Immune System News and Research

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QUANTUM trial tests immune-targeting approach for primary plasma cell leukemia

The Alliance for Clinical Trials in Oncology today announced the activation of The QUANTUM Trial (Alliance A062401), a clinical study designed to test a novel, immune-targeting approach for patients newly diagnosed with primary plasma cell leukemia (PCL).

30 Jul 2026

Biotherapeutic metabolite repairs gut damage caused by HIV infection

Researchers at the UC Davis School of Medicine have identified a naturally occurring metabolite that repairs gut damage caused by HIV infection and significantly improves the effectiveness of antiretroviral therapy (ART) in the nonhuman primate model of HIV/AIDS.

30 Jul 2026

Dual immunotherapy with neoadjuvant chemotherapy shows encouraging activity in ERBB2-negative breast cancer

A combination of two immunotherapy drugs showed encouraging activity when added to standard chemotherapy given prior to surgery for patients with high-risk, early-stage HER2-negative breast cancer, according to phase 2 clinical trial results from the ongoing I-SPY2 clinical trial platform.

30 Jul 2026

Medical breakthrough allows kidney transplant for patient with zero options

An international research team led by the Medical University of Vienna reports on a new treatment strategy that has made a kidney transplant possible for a patient with no realistic chance of receiving a suitable donor organ.

30 Jul 2026

Study questions antihistamine use for managing eczema symptoms

Adding oral antihistamines to existing eczema treatments is unlikely to lead to clinically important reductions in eczema and itch severity, and may not reduce sleep disturbance or flare-ups, finds a review of the latest trial evidence published by The BMJ today.

29 Jul 2026

Scientists discover why bats survive deadly viruses without getting sick

It is a mystery that has puzzled scientists for years. How can the world's only winged mammals carry viruses that cause severe disease while rarely becoming seriously ill themselves?

29 Jul 2026

NIH awards $2.4 million to study how maternal viral infections reprogram fetal immune development

The National Institute of Allergy and Infectious Diseases of the National Institutes of Health has awarded a new, five-year $2.4 million R01 grant to Dr. Jiahui Ding, assistant professor of obstetrics and gynecology at the Wayne State University School of Medicine's C.S. Mott Center for Human Growth and Development, to support research that aims to uncover how viral infections during pregnancy reprogram the developing immune system of the fetus, influencing susceptibility to infectious diseases throughout life.

29 Jul 2026

Overactive brain immune response linked to rare, severe genetic epilepsy

An overactive immune response in the brain may play a role in Dravet Syndrome, a rare and severe genetic epilepsy that typically begins in infancy, according to Weill Cornell Medicine researchers.

29 Jul 2026

Scientists discover why mouse liver cells resist hepatitis E virus

Mouse liver cells are not a suitable host for hepatitis E viruses. The Virology department in Bochum has discovered why.

29 Jul 2026

New strategy combines cancer immunotherapy and gene therapy in a single nanoparticle

Cancer cells survive by hiding from the immune system's surveillance. A KAIST research team has developed a new anticancer platform that makes cancer cells send out their own danger signal—prompting immune cells to attack—while simultaneously delivering gene therapy.

28 Jul 2026

Blocking autophagy in blood vessels reduces skin inflammation in mice

Researchers at VIB and KU Leuven, together with international collaborators, have discovered that blocking autophagy - the body's natural recycling system for worn-out cell components - in specialized blood vessels can reduce inflammation in mice with psoriasis.

28 Jul 2026

Too little or too much iodine may push immunity off balance

This narrative review finds that adequate iodine supports thyroid hormone signaling, leukocyte metabolism, antioxidant defenses, and antimicrobial activity in humans and domesticated mammals. Both deficiency and sustained excess may impair immunity or promote thyroid inflammation, but precise immune-specific intake thresholds remain uncertain.

27 Jul 2026

New cancer vaccine harnesses COVID-19 immune memory to fight tumors

In a discovery that could redefine the future of cancer immunotherapy, scientists from Celloram Inc., University Hospitals and Case Western Reserve University have developed a novel cancer vaccine platform that transforms the impact of the largest immunological event in modern history – a synchronized mass immune memory generated through SARS-CoV-2 infection and vaccination – into a powerful ally against cancer.

27 Jul 2026

Dengue virus infects memory B cells to evade immune defenses

Researchers at the University of Vermont Robert Larner, M.D. College of Medicine and Upstate Medical University in Syracuse, NY, have discovered that dengue virus can infect and replicate inside memory B cells, immune cells traditionally understood to help protect the body from infection.

27 Jul 2026

Duke University engineers use robots and AI to improve gut health

Biomedical engineers at Duke University have demonstrated a method for systematically developing novel, complex combinations of probiotics and prebiotics to more effectively maintain gut health and treat various gastrointestinal diseases.

27 Jul 2026

Engineered probiotic bacteria boost immune attack against pancreatic cancer

Cancer immunotherapies have transformed treatment for many cancers, but pancreatic cancer remains especially difficult to treat. One major reason is that pancreatic tumors often create a "cold" tumor microenvironment, where the tumor prevents immune cells from mounting a strong attack.

24 Jul 2026

Two microscopic parasites cause widespread diarrheal illness across America

You've seen the alarming headlines about parasites causing "explosive diarrhea" across the U.S. Two microscopic parasites – cyclospora cayetanensis and cryptosporidium – can both cause prolonged gastrointestinal illness, including watery diarrhea, stomach cramps, and dehydration.

24 Jul 2026

MEK inhibition could limit T cell exhaustion and give a boost to immunotherapy

A major pillar of cancer immunotherapy involves stimulating T cells, the specialized killers of the immune system, to attack tumors.

23 Jul 2026

Time zone changes disrupt vital gut bacteria during travel

A dream holiday, an exotic destination, a long-haul flight, and finally some well-deserved rest. The problem is that many travelers arrive at their destination only to spend the first days of their vacation struggling with fatigue, sleep disturbances, low energy levels, and digestive issues.

23 Jul 2026