Clinical Trial News and Research

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IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

Almost all postmenopausal patients aged 50-69 years with stage I hormone receptor (HR)-positive breast cancer and low scores on a common genetic test who opted out of adjuvant radiotherapy were disease free five years after surgery, according to results from the IDEA clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

7 Dec 2023

New research may pave the way for treatment of vaginal yeast infections

New research could one day pave the way for the treatment of vaginal yeast infections, by shedding new light on how microbes in the body absorb zinc.

6 Dec 2023

Blocking an allergy pathway unleashes antitumor immunity in mouse models of non-small cell lung cancer

Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC).

6 Dec 2023

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Military personnel repeatedly exposed to blasts show increased brain inflammation and structural changes

The brains of special warfare community personnel repeatedly exposed to blasts show increased inflammation and structural changes compared with a control group, potentially increasing the risk of long-term, brain-related disease, according to a new study.

6 Dec 2023

Twice daily electrical stimulation boosts brain plasticity and improves memory in Alzheimer's patients

Twice daily non-invasive electrical stimulation of the brain may boost mental processes (cognitive function) in people with Alzheimer's disease, suggest the results of a small clinical trial published online in the open access journal General Psychiatry.

6 Dec 2023

Brain stimulation offers promise for prospective memory deficits in schizophrenia

Most people with schizophrenia have extensive impairment of memory, including prospective memory, which is the ability to remember to perform future activities.

6 Dec 2023

Early tonsil and adenoids removal improves sleep quality and behavior in children

The surgery did not improve the children's neurodevelopmental functioning but was associated with improved quality of life, sleep symptoms, and blood pressure 12-months post-surgery according to a randomized control trial led by researchers at Brigham and Women's Hospital and the Harvard Pilgrim Health Care Institute.

5 Dec 2023

Study: 90% of pregnant women lack key vitamins necessary for healthy pregnancies and infant wellbeing

Pregnant women are not getting the essential nutrients they and their babies need from modern diets say scientists, who have warned that the situation will likely worsen as more people turn to plant-based foods.

5 Dec 2023

Trial addresses the effects of adenotonsillectomy on children with mild sleep-disordered breathing

Surgical removal of the tonsils and adenoids in children with snoring and mild breathing problems during sleep appears to improve their sleep, quality of life, and blood pressure a year after surgery, a clinical trial supported by the National Institutes of Health has found.

5 Dec 2023

The past, present and future of automation and digitalization in the life sciences laboratory

In this interview, News-Medical talks to Dr. Klaus Lun and Chris Mason about the past, present and future of automation and digitalization in the life sciences laboratory and especially the impact this could have on next-generation sequencing and genomics.

From Tecan 5 Dec 2023

Can ketogenic diet offer an effective alternative to antiseizure medication in infants with drug-resistant epilepsy?

The effectiveness of ketogenic diets in lowering seizure frequency among newborns.

5 Dec 2023

Experimental deep brain stimulation offers hope to treat cognitive deficits after traumatic brain injuries

Five people who had life-altering, seemingly irreversible cognitive deficits following moderate to severe traumatic brain injuries showed substantial improvements in their cognition and quality of life after receiving an experimental form of deep brain stimulation (DBS) in a phase 1 clinical trial.

4 Dec 2023

Researchers evaluate performance of a large language model in phenotyping postpartum hemorrhage patients

Researchers evaluated the performance of a large language model (LLM) in phenotyping postpartum hemorrhage (PPH) patients using discharge notes.

4 Dec 2023

Navigating STXBP1-related disorders: Unraveling clinical and developmental outcomes

Researchers examined the combined patient-years of seizure and developmental histories in individuals with disorders related to the STXBP1 gene.

4 Dec 2023

New adaptive clinical trial aims to reverse neurological damage caused by progressive multiple sclerosis

The first-ever adaptive clinical trial for Australians living with MS will seek to reverse neurological damage caused by progressive multiple sclerosis.

4 Dec 2023

AI transforms colonoscopy: Boosting detection rates, slashing miss rates in cancer screening

Researchers in China have demonstrated through a systematic review and meta-analysis that AI-based methods significantly enhance adenoma detection rates and reduce miss rates during colonoscopies, potentially improving colorectal cancer screening and reducing mortality.

3 Dec 2023

$Vitamin D supplementation fails to prevent fractures in children$

Vitamin D supplementation fails to prevent fractures in children

A major clinical trial led by Queen Mary University of London and the Harvard T.H. Chan School of Public Health has found that vitamin D supplements do not increase bone strength or prevent bone fractures in children with vitamin D deficiency.

1 Dec 2023

Texas Children's Hospital delivers first-ever gene therapy for Rett syndrome

Texas Children's Hospital, an internationally-recognized, top-ranked children's hospital and pediatric research center affiliated with Baylor College of Medicine, is the first to deliver a novel gene therapy to treat Rett syndrome in pediatric patients.

1 Dec 2023

Lung-MAP: A beacon of hope for lung cancer patients

The unique public-private partnership that for almost a decade has undergirded the first National Cancer Institute (NCI)-sponsored precision medicine clinical trial in lung cancer can serve as a model for future clinical research that is more rapid, innovative, and inclusive.

1 Dec 2023

Clinical Trial News and Research

IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

New research may pave the way for treatment of vaginal yeast infections

Blocking an allergy pathway unleashes antitumor immunity in mouse models of non-small cell lung cancer

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

Military personnel repeatedly exposed to blasts show increased brain inflammation and structural changes

Twice daily electrical stimulation boosts brain plasticity and improves memory in Alzheimer's patients

Brain stimulation offers promise for prospective memory deficits in schizophrenia

Early tonsil and adenoids removal improves sleep quality and behavior in children

Study: 90% of pregnant women lack key vitamins necessary for healthy pregnancies and infant wellbeing

Trial addresses the effects of adenotonsillectomy on children with mild sleep-disordered breathing

The past, present and future of automation and digitalization in the life sciences laboratory

Can ketogenic diet offer an effective alternative to antiseizure medication in infants with drug-resistant epilepsy?

Experimental deep brain stimulation offers hope to treat cognitive deficits after traumatic brain injuries

Researchers evaluate performance of a large language model in phenotyping postpartum hemorrhage patients

Navigating STXBP1-related disorders: Unraveling clinical and developmental outcomes

New adaptive clinical trial aims to reverse neurological damage caused by progressive multiple sclerosis

AI transforms colonoscopy: Boosting detection rates, slashing miss rates in cancer screening

Vitamin D supplementation fails to prevent fractures in children

Texas Children's Hospital delivers first-ever gene therapy for Rett syndrome

Lung-MAP: A beacon of hope for lung cancer patients

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