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Innate and adaptive immune responses to SARS-CoV-2 infection in older golden hamsters

Researchers assessed the variation in SARS-CoV-2 manifestation with age.

13 Jun 2022

SARS-CoV-2 BA.4/5 variants escape vaccine and BA.1 infection induced antibodies

In a recent work published in the Cell journal, investigators examined the severe acute respiratory syndrome coronavirus (SARS-CoV-2) Omicron BA.5/4 variants escape from neutralizing antibodies induced by SARS-CoV-2 vaccines and natural infection.

13 Jun 2022

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

In a recent study published in the journal PNAS, researchers demonstrated higher comparative efficacy of the intranasal (IN) route of coronavirus disease 2019 (COVID-19) vaccine administration versus intramuscular route in mice.

12 Jun 2022

Co-circulation of adenovirus 40/41 and SARS-CoV-2 and emergence of hepatitis cases in children

In a recent study posted to the medRxiv* pre-print server, KU Leuven researchers investigated whether there was an association between the intensity of the co-circulation of adenovirus (AdV) 40/41 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with the number of hepatitis cases of unknown origin emerging in Belgium.

12 Jun 2022

Study investigates SARS-CoV-2 escape from nirmatrelvir

Researchers assessed SARS-CoV-2 Alpha, Delta, and Omicron variants’ resistance to nirmatrelvir, a protease inhibitor of SARS-CoV-2.

10 Jun 2022

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

A drug used to target IDH1 mutations in select cancers also appears to inhibit the wild-type form of the enzyme, under certain conditions.

9 Jun 2022

Targeting fatty acid metabolism holds promise for Parkinson's disease

The human brain is lipid rich. Lipids and fatty acids contribute to many important cellular processes. Alpha-synuclein - a protein that plays a critical role in Parkinson's disease (PD) - is known to interact with and alter the balance of lipids and fatty acids.

9 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Longitudinal kinetics of the serological response in COVID-19 recovered patients over a period of 14 months

Researchers assessed the proportion of receptor-binding domain antibodies in COVID-19-recovered patients.

8 Jun 2022

Researchers develop new chemical-only process for creating customized mRNA vaccines

Researchers at Nagoya University in Japan have developed a new chemical-only process that may represent an important breakthrough in creating customized mRNA vaccines for a variety of diseases and allow for the inexpensive preparation of mRNA in large quantities.

8 Jun 2022

A new coronavirus found in Swedish bank voles

Researchers report the discovery of the Gimso virus, a novel betacoronavirus in a bank vole from Grimso, Sweden

7 Jun 2022

Gastrointestinal complications caused by SARS-CoV-2

scientists discuss the gastrointestinal complications associated with COVID-19.

7 Jun 2022

USC scientists receive more than $16 million to study the role of blood vessel dysfunction in Alzheimer’s disease

The National Institute on Aging, a division of the National Institutes of Health, awarded Berislav Zlokovic, MD, PhD, director of the Zilkha Neurogenetic Institute, and Arthur W. Toga, PhD, director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI), $16.1 million to continue research on the role that blood vessel dysfunction plays in the development of dementia and Alzheimer's disease.

7 Jun 2022

De novo-designed mini-protein against SARS-CoV-2

Researchers characterized truncated forms of LCB1, a de novo-designed mini-protein, against SARS-CoV-2.

7 Jun 2022

Omicron lineage spike proteins use ACE2 receptors more efficiently

A recent study posted to the bioRxiv* preprint server demonstrated various traits, including the entry pathways and sensitivity to vaccination-elicited antibody responses by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants.

7 Jun 2022

Drug combination yields highest response and longest survival rates for patients with pancreatic NETs

Very few treatment options are available to patients with advanced pancreatic neuroendocrine tumors (NETs), but researchers at the Yale Cancer Center and Yale New Haven Health's Smilow Cancer Hospital found that patients treated with a combination of capecitabine and temozolomide had longer progression-free survival rates than those treated with temozolomide alone.

6 Jun 2022

Enzyme News and Research

Innate and adaptive immune responses to SARS-CoV-2 infection in older golden hamsters

SARS-CoV-2 BA.4/5 variants escape vaccine and BA.1 infection induced antibodies

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

Co-circulation of adenovirus 40/41 and SARS-CoV-2 and emergence of hepatitis cases in children

Study investigates SARS-CoV-2 escape from nirmatrelvir

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

Targeting fatty acid metabolism holds promise for Parkinson's disease

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Longitudinal kinetics of the serological response in COVID-19 recovered patients over a period of 14 months

Researchers develop new chemical-only process for creating customized mRNA vaccines

A new coronavirus found in Swedish bank voles

Gastrointestinal complications caused by SARS-CoV-2

USC scientists receive more than $16 million to study the role of blood vessel dysfunction in Alzheimer’s disease

De novo-designed mini-protein against SARS-CoV-2

Omicron lineage spike proteins use ACE2 receptors more efficiently

Drug combination yields highest response and longest survival rates for patients with pancreatic NETs

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Link between COVID-19 severity and microbiome of saliva and nasopharynx

Safety and efficacy of SCB-2019 COVID vaccine candidate as a ChAdOx1-S booster

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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