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Loss of tumor protein p53 helps cancer cells grow in hostile environment

Researchers have discovered a novel consequence of loss of the tumor protein p53 that promotes cancer development, according to new findings in eLife.

17 Oct 2018

FDA grants Rare Pediatric Disease Designation for Immusoft’s Iduronicrin genleukocel-T

Immusoft Corporation, a Seattle-Wash.-based cell therapy company, announced today that the U.S. Food and Drug Administration (FDA) has granted it Rare Pediatric Disease Designation (RPDD) for Iduronicrin genleukocel-T, Immusoft's Sleeping Beauty transposon-engineered autologous plasmablasts for the expression and delivery of alpha-L-iduronidase (IDUA) to treat Mucopolysaccharidosis type I (MPS I).

17 Oct 2018

Researchers demonstrate epigenetic memory transmission via sperm

A new study suggests that if the epigenetics of sperm chromosomes are altered by the environment a father experiences, then this could affect offspring’s health.

17 Oct 2018

Women not warned about cancer associated with breast implants

Breast surgeons across the UK must ensure women are aware of BIA-ALCL, a non-Hodgkin’s lymphoma (a rare form of cancer) that is associated with implants; and more responsibility must be taken to diagnose and report cases, surgeons attending the 2018 London Breast Meeting have warned.

17 Oct 2018

Beckman Coulter Life Sciences announces new research-focused website

For a quarter century, the Beckman Coulter name has been important to clinicians and researchers worldwide.

From Beckman Coulter Life Sciences - Flow Cytometry 17 Oct 2018

Novel method uses just a drop of blood to monitor effect of lung cancer therapy

Dr Tasuku Honjo won the 2018 Nobel Prize in physiology or medicine for discovering the immune T-cell protein PD-1. This discovery led to a set of anti-cancer medications called checkpoint inhibitors, one of the first of which was nivolumab (Opdivo).

17 Oct 2018

Researchers to develop new stem cell-based strategies for treating vision disorders

A team from the University of Pennsylvania, Children's Hospital of Philadelphia, and University of Wisconsin--Madison are launching a project to develop new strategies for treating vision disorders using cells implanted in the retina.

17 Oct 2018

Down syndrome may hold important clues to onset of Alzheimer's disease

At first glance, Down syndrome and Alzheimer's disease, two severe brain abnormalities, may seem to have little in common. Down syndrome is a hereditary disease, the source of which has long been recognized--a triplication of chromosome 21.

17 Oct 2018

Researchers find opportunity to control salt-sensitive hypertension without exercising

Couch potatoes rejoice -- there might be a way to get the blood pressure lowering benefits of exercise in pill form.

16 Oct 2018

Study to explore bioethics of brain organoids

Research scientists around the world are now able to investigate the structural, cellular, and developmental intricacies of the human brain using bioengineered stem cell-based models called organoids.

16 Oct 2018

Study of Nigerian breast cancer patients reveals prevalence of aggressive molecular features

A study comparing DNA and RNA data from Nigerian breast cancer patients to patients in a United States database found that certain aggressive molecular features were far more prevalent in tumors from Nigerian women than in black or white American women.

16 Oct 2018

New findings reveal potential cellular players in tumor microenvironment

New findings presented today by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients - those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy.

16 Oct 2018

Fish oil based diets may suppress growth and spread of breast cancer cells

Omega-3 fatty acids, such as those typically contained in fish oil, may suppress the growth and spread of breast cancer cells in mice.

16 Oct 2018

Simple, inexpensive test quickly detects antibiotic-resistant 'superbugs'

When you get sick, you want the right treatment fast. But certain infectious microbes are experts at evading the very anti-bacterial drugs designed to fight them.

16 Oct 2018

Study uncovers important role of PRMT1 in dilated cardiomyopathy

In a study published in iScience, Professor Akiyoshi Fukamizu of the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (University of Tsukuba, JAPAN) and the research group reported a new work on discovery of the important role of PRMT1 in dilated cardiomyopathy.

16 Oct 2018

Zebrafish study uncovers molecular 'brake' that helps control eye lens development

How different cells in a multicellular organism acquire their identities remains a fundamental mystery of development. In the eye, for example, the lens contains two cell types - lens epithelial cells and lens fiber cells -- the first of which differentiates into the second as an animal matures.

16 Oct 2018

Rice University chemist wins big award to study small surfaces

It's one thing to start a chemical reaction and get a result, but it's quite another thing to watch it in progress. Rice University chemist Matt Jones wants to see it happen.

16 Oct 2018

Birth mode may have acute effects on neurodevelopment, study suggests

Cesarean-born mice show altered patterns of cell death across the brain, exhibiting greater nerve cell death than vaginally delivered mice in at least one brain area, a finding by Georgia State University researchers that suggests birth mode may have acute effects on human neurodevelopment that may lead to long-lasting changes in the brain and behavior.

16 Oct 2018

Non-invasive brain stimulation sheds light on neurobiology underlying implicit bias

BIDMC Research Briefs showcase groundbreaking scientific advances that are transforming medical care.

16 Oct 2018

Researchers examine SSRI use during pregnancy and major gestational malformations

A comprehensive new review article presents the most current understanding of the role selective serotonin reuptake inhibitors play in increased risk of multiple diverse gestational malformations and takes aim at the ongoing debate over whether SSRIs as a drug class can cause these malformations.

16 Oct 2018