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Concordia's subsidiary signs collaboration deal with Orphan Canada for PHOTOFRIN

Concordia Healthcare Corp., a diverse healthcare company focused on legacy pharmaceutical products, orphan drugs, and medical devices for the diabetic population, today announced that its subsidiary, Pinnacle Biologics, Inc., a biopharmaceutical research and development company specializing in rare diseases, has signed a collaboration agreement for PHOTOFRIN® with Orphan Canada, a Toronto-based specialty pharmaceutical company that in‐licenses therapies for rare disorders and specialty medicines within Canada.

2 Sep 2014

Thrombus aspiration for acute myocardial infarction does not reduce mortality

Thrombus aspiration for acute myocardial infarction (AMI) does not reduce mortality or other clinical endpoints long term, according to the awaited one-year follow-up results from the Thrombus Aspiration in ST- Elevation myocardial infarction in Scandinavia (TASTE) trial.

2 Sep 2014

FFR guided drug-eluting stenting reduces death compared to medical therapy in stable CAD patients

Fractional flow reserve (FFR)-guided drug-eluting stenting reduces death, myocardial infarction or urgent revascularisation, as compared to medical therapy in patients with stable coronary artery disease (CAD), according to the results of the FAME 2 trial presented for the first time today at ESC Congress by principal investigator Dr Bernard De Bruyne (Belgium).

2 Sep 2014

Two fully automated molecular testing systems for blood and plasma donor screening launched by Roche

Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today the commercial availability of the cobas 6800/8800 Systems, two integrated and fully automated molecular testing systems for blood and plasma donor screening, in markets accepting the CE mark. The cobas 6800/8800 Systems offer the fastest time to results with the highest throughput available, along with the longest walk-away time, enabling laboratory staff to drive increased workflow efficiencies, while adapting to their ever-changing testing demands.

From Roche Sequencing and Life Science 2 Sep 2014

Ambulance administration of antiplatelet medication may help heart attack patients

Ambulance administration of the antiplatelet medication ticagrelor to patients with a type of heart attack known as ST segment elevation myocardial infarction (STEMI) is not better than hospital administration, in terms of improving blood flow in blocked arteries before a revascularisation procedure, according to a new study presented at ESC Congress 2014 today.

2 Sep 2014

Risk of obesity higher among adults who had been subjected to abuse as children

Being subjected to abuse during childhood entails a markedly increased risk of developing obesity as an adult.

2 Sep 2014

Permanent atrial fibrillation twins risk of stroke than paroxysmal AF

Permanent atrial fibrillation (AF) doubles the risk of stroke compared to paroxysmal AF, according to research in more than 6 000 patients presented at ESC Congress today by Dr Thomas Vanassche from Belgium. The findings suggest that a simple clinical assessment of the type of AF can help doctors to better estimate stroke risk.

2 Sep 2014

Extracting Cardiac Leads: An Interview with Barry Norlander from Cook Medical

The pacemaker or ICD unit, which is the implanted box or generator i.e. the electrical component of the device that's implanted in the chest, usually lasts between seven to 10 years before the generator’s battery is depleted.

From COOK MEDICAL INC. 2 Sep 2014

Drugs plus biofeedback show promise for dysfunctional voiding

Research shows that the use of α1-blockers in combination with uroflowmetry biofeedback is more effective than either treatment alone for improving urinary symptoms and quality of life in women with dysfunctional voiding and recurrent urinary tract infection.

1 Sep 2014

‘Concerning’ rise in pneumococcus risk factors

Researchers report that the incidence of Streptococcus pneumoniae infection has fallen significantly in the USA in the past decade but describe a “concerning trend” whereby the baseline health status of those with serious pneumococcal disease has worsened.

1 Sep 2014

Alirocumab drug significantly improves cholesterol levels compared to ezetimibe

The investigational drug alirocumab significantly improved cholesterol levels compared to ezetimibe, when added to regular statin therapy in patients with high cholesterol and elevated risk of cardiovascular disease (CVD), according to the ODYSSEY COMBO II trial, presented as a Hot Line today at ESC Congress 2014.

1 Sep 2014

Scientists develop synthetic amino acid that can impact 3D structure of bioactive peptides

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side-effects to the patient. Such properties are directly related to the 3D structure of the drug molecule.

1 Sep 2014

Measuring coronary artery blockage in heart attack patients can help avoid surgery

A method for measuring coronary artery blockage in heart attack patients can help more than one fifth of them avoid stents or surgery, according to a British study presented at the ESC Congress 2014 today.

1 Sep 2014

Darapladib drug fails to reduce risk of recurrent major coronary events

In patients who experienced an acute coronary syndrome (ACS) event (such as heart attack or unstable angina), use of the drug darapladib to inhibit the enzyme lipoprotein-associated phospholipase A2 (believed to play a role in the development of atherosclerosis) did not reduce the risk of recurrent major coronary events, according to a study published by JAMA.

1 Sep 2014

Antihypertensive therapy decreases risk of mortality, CV events, strokes in older adults

Antihypertensive therapy reduces the risk of cardiovascular (CV) events, strokes and mortality in hypertensive older adults, according to research presented at ESC Congress 2014 today by Dr Maciej Ostrowski from Poland.

1 Sep 2014

Intravenous iron supplement can improve quality of life for iron deficient heart failure patients

Heart failure patients with iron deficiency can experience significant and sustainable improvements in functional capacity and quality of life as well as reduced risk of hospital admission for worsening heart failure by receiving just one to two intravenous doses of an iron supplement, according to the results of a study presented today at ESC Congress 2014.

30 Aug 2014

Investigational LCZ696 drug: A real breakthrough for patients with heart failure

An investigational new heart failure drug could be poised to change the face of cardiology based on Hot Line results presented today at ESC Congress 2014.

30 Aug 2014

Study compares FK506 and rapamycin for Schwann cell migration, peripheral nerve regeneration

FK506 possesses a well-studied neuroregenerative effect, stimulating neurite extension in the presence of nerve growth factor in vitro, and enhancing nerve regeneration following nerve crush injury and isografting.

30 Aug 2014

Researchers reveal how distinct areas of frontal lobes are critical for person's ability to learn

Until the last few decades, the frontal lobes of the brain were shrouded in mystery and erroneously thought of as nonessential for normal function-hence the frequent use of lobotomies in the early 20th century to treat psychiatric disorders.

30 Aug 2014

Preventing tentacle-like structures from forming can stop spread of cancer entirely

A new study from the research group of Dr. John Lewis at the University of Alberta (Edmonton, AB) and the Lawson Health Research Institute (London, ON) has confirmed that "invadopodia" play a key role in the spread of cancer. The study, published in Cell Reports, shows preventing these tentacle-like structures from forming can stop the spread of cancer entirely.

30 Aug 2014

Therapy News and Research

Concordia's subsidiary signs collaboration deal with Orphan Canada for PHOTOFRIN

Thrombus aspiration for acute myocardial infarction does not reduce mortality

FFR guided drug-eluting stenting reduces death compared to medical therapy in stable CAD patients

Two fully automated molecular testing systems for blood and plasma donor screening launched by Roche

Ambulance administration of antiplatelet medication may help heart attack patients

Risk of obesity higher among adults who had been subjected to abuse as children

Permanent atrial fibrillation twins risk of stroke than paroxysmal AF

Extracting Cardiac Leads: An Interview with Barry Norlander from Cook Medical

Drugs plus biofeedback show promise for dysfunctional voiding

‘Concerning’ rise in pneumococcus risk factors

Alirocumab drug significantly improves cholesterol levels compared to ezetimibe

Scientists develop synthetic amino acid that can impact 3D structure of bioactive peptides

Measuring coronary artery blockage in heart attack patients can help avoid surgery

Darapladib drug fails to reduce risk of recurrent major coronary events

Antihypertensive therapy decreases risk of mortality, CV events, strokes in older adults

Intravenous iron supplement can improve quality of life for iron deficient heart failure patients

Investigational LCZ696 drug: A real breakthrough for patients with heart failure

Study compares FK506 and rapamycin for Schwann cell migration, peripheral nerve regeneration

Researchers reveal how distinct areas of frontal lobes are critical for person's ability to learn

Preventing tentacle-like structures from forming can stop spread of cancer entirely

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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