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COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Newly discovered antibody appears to block infection by all dominant variants of SARS-CoV-2 virus

A team led by researchers at Weill Cornell Medicine, the University of Wisconsin-Madison; Scripps Research and the University of Chicago has identified an antibody that appears to block infection by all dominant variants of the virus that causes COVID-19, including Omicron, the most recent.

7 Apr 2023

Nasal SARS-CoV-2 vaccine outperforms existing vaccines in preclinical trial

Researchers assess the role of the live-attenuated vaccine sCPD9 in inducing systemic and mucosal immunity against SARS-CoV-2 variants.

6 Apr 2023

Study explores the species-specific use of ACE2 receptors by human and animal coronaviruses

Researchers assessed the ability of spike proteins from 24 animal or human coronaviruses to utilize angiotensin-converting enzyme 2.

5 Apr 2023

Study suggests psychosocial factors, not acute infections, contribute to long-COVID in young adults

Researchers investigated the prevalence of post-coronavirus disease 2019 condition in adolescents and young adults

4 Apr 2023

Live attenuated nasal vaccine elicits superior immunity to SARS-CoV-2 variants in hamsters

Since the beginning of the COVID-19 pandemic, researchers have been working on mucosal vaccines that can be administered through the nose.

4 Apr 2023

Spike protein could be responsible for memory loss in post-COVID-19 syndrome

Patients diagnosed with post-COVID-19 syndrome often experience cognitive and memory impairments. A new study by researchers from the Federal University of Rio de Janeiro (UFRJ) and UniRio provides insight into the mechanism behind this phenomenon.

3 Apr 2023

Red blood cell hitch-hiking facilitates SARS-CoV-2 multi-organ spread

Researchers assessed the infectious capacity of severe acute respiratory syndrome coronavirus 2 in plasma and red blood cells.

3 Apr 2023

Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Researchers screened the circulating B lymphocyte repertoires of coronavirus disease 2019 convalescents and vaccines using multiplexed antigen panels.

3 Apr 2023

Tighter core of SARS-CoV-2 spike protein in new variants may have increased the virus's fitness

Just as a tight core is a component of good physical fitness for humans, helping to stabilize our bodies, mutations that tightened the core of the SARS-CoV-2 spike protein in new variants may have increased the virus's fitness.

31 Mar 2023

What is the effect of prior BCG vaccination on the immunogenicity and efficacy of subsequent COVID-19 vaccination?

Researchers assessed the impact of BCG vaccination on the protection provided by SARS-CoV-2 vaccination.

28 Mar 2023

Nasally administered molecule effective in preventing all SARS-CoV-2 variants

Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of the SARS-CoV-2 virus.

24 Mar 2023

SARS-CoV-2 infection damages CD8+ T cell response

In a recent study published in the journal Immunity, a team of researchers from the United States found that previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections reduce the activation and expansion of CD8+ T cells in response to coronavirus disease 2019 (COVID-19) vaccinations.

22 Mar 2023

SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

Researchers assess SARS-CoV-2 spike protein-specific immunological memory among unvaccinated and vaccinated convalescents.

22 Mar 2023

Study reveals why COVID-19 subvariants spread rapidly among previously infected people

The COVID-19 pandemic has killed nearly 7 million people worldwide (1.1 million in the United States) and severely harmed many millions more, though vaccines and antiviral treatments measurably reduced the potential loss of life and health.

22 Mar 2023

Low-cost, universal oral COVID-19 vaccine prevents severe respiratory illness in hamsters

A UCLA-led team has developed an inexpensive, universal oral COVID-19 vaccine that prevented severe respiratory illness and weight loss when tested in hamsters, which are naturally susceptible to SARS-CoV-2.

22 Mar 2023

Prior COVID and vaccination generate superior hybrid immunity

In a recent article published in the journal Science Translational Medicine, researchers in France performed a long-term longitudinal analysis to demonstrate the benefits of hybrid immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), i.e., induced by viral infection followed by vaccination.

21 Mar 2023

SARS-CoV-2 infection damages the CD8+ T cell response to vaccination

The magnitude and quality of a key immune cell's response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found.

20 Mar 2023

Biomarkers that can predict long COVID symptoms

The current study offered novel insights into the different biological factors that might contribute to long COVID.

19 Mar 2023

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell receptor heavy chain are responsible for broadening its specificity for unexposed antigens.

16 Mar 2023

Spike Protein News and Research

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Newly discovered antibody appears to block infection by all dominant variants of SARS-CoV-2 virus

Nasal SARS-CoV-2 vaccine outperforms existing vaccines in preclinical trial

Study explores the species-specific use of ACE2 receptors by human and animal coronaviruses

Study suggests psychosocial factors, not acute infections, contribute to long-COVID in young adults

Live attenuated nasal vaccine elicits superior immunity to SARS-CoV-2 variants in hamsters

Spike protein could be responsible for memory loss in post-COVID-19 syndrome

Red blood cell hitch-hiking facilitates SARS-CoV-2 multi-organ spread

Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Tighter core of SARS-CoV-2 spike protein in new variants may have increased the virus's fitness

What is the effect of prior BCG vaccination on the immunogenicity and efficacy of subsequent COVID-19 vaccination?

Nasally administered molecule effective in preventing all SARS-CoV-2 variants

SARS-CoV-2 infection damages CD8+ T cell response

SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

Study reveals why COVID-19 subvariants spread rapidly among previously infected people

Low-cost, universal oral COVID-19 vaccine prevents severe respiratory illness in hamsters

Prior COVID and vaccination generate superior hybrid immunity

SARS-CoV-2 infection damages the CD8+ T cell response to vaccination

Biomarkers that can predict long COVID symptoms

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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