Cell Death News and Research

RSS

Moffitt researchers develop mathematical model to show differences in subpopulations of tumors

Tumors are composed of many subpopulations of cells. A general consensus among scientists is that these subpopulations are due to random mutations. However, Moffitt Cancer Center researchers found that these assumptions may be incorrect.

22 Jun 2016

Highly efficient bacterial agent could improve treatment of Wilson disease

In the 'Journal of Clinical Investigation', scientists at the Helmholtz Zentrum München describe a small peptide that very efficiently binds excess copper from liver cells. This molecule comes from a bacterium's bag of tricks and could be suitable for treating Wilson disease.

21 Jun 2016

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge, led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3-kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

17 Jun 2016

Already-approved drugs can fight apoptosis evasion in cancer

Cancer cells don't die when they're supposed to. Animal and human bodies follow an orderly process of birthing new cells and killing old ones. But cancer cells escape programmed cell death, called apoptosis, and multiply uncontrollably.

15 Jun 2016

Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Cisplatin is a common, powerful chemotherapy agent used for a wide range of cancers such as breast, ovarian and lung, that in a handful of days can also permanently damage or destroy patients' kidneys.

14 Jun 2016

Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

A new study suggests that blocking an enzyme called PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer.

14 Jun 2016

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo.

9 Jun 2016

Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

The metabolite of a drug that is helping patients battle multiple sclerosis appears to significantly slow the onset of Parkinson's disease, researchers say.

9 Jun 2016

Research shows IFITM3 protein can block Zika virus from infecting human, mouse cells

Eight weeks after receiving their first samples of Zika virus, scientists at the University of Massachusetts Medical School have shown that a very small protein we all have in our bodies, interferon-induced protein 3 (IFITM3), can dramatically reduce the ability of Zika virus to infect human and mouse cells.

6 Jun 2016

Fasnall drug appears to inhibit tumor growth by promoting cancer cell death

A promising new compound appears to impede a process that fuels breast cancer in mice, a discovery that could have implications in the treatment of a host of cancers.

3 Jun 2016

Buck researchers identify new, potential drug targets for sporadic PD

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally.

2 Jun 2016

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

A protein designed by researchers at Georgia State University can effectively target a cell surface receptor linked to a number of diseases, showing potential as a therapeutic treatment for an array of illnesses, including cancer, according to the research team.

1 Jun 2016

Novel way of directly activating Bak protein can trigger cell death

Melbourne researchers have discovered a new way of triggering cell death, in a finding that could lead to drugs to treat cancer and autoimmune disease.

27 May 2016

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors.

27 May 2016

RBFOX2 dysregulation may cause heart damage in diabetic patients

Cardiac complications are the number one cause of death among diabetics. Now a team of scientists has uncovered a molecular mechanism involved in a common form of heart damage found in people with diabetes.

27 May 2016

Clinical trials of anti-cancer agent PAC-1 continue to progress with anonymous funding

Clinical trials of the anti-cancer agent PAC-1 are continuing to expand, thanks to a $7 million angel investment from an anonymous contributor who originally invested $4 million to help get the compound this far in the drug-approval pipeline.

25 May 2016

Researchers identify potential ways in which cancer cells may develop resistance to BET inhibitors

A team of Walter and Eliza Hall Institute researchers has worked out how a new class of anti-cancer drugs kills cancer cells, a finding that helps explain how cancer cells may become resistant to treatment.

23 May 2016

New way of understanding neurodegeneration may lead to novel treatments

University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.

13 May 2016

Mouse models of Zika virus infection in pregnancy provide basis to develop vaccines, treatments

Two mouse models of Zika virus infection in pregnancy have been developed by a team of researchers at Washington University School of Medicine in St. Louis. In them, the virus migrated from the pregnant mouse's bloodstream into the placenta, where it multiplied, then spread into the fetal circulation and infected the brains of the developing pups.

12 May 2016

Brazilian strain of Zika virus can cause severe birth defects

Researchers at University of California San Diego School of Medicine, with colleagues in Brazil and Senegal, have described the first "direct experimental proof" that the Brazilian strain of Zika virus can actually cause severe birth defects. The findings are published in the May 11 online issue of Nature.

12 May 2016

Cell Death News and Research

Moffitt researchers develop mathematical model to show differences in subpopulations of tumors

Highly efficient bacterial agent could improve treatment of Wilson disease

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Already-approved drugs can fight apoptosis evasion in cancer

Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

Research shows IFITM3 protein can block Zika virus from infecting human, mouse cells

Fasnall drug appears to inhibit tumor growth by promoting cancer cell death

Buck researchers identify new, potential drug targets for sporadic PD

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

Novel way of directly activating Bak protein can trigger cell death

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

RBFOX2 dysregulation may cause heart damage in diabetic patients

Clinical trials of anti-cancer agent PAC-1 continue to progress with anonymous funding

Researchers identify potential ways in which cancer cells may develop resistance to BET inhibitors

New way of understanding neurodegeneration may lead to novel treatments

Mouse models of Zika virus infection in pregnancy provide basis to develop vaccines, treatments

Brazilian strain of Zika virus can cause severe birth defects

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics