Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Exosomes play a dual role in cancer progression and immune regulation

Tiny extracellular vesicles known as exosomes are emerging as key regulators of the tumor microenvironment (TME), influencing how cancer progresses, spreads, and responds to treatment.

7 Aug 2025

Early-onset pancreatic cancer patients benefit more from neoadjuvant chemotherapy and surgery

The incidence of early-onset pancreatic cancer (EOPC) is rising, yet optimal treatment strategies remain unclear.

7 Aug 2025

Targeting lactate metabolism offers new avenues for cancer treatment

Lactic acid (LA) has transitioned from being perceived as a mere glycolytic waste product to a pivotal regulator of tumor-immune crosstalk.

5 Aug 2025

Lipid droplet protein perilipin 2 linked to poor prognosis in lung cancer

New research has revealed that perilipin 2 protein modulates aggressive cancer progression in advanced lung adenocarcinoma, the most common type of lung cancer, by regulating lipid droplet accumulation, which plays an important role in lipid metabolism by making cancer cells store more fat, acting as a fuel source.

5 Aug 2025

Key protein found to guide melanoma cells during spread

Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body.

1 Aug 2025

New radioimmunotherapy approach eliminates cancer stem cells in preclinical models of ovarian cancer

A new radioimmunotherapy approach has been shown to successfully eliminate cancer stem cells (CSCs) in preclinical models of ovarian cancer, outperforming the current gold standard.

1 Aug 2025

Rethinking prostate cancer risk in GG1 diagnoses

A new study reveals that some men who are diagnosed with "Grade Group one" (GG1) prostate cancer may actually be at higher risk than biopsy results suggest, according to research led by Weill Cornell Medicine, University Hospitals Cleveland and Case Western University.

31 Jul 2025

Cancer-associated fibroblasts exhibit paradoxical effects on immunotherapy

Cancer-associated fibroblasts (CAFs) – critical but enigmatic players in tumors – exhibit "paradoxical" effects on immunotherapy, according to a new review in Clinical and Translational Discovery.

31 Jul 2025

Respiratory infections can reactivate dormant breast cancer cells

Researchers at the University of Colorado Anschutz Medical Campus, Montefiore Einstein Comprehensive Cancer Center (MECCC), and Utrecht University have found the first direct evidence that common respiratory infections, including COVID-19 and influenza, can awaken dormant breast cancer cells that have spread to the lungs, setting the stage for new metastatic tumors.

30 Jul 2025

Senescent macrophages emerge as key drivers of tumor progression

Macrophages are versatile immune cells, tasked with cleaning up pathogens and maintaining tissue health.

29 Jul 2025

NKAPL identified as a tumor suppressor and therapeutic target in NSCLC

Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases and is often diagnosed at advanced stages, limiting treatment options.

29 Jul 2025

Advancing precision medicine in colorectal cancer with multi-omics approaches

Colorectal cancer is among the most prevalent and lethal malignancies worldwide, with liver metastases occurring in nearly one-third of patients and accounting for a major share of cancer-related deaths.

28 Jul 2025

Neutrophils emerge as key players in cancer progression and therapy

Neutrophils are the most abundant type of white blood cells, critical for immune defense and inflammation control.

28 Jul 2025

Blocking nutrient scavenging weakens pancreatic tumor defenses

Cancer cells and tumors do not exist in a vacuum. Far from the isolation and self-sufficiency of the fictional Wakanda, tumors develop in and alter the nearby milieu of immune cells, connective tissue, blood vessels and a sea of proteins and carbohydrates that provide structure and other supportive functions.

24 Jul 2025

Cuproptosis offers new hope for treating inflammatory bowel disease and colorectal cancer

Cuproptosis represents a novel mechanism of cell death characterized by intracellular copper ion accumulation.

18 Jul 2025

Research uncovers role of whole-genome doubling in ovarian cancer evolution

Research led by Memorial Sloan Kettering Cancer Center (MSK) is shedding new light on how ovarian cancer evolves - insights that could help researchers develop more effective treatment strategies.

17 Jul 2025

Computational biology unlocks rules of tissue self-organization

A team of researchers at ChristianaCare's Helen F. Graham Cancer Center & Research Institute and the University of Delaware believe they've found an answer.

15 Jul 2025

Pathogenic mechanisms of Fusobacterium nucleatum in colorectal cancer and emerging therapies

In recent years, the regulatory role of the gut microbiota in the initiation and progression of colorectal cancer (CRC) has attracted growing attention. Among the key microbial contributors, Fusobacterium nucleatum (Fn) has been identified as a critical pathogenic factor in CRC.

12 Jul 2025

Psychological stress drives ovarian tumor metastasis through NR3C1 and NUPR1

This new article publication from Acta Pharmaceutica Sinica B, discusses how a psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis.

10 Jul 2025

Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness

In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine say they have shed new light on the location and function of power-generating waves on the covering, or membrane, of these cells.

9 Jul 2025