Mouse Model News and Research

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Scientists develop universal vaccine with the potential to protect against multiple flu strains

Researchers have developed a universal vaccine that can protect against multiple strains of influenza in animals.

22 Aug 2018

Discovery could lead to new targeted treatment for people with lung cancer

Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications.

22 Aug 2018

Study compares T-cell signaling patterns in two different CAR designs

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined.

21 Aug 2018

A form of vitamin B3 shows potential to prevent acute kidney injury

Acute kidney injury, an often fatal condition without a specific treatment, affects up to 10 percent of all hospitalized adults in the United States and 30-40 percent in low-income countries.

21 Aug 2018

Thrombospondin-1 contributes to development of aortic aneurysm in mice and humans, study finds

Researchers centered at the University of Tsukuba and Kansai Medical University in Japan reveal matricellular protein Thrombospondin-1 (Thbs1) contributes to the development of aortic aneurysm in mice and humans.

20 Aug 2018

Understanding How Antibodies Shape the Gut Microbiome

Dr. Keiichiro Suzuki discusses the importance of IgA in the human body, and his recent research study, which showed that IgA interacts with the gut microbiome and promotes the growth of healthy bacteria.

20 Aug 2018

Brief exposures to stressors can be beneficial to cells, shows study

We've all heard the expression: "what doesn't kill you makes you stronger." Now, research led by a Salk Institute scientist suggests why, at a cellular level, this might be true.

17 Aug 2018

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the ability to observe and understand the disease.

16 Aug 2018

Ablating the mutant p53 gene in mice with colorectal cancer inhibits tumor growth

By genetically manipulating and removing the most common mutant form of the p53 gene that promotes colorectal cancer in humans, an international team of scientists demonstrated that this therapy reduces tumor growth and tissue invasion.

15 Aug 2018

Scientists reverse congenital blindness in mouse model

A study funded by the National Eye Institute has shown that congenital blindness in mice can be reversed by regenerating rod photoreceptors in the retina.

15 Aug 2018

Cruciferous vegetables found to protect against colon cancer in mice

Researchers have revealed how vegetables such as broccoli, cabbage and kale help to maintain a healthy gut and protect against colon cancer.

15 Aug 2018

New model of genetically engineered immune cells may help fight solid tumors

Scientists at Memorial Sloan Kettering Cancer Center announced that they have built a new model of genetically engineered immune cells in mice that may allow them to fight solid tumors.

15 Aug 2018

Scripps Research scientists uncover new approach for treating thrombocytopenia

Blood platelets are like the sand bags of the body. Got a cut? Platelets pile in to clog the hole and stop the bleeding.

15 Aug 2018

Researchers move closer to finding potential soft spot in drug-resistant tuberculosis

Antibiotic-resistant tuberculosis is a public health threat. TB and other bacteria become resistant to antibiotics by evolving genetic changes over time, which they can do quite quickly because bacterial lifecycles are short.

15 Aug 2018

New study focuses on promise of gene therapy for Amish nemaline myopathy

A new comprehensive natural history study about Amish nemaline myopathy in the Old Order Amish population focuses on the promise of gene therapy for this lethal disorder.

14 Aug 2018

Autoimmune response contributes to vision loss in glaucoma patients

A research team from Massachusetts Eye and Ear and MIT has shown that immune cells in the eye that developed in response to early exposure to bacteria are a key contributor to progressive vision loss from glaucoma, the second leading cause of irreversible blindness in the world.

10 Aug 2018

Defects in RNA modification can cause altered smooth muscle contraction

Genetic information is stored in DNA and is passed on in a very stable manner from one cell to the next or from one generation to the next.

9 Aug 2018

Scientists identify drug that could reverse pulmonary arterial hypertension

Scientists at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago took a major step toward developing a new treatment for pulmonary arterial hypertension, a severe lung disease with a five-year survival rate of 50 percent.

9 Aug 2018

Researchers identify role of infection-fighting cells in inflamed and damaged tissue

Hookworms infect nearly 430 million people in the world, mostly in countries where sanitation is poor, and people often walk barefoot.

7 Aug 2018

Doxorubicin drug causes heart toxicity by disrupting the immune system

Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure.

7 Aug 2018