-nucleocapsid protein (anti-N) antibodies and anti-spike-1 (anti-S1) protein antibodies.

27 May 2021

Disproportionate number of SARS-CoV-2 breakthrough infections are caused by variants of concern

A study conducted by researchers in the United States has shown that among twenty patients with breakthrough infection following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – all of the infections were caused by variants of concerns.

26 May 2021

Intensity and duration of SARS-CoV-2 immunity may depend on ABO blood group

A team of scientists from Canada and Spain recently evaluated the durability of antigen-specific immune responses in COVID-19 recovered individuals. They have also identified potential host factors associated with robust and long-lasting anti-SARS-CoV-2 immunity.

26 May 2021

Could GRP78 be a therapeutic target against COVID-19?

A new study by a team of researchers at the Keck School of Medicine, University of Southern California, USA, reports a potentially important therapeutic target in the form of a molecule called GRP78 that promotes the entry and protein production by many viruses. The team's paper has been published in the Journal of Biological Chemistry.

26 May 2021

Tissue-resident memory T cells found in lungs of people who had COVID-19 10 months ago

In recent research by Judith Grau-Expósito et al., scientists identify circulating virus-specific T cell responses during acute SARS-CoV-2 infection with functional, migratory, and apoptotic patterns modulated by viral proteins and associated with clinical outcome.

26 May 2021

An exploratory study of T-cell and antibody responses after COVID-19 mRNA vaccination

Recent COVID-19 investigations have found that up to half of immunocompromised individuals struggle to produce antibodies after receiving their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations.

26 May 2021

Previous H3N2 influenza A infection may explain some cases of severe COVID-19

According to research from the University of California, some cases of severe coronavirus disease 2019 (COVID-19) may be related to the immunological memory of previous H3N2 influenza A infection.

26 May 2021

Study shows how rare but serious post-COVID-19 complication develops in children, adolescents

A multidisciplinary team from MassGeneral Hospital for Children (MGHfC), Brigham and Women's Hospital and other institutions have identified the mechanism of how an extremely rare but serious post-COVID-19 complication develops in children and adolescents.

26 May 2021

Antigen News and Research

Study confirms poor immunogenicity in hemodialysis patients receiving single dose BNT162b2 vaccine

Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO

Function and regeneration of dendritic cells impaired in COVID-19

A novel multiplexed diagnostic approach for COVID-19

SARS-CoV-2 variants partially escape humoral immunity, but not T cells responses, study finds

Different early antibody responses define COVID-19 disease trajectory

India is banking on locally developed kit to increase COVID-19 testing

Composition and function of gut microbiota are key in affecting immune responses to vaccinations

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

Loss of gut epithelial barrier responsible for COVID-19-related MIS-C in children, suggests study

Will emerging SARS-CoV-2 variants affect T cell immunity? A meta-analysis

Pfizer-BioNTech COVID-19 vaccine may not be associated with adverse effects on fertility and breastfeeding, says study

Study shows CoronaVac to have high seroconversion rate after 40 days

Disproportionate number of SARS-CoV-2 breakthrough infections are caused by variants of concern

Intensity and duration of SARS-CoV-2 immunity may depend on ABO blood group

Could GRP78 be a therapeutic target against COVID-19?

Tissue-resident memory T cells found in lungs of people who had COVID-19 10 months ago

An exploratory study of T-cell and antibody responses after COVID-19 mRNA vaccination

Previous H3N2 influenza A infection may explain some cases of severe COVID-19

Study shows how rare but serious post-COVID-19 complication develops in children, adolescents

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