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Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs).

28 Jun 2022

Acute illness increases cortisol levels in children and adolescents

A new study reports that in children and adolescents without glucocorticoid deficiency, circulating cortisol levels were higher during acute illnesses.

28 Jun 2022

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

Scientists from China have recently deciphered the genetic network and biological mechanisms associated with COVID-19 myocarditis using bioinformatic methods.

28 Jun 2022

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a center jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya.

28 Jun 2022

New technique offers higher-precision scRNA-seq data than current technologies

The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized the fields of medicine and biology by providing the ability to study the inner workings of thousands of cells at one go.

28 Jun 2022

Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

Researchers performed genomic comparisons between alphacoronaviruses (αCoVs) and betacoronaviruses (βCoVs) originating from South Korean Bats.

28 Jun 2022

The potential of DNA-based SARS-CoV-2 vaccine candidates

Researchers evaluated the immunogenicity of DNA-based candidate vaccines against SARS-CoV-2 in mice.

28 Jun 2022

Cell-based assay highlights differences in antibody neutralizing capacity for SARS-CoV-2 variants

A recent study by scientists at Celentyx Ltd, the University of Birmingham, and the University of Warwick and posted to the bioRxiv* preprint server illustrated a cell-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein attachment assay.

28 Jun 2022

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

In a recent article posted to the bioRxiv* preprint server, researchers at Texas Biomedical Research Institute, Georgia State University, and the University of Alabama at Birmingham developed a bireporter-expressing recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) for tracking SARS-CoV-2 infection.

27 Jun 2022

Researchers discover a molecular switch that promotes pancreatic cancer metastasis

More than 62,000 people in the United States will be diagnosed with pancreatic cancer by the end of this year, with the vast majority having a deadly and aggressive subtype known as pancreatic ductal adenocarcinoma (PDA).

27 Jun 2022

Restricting timing of high fat intake improves markers of kidney and vascular health in mice

New research in a mouse model of diet-induced obesity finds that time-restricted feeding improves markers of kidney and vascular health.

27 Jun 2022

Omicron variant of SARS-CoV-2 leads to less severe disease in mouse models

Georgia State University researchers have found that the Alpha, Beta and Delta variants of SARS-CoV-2 were substantially more fatal in mouse models than the original strain of the virus that causes COVID-19.

27 Jun 2022

Study discovers microbial link between Western-style diet and colorectal cancer risk

New research builds the case that a Western-style diet - rich in red and processed meat, sugar and refined grains/carbohydrates - is tied to higher risk of colorectal cancer through the intestinal microbiota. Investigators from Brigham and Women's Hospital with collaborators looked at data from more than 134,000 participants from two U.S.-wide prospective cohort studies.

27 Jun 2022

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters

Scientists conducted a meta-analysis to study the impacts of COVID-19 on the male reproductive system.

27 Jun 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

The prevalence of long-COVID in children and adolescents

A recent study published in the Scientific Reports journal assessed the incidence of long-coronavirus disease (COVID) among adolescents and children.

27 Jun 2022

CHMP recommends approval of upadacitinib (RINVOQ®) for the treatment of adults with active non-radiographic axial spondyloarthritis

AbbVie today announced the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) recommended the approval of upadacitinib (RINVOQ® 15 mg, once daily) for the treatment of active non-radiographic axial spondyloarthritis (nr‑axSpA) in adult patients with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI), who have responded inadequately to nonsteroidal anti-inflammatory drugs (NSAIDs).*

27 Jun 2022

Researchers identify orally efficacious antiviral drug against respiratory syncytial virus

An oral antiviral drug that targets a key part of the respiratory syncytial virus (RSV) polymerase and inhibits the synthesis of viral genetic material has been identified, a finding that could provide an effective treatment against RSV disease, according to researchers in the Center for Translational Antiviral Research at Georgia State University.

24 Jun 2022

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Scientists have described the development of a modified A549 cell line that shows a robust expression of ACE2 and TMPRSS2 and high susceptibility to SARS-CoV-2 infection.

24 Jun 2022

Mild COVID causes increase in neurotoxic metabolites

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the blood levels of neurotoxic metabolites in patients with mild coronavirus disease 2019 (COVID-19).

23 Jun 2022

Enzyme News and Research

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

Acute illness increases cortisol levels in children and adolescents

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

New technique offers higher-precision scRNA-seq data than current technologies

Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

The potential of DNA-based SARS-CoV-2 vaccine candidates

Cell-based assay highlights differences in antibody neutralizing capacity for SARS-CoV-2 variants

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

Researchers discover a molecular switch that promotes pancreatic cancer metastasis

Restricting timing of high fat intake improves markers of kidney and vascular health in mice

Omicron variant of SARS-CoV-2 leads to less severe disease in mouse models

Study discovers microbial link between Western-style diet and colorectal cancer risk

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

The prevalence of long-COVID in children and adolescents

CHMP recommends approval of upadacitinib (RINVOQ®) for the treatment of adults with active non-radiographic axial spondyloarthritis

Researchers identify orally efficacious antiviral drug against respiratory syncytial virus

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Mild COVID causes increase in neurotoxic metabolites

Understanding the DNA Damage Response in Innate Immunity eBook

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