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Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

8 Oct 2018

New genome editing tool used to heal genetic disease

Parents of newborns may be familiar with the metabolic disorder phenylketonuria: in Switzerland, all newborn babies are screened for this genetic disease.

8 Oct 2018

Beyond BRCA: Epigenetic Silencing in Breast Cancer

An interview with Professor William Newman, discussing his recent discovery in the field of breast cancer research, and the options that this will provide for women who have a family history of breast cancer but test negative for BRCA1/2 mutations.

8 Oct 2018

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Verastem, Inc., focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced that the National Comprehensive Cancer Network added COPIKTRA (duvelisib) capsules to the Clinical Practice Guidelines in Oncology (NCCN Guidelines) for follicular lymphoma.

8 Oct 2018

Researchers show possibility to restore insulin cell function in type 2 diabetes

By blocking a protein, VDAC1, in the insulin-producing beta cells, it is possible to restore their normal function in case of type 2 diabetes. In preclinical experiments, the researchers behind a new study have also shown that it is possible to prevent the development of the disease.

8 Oct 2018

DFG publishes new position paper on synthetic biology

Scientific developments in the field of synthetic biology have often given rise to public debate on the possible need for additional regulation. In response, the Permanent Senate Commission on Genetic Research of the Deutsche Forschungsgemeinschaft has published a position paper on synthetic biology, in which it describes key scientific advancements in the field within the context of current public discourse.

8 Oct 2018

The feds’ termination of a tiny contract inflames bitter fight over fetal tissue

Federal health officials announced late last month they had terminated their contract with a company that supplies human fetal tissue for medical research and were checking that similar contracts, as well as studies conducted with that tissue, comply with federal law.

8 Oct 2018

Joint research team discovers potential new treatment for severe malaria

Scientists from Massachusetts Institute of Technology, Singapore-MIT Alliance for Research and Technology and Nanyang Technological University, Singapore have discovered a potential treatment that could be effective against severe malaria and even drug-resistant malaria.

8 Oct 2018

Damage to small nerves shown to be cause of chronic pain following knee surgeries

Patients frequently experience severe chronic pain following knee operations. Although the pain is thought to be due to damage to small nerves, it was hitherto impossible to demonstrate this by imaging.

8 Oct 2018

New blood test may detect early-stage lung cancer when surgical intervention is not possible

Non-small-cell lung carcinoma is often fatal because most cases are not diagnosed until they are so advanced that surgical intervention is no longer possible. To improve outcomes researchers are developing a blood test to detect lung cancer earlier in the disease.

8 Oct 2018

Nanopore technology combined with DNA computing to catch early biomarkers for small cell lung cancer

Small Cell Lung Cancer is very aggressive, since the cancer cells not only quickly grow but also easily spread to entire body. Often SCLC can be diagnosed using several common tests unfortunately after spread of cancer cells, resulting in poor survival.

7 Oct 2018

Researchers streamline design of lab-on-a-chip devices to observe their inner workings

Microfluidic devices can take standard medical lab procedures and condenses each down to a microchip that can balance on top of a water bottle lid.

6 Oct 2018

UTMB researchers develop less expensive way to produce vaccines

Researchers at The University of Texas Medical Branch at Galveston have developed less expensive way to produce vaccines that cuts the costs of vaccine production and storage by up to 80 percent without decreasing safety or effectiveness.

6 Oct 2018

Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

Inflammation is currently a well-documented component of atheroslcerosis pathogenesis, which plays a role at each stage of the disease development.

6 Oct 2018

Research reveals new details of HIV life cycle

Research by a multi-institutional team, including two members from the University of Delaware, has revealed new details about the HIV virus capsid structure and how it develops.

5 Oct 2018

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

A team of Medical University of South Carolina Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defens to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development.

5 Oct 2018

Researchers discover previously unknown function of key component in the immune system

The complement proteins that circulate in our blood are an important part of our immune system. They help identify bacteria, viruses and other harmful organisms, making it easier for our white blood cells to find and neutralize dangerous microbes.

5 Oct 2018

New method for studying the cell nucleus could improve disease detection

Researchers at New York University have found a way to measure the physical properties of the nucleus and its constituents in live human cells.

5 Oct 2018

RNA sequencing method uncovers new insights into biological events in heart disease

Scientists using a powerful new technology that sequences RNA in 20,000 individual cell nuclei have uncovered new insights into biological events in heart disease.

5 Oct 2018

Scripps Research scientists discover role of immune system double agent

Scientists at Scripps Research have discovered the role of an immune system double agent. This molecule, called USP18, can help curtail immune responses, but it can also open the door to bacterial infections, such as harmful listeria and staph infections.

5 Oct 2018

B Cell News and Research

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

New genome editing tool used to heal genetic disease

Beyond BRCA: Epigenetic Silencing in Breast Cancer

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Researchers show possibility to restore insulin cell function in type 2 diabetes

DFG publishes new position paper on synthetic biology

The feds’ termination of a tiny contract inflames bitter fight over fetal tissue

Joint research team discovers potential new treatment for severe malaria

Damage to small nerves shown to be cause of chronic pain following knee surgeries

New blood test may detect early-stage lung cancer when surgical intervention is not possible

Nanopore technology combined with DNA computing to catch early biomarkers for small cell lung cancer

Researchers streamline design of lab-on-a-chip devices to observe their inner workings

UTMB researchers develop less expensive way to produce vaccines

Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

Research reveals new details of HIV life cycle

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Researchers discover previously unknown function of key component in the immune system

New method for studying the cell nucleus could improve disease detection

RNA sequencing method uncovers new insights into biological events in heart disease

Scripps Research scientists discover role of immune system double agent

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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