Nucleotides News and Research

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Genetic characteristics of possible new Alphacoronavirus species found in Bats

A recent study identifies a novel Alphacoronavirus isolated from bats, in Korea, in 2020.

13 Oct 2021

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Researchers in Germany have developed a promising approach to suppressing the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

12 Oct 2021

CAST brings advancements in genomic medicine to admixed individuals

One way to make health care more personalized is to use a person's DNA sequence — or genome — to predict their risk of disease. But as the field of precision medicine grows, so have concerns that we may be leaving a large fraction of Americans out.

12 Oct 2021

Exosomal and non-exosomal miRNAs may serve as biomarkers for HCV-related cirrhosis, liver cancer

Oncotarget published "Exosomal and non-exosomal miRNA expression levels in patients with HCV-related cirrhosis and liver cancer" which reported that patients with HCV-related cirrhosis are at risk for liver cancer development.

11 Oct 2021

Elucidating the natural spillover theory on the SARS-CoV-2 emergence

To determine whether SARS-CoV-2 resulted from a natural spillover into humans, researchers discuss the veracity of early SARS-CoV-2 lineages.

4 Oct 2021

Research points to new opportunities to prevent treatment resistance in fragile X syndrome

Mark Bear, Picower Professor of Neuroscience at MIT, recalls the "eureka moment" 20 years ago when he realized that a severe developmental brain disorder - fragile X syndrome - might be treated with drugs that inhibit a neurotransmitter receptor called mGluR5.

29 Sep 2021

Research reveals nucleolar RNA interference based on C. elegans as a model organism

A research group led by Prof. GUANG Shouhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. FENG Xuezhu from the First Affiliated Hospital of USTC, revealed the nucleolar RNA interference based on Caenorhabditis elegans (C. elegans) as a model organism. The study was published in Nuclear Acids Research.

28 Sep 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

Researchers describe a novel role for hnRNP E1 protein in binding DNA in the nucleus

Cancer is a devastating disease and is the second leading cause of death in the U.S. One of the hallmarks of cancer is genomic instability, or the tendency to accumulate mutations and damage to the DNA that leads to genome alterations during cell division.

25 Sep 2021

New cell-free antibody generation platform successfully creates neutralizing antibodies effective against SARS-CoV-2

Researchers from the Broad Institute of MIT and Harvard have created a cell-free nanobody engineering platform that can produce antibodies effectively and quickly.

21 Sep 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

New SARS-CoV-2 mechanism of host gene suppression

A new study finds that the viral non-coding RNA dubbed vmiR-5p, derived from the viral gene ORF7a, appears to reduce host transcription.

13 Sep 2021

Breakthrough study could lead to much needed therapies for Huntington's disease

A new mechanism that stops the progression of Huntington's disease in cells has been identified by scientists at UCL and the University of Cambridge, as part of their research groups at the UK Dementia Research Institute.

31 Aug 2021

Antisense oligonucleotides engineered to inhibit SARS-CoV-2

In a paper recently uploaded to the bioRxiv* preprint server, structure-based ASOs are developed against SARS-CoV-2, intended to bond with RNA in its structured in situ form, rather than the more rarely encountered linear section, achieving greater affinity and specificity than linear ASOs, and demonstrating inhibition of virus replication in human cells.

30 Aug 2021

New machine learning method enhances computational prediction of RNA structures

Researchers present ARES (Atomic Rotationally Equivariant Scorer) – a machine learning method that significantly improves the computational prediction of RNA structures over previous approaches. Like proteins, RNA molecules twist and fold into intricate three-dimensional shapes that are crucial to their function.

27 Aug 2021

Nucleotides News and Research

Genetic characteristics of possible new Alphacoronavirus species found in Bats

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

CAST brings advancements in genomic medicine to admixed individuals

Exosomal and non-exosomal miRNAs may serve as biomarkers for HCV-related cirrhosis, liver cancer

Elucidating the natural spillover theory on the SARS-CoV-2 emergence

Research points to new opportunities to prevent treatment resistance in fragile X syndrome

Research reveals nucleolar RNA interference based on C. elegans as a model organism

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

Researchers describe a novel role for hnRNP E1 protein in binding DNA in the nucleus

New cell-free antibody generation platform successfully creates neutralizing antibodies effective against SARS-CoV-2

Drug accumulation alters gut bacterial metabolism and composition

New SARS-CoV-2 mechanism of host gene suppression

Breakthrough study could lead to much needed therapies for Huntington's disease

Antisense oligonucleotides engineered to inhibit SARS-CoV-2

New machine learning method enhances computational prediction of RNA structures

New study identifies novel compound as promising pan-coronavirus drug candidate

Study uncovers a subset of human short introns spliced out by a distinct mechanism

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

Research suggests potential new treatment strategy for phenylketonuria

Finding potential microRNAs from humans and plants against SARS-CoV-2

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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