Restenosis News and Research

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Restenosis means the reoccurrence of stenosis, a narrowing of a blood vessel, leading to restricted blood flow. Restenosis usually pertains to an artery or other large blood vessel that has become narrowed, received treatment to clear the blockage and subsequently become renarrowed. This is usually restenosis of an artery, or other blood vessel, or possibly a vessel within an organ.

New research may solve problem of vessels re-closing after angioplasty

Through studying pigeons with genetic heart disease, researchers at Wake Forest University School of Medicine have discovered a clue about why some patients' heart vessels are prone to close back up after angioplasty.

6 Aug 2006

Australian researchers find key 'go-betweeen' in heart disease

Medical researchers at the University of New South Wales (UNSW) - Australia, have shed light on a little-known mechanism involved in the thickening of arteries, a process associated with heart disease.

13 Mar 2006

Sirolimus-releasing stents more effective than vascular brachytherapy for treating restenosis within a stent

David R. Holmes, Jr., M.D., of Mayo Clinic, Rochester, Minn., and colleagues with the SISR trial compared the use of vascular brachytherapy (VBT - intra-coronary radiation therapy) with implantation of the sirolimus-eluting stent for the treatment of restenosis occurring within a previously placed bare-metal stent

13 Mar 2006

Stents that release the drug paclitaxel to treat stenosis more effective than radiation therapy

Insertion of stents that release the drug paclitaxel to treat stenosis within an implanted bare-metal stent in a coronary artery reduces the risk of subsequent re-narrowing within the stent, when compared with treatment using intra-coronary radiation

13 Mar 2006

Drug-eluting stents best treatment for managing coronary restenosis

In the first published trial of its kind, a multi-center clinical study has shown that drug-eluting stents outperform the current "gold standard" radiation treatment in managing coronary restenosis and in preventing further clogging of coronary arteries.

13 Mar 2006

Bone marrow stem cells do not improve cardiac function in heart attack patients

There has been increasing evidence that stem cells contribute to regeneration of cardiac tissue and the development of new blood vessels following a heart attack, thus opening up new prospects for stem-cell based therapies.

1 Mar 2006

Coronary stents that release the drugs sirolimus or paclitaxel produce similar results

Use of coronary stents that release the drugs sirolimus or paclitaxel produced similar results in patients with new coronary artery lesions, according to a study in JAMA: The Journal of the American Medical Association.

24 Feb 2006

GRK5's role in restenosis

Researchers at Jefferson Medical College have begun to clarify the role of a protein - and potential drug target - in the process by which arteries re-clog after treatment.

28 Nov 2005

Drug-eluting stents significantly cut the rates of heart attack and repeat procedures

The use of medicated stents markedly improves the clinical outcomes of patients who develop blockages in aging veins surgically grafted onto the heart, according to a just-published study in the November 2005 issue of Catheterization and Cardiovascular Interventions: Journal of the Society for Cardiovascular Angiography and Interventions.

18 Oct 2005

New trend in treating heart disease in diabetics - angioplasty using the Cypher Sirolimus-eluting coronary stent

The World Health Organisation has predicted an increase in the worldwide prevalence of diabetes of epidemic proportions . Eighty percent of people with diabetes will die from cardiovascular complications -- stroke and/or coronary heart disease (CHD).

12 May 2005

Coronary artery stents that release medication appear more effective than traditional stents for patients with heart attack

A type of coronary artery stent that releases a medication appears to result in better outcomes than traditional stents for heart attack patients, according to a study in the May 4 issue of JAMA.

3 May 2005

Women respond as well as men to treatment with drug-eluting stents

Despite the fact that symptomatic coronary disease afflicts men and women equally, only 33 percent of the 1.2 million interventional procedures conducted in the U.S. each year are done on women.

19 Apr 2005

Drug eluting stents as effective as vascular brachytherapy in preventing restenosis

After angioplasty is performed to widen clogged arteries, surgeons frequently use tiny wire-mesh tubes called stents to keep blood vessels open. But despite stenting, scar tissue can form to create new blockages -- a process called in-stent restenosis (ISR).

7 Mar 2005

Use of cilostazol, clopidogrel and aspirin results in a significant reduction of thrombotic complications in the prevention of heart attacks

Three drugs, each of which works in a different way, are used in anti-platelet therapy to help prevent restenosis (the reclogging of blood vessels after they have been cleared with percutaneous coronary intervention or PCI) or thrombosis (obstruction of an artery or vein by a blood clot).

7 Mar 2005

Adenosine Therapeutics awarded grant to develop drug eluting stents to prevent restenosis

Adenosine Therapeutics announced today the award of a Phase II Small Business Innovation Research (SBIR) grant from the National Institutes of Health.

6 Dec 2004

Sirolimus drug-coated stent causes less inflammation than bare metal stents

In the treatment of coronary artery disease, a sirolimus drug-coated stent causes less inflammation than bare metal stents, according to preliminary research presented at the American Heart Association annual meeting by Loyola University Health System, Maywood, Ill.

11 Nov 2004

Coronary stents have no impact on mortality over the long term

While the placement of stents in newly reopened coronary arteries has been shown to reduce the need for repeat angioplasty procedures, researchers from the Duke Clinical Research Institute have found that stents have no impact on mortality over the long term.

8 Nov 2004

Breakthrough discovery in treating narrowed arteries

A breakthrough discovery by Heart and Stroke Foundation researcher Dr. Michael Kutryk that harnesses the body’s own natural defenses to fight narrowing of the arteries has been recognized as “a glimpse into the future” and “potentially one of the biggest advances in cardiology to date”.

25 Oct 2004

Rosiglitazone helps boost the effectiveness of a treatment for opening clogged arteries

Rosiglitazone, a drug taken to help improve blood sugar levels, also helps boost the effectiveness of a treatment for opening clogged arteries, according to a study in the November issue of Diabetes Care.

25 Oct 2004

Moderate alcohol consumption cuts rate of further narrowing after heart surgery

New German research from Heidelberg University suggests that moderate drinking cuts the rate of further narrowing after surgery to open blocked arteries. The findings are published in the current issue of Heart.

12 Sep 2004

Restenosis News and Research

Further Reading

New research may solve problem of vessels re-closing after angioplasty

Australian researchers find key 'go-betweeen' in heart disease

Sirolimus-releasing stents more effective than vascular brachytherapy for treating restenosis within a stent

Stents that release the drug paclitaxel to treat stenosis more effective than radiation therapy

Drug-eluting stents best treatment for managing coronary restenosis

Bone marrow stem cells do not improve cardiac function in heart attack patients

Coronary stents that release the drugs sirolimus or paclitaxel produce similar results

GRK5's role in restenosis

Drug-eluting stents significantly cut the rates of heart attack and repeat procedures

New trend in treating heart disease in diabetics - angioplasty using the Cypher Sirolimus-eluting coronary stent

Coronary artery stents that release medication appear more effective than traditional stents for patients with heart attack

Women respond as well as men to treatment with drug-eluting stents

Drug eluting stents as effective as vascular brachytherapy in preventing restenosis

Use of cilostazol, clopidogrel and aspirin results in a significant reduction of thrombotic complications in the prevention of heart attacks

Adenosine Therapeutics awarded grant to develop drug eluting stents to prevent restenosis

Sirolimus drug-coated stent causes less inflammation than bare metal stents

Coronary stents have no impact on mortality over the long term

Breakthrough discovery in treating narrowed arteries

Rosiglitazone helps boost the effectiveness of a treatment for opening clogged arteries

Moderate alcohol consumption cuts rate of further narrowing after heart surgery

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