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Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.

6 Jun 2022

New method to combat malaria turns the disease against itself

A new method to combat malaria which sees the disease turn against itself could offer an effective treatment for the hundreds of millions of people infected globally each year, as the efficacy of current antimalarial drugs weakens.

3 Jun 2022

Truncated tau protein may be a means for better diagnosis and treatment of Alzheimer's disease

In a new study of Alzheimer's disease, researchers at UC San Francisco have discovered that a relatively unstudied form of the tau protein associated with neurodegeneration may be a means for better diagnosis and treatment of the disease.

2 Jun 2022

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

Researchers looked into the role played by the accessory proteins using synthetic genomics assembly technology

2 Jun 2022

ASU study explores components of the immune system

Unless you are an identical twin, you probably aren't often mistaken for someone else. Likewise, our own sense of self as distinct from all other humans is deeply ingrained since early childhood.

2 Jun 2022

Collaborative effort uncovers a new type of triterpenes

A remarkable discovery and collaborative effort have revealed a new type of triterpenes, a group of organic compounds which are an important source of many medicines.

1 Jun 2022

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests.

1 Jun 2022

Membrane lipid stops stress reactions and inhibits cell death

Programmed cell death is an important tool that an organism uses to keep itself healthy. When a cell does not function as it should, various stress reactions are activated. The goal of these reactions is to restore the original cell function.

1 Jun 2022

Inverse relationship identified between SARS-CoV-2 and influenza infections

A new study identifies the potential correlations that exist between SARS-CoV-2 and influenza infections.

1 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

Scientists develop new way to attack synovial sarcoma using an investigational drug

Researchers at Washington University School of Medicine in St. Louis have developed a way to attack synovial sarcoma - a rare tumor of soft tissues, such as ligaments and muscles - using an investigational drug that triggers cell death.

31 May 2022

The effect of CMV serostatus on humoral and cellular measures of vaccine responses after 2 and 3 doses of SARS-CoV-2 mRNA vaccines in older adults

Researchers evaluated the impact of CMV seropositivity on humoral and cellular immune responses generated after double and/or triple mRNA vaccination against SARS-CoV-2 among the elderly.

31 May 2022

The pineapple-derived jacalin-related lectin as a potential anti-SARS-CoV-2 agent

Scientists demonstrated that the pineapple-derived jacalin-related lectin (AcmJRL/AnLec) could be an anti-SARS-CoV-2 agent.

31 May 2022

The immunogenicity and safety of the adjuvanted recombinant protein vaccine Sanofi/GSK-D614 or -B.1.351 administered as a heterologous booster dose

Researchers assessed the safety and immunogenicity of SARS-CoV-2 booster vaccines.

31 May 2022

Evaluating tixagevimab plus cilgavimab against SARS-CoV-2

Researchers assessed the neutralizing activity against SARS-CoV-2 Omicron variant after tixagevimab plus cilgavimab (T+C) administration.

30 May 2022

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Researchers identified 10-40, a human monoclonal antibody with potent neutralizing activity against SARS-CoV, SARS-CoV-2, and related sarbecoviruses.

30 May 2022

Enzyme News and Research

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

New method to combat malaria turns the disease against itself

Truncated tau protein may be a means for better diagnosis and treatment of Alzheimer's disease

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

ASU study explores components of the immune system

Collaborative effort uncovers a new type of triterpenes

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Membrane lipid stops stress reactions and inhibits cell death

Inverse relationship identified between SARS-CoV-2 and influenza infections

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Scientists develop new way to attack synovial sarcoma using an investigational drug

The effect of CMV serostatus on humoral and cellular measures of vaccine responses after 2 and 3 doses of SARS-CoV-2 mRNA vaccines in older adults

The pineapple-derived jacalin-related lectin as a potential anti-SARS-CoV-2 agent

The immunogenicity and safety of the adjuvanted recombinant protein vaccine Sanofi/GSK-D614 or -B.1.351 administered as a heterologous booster dose

Evaluating tixagevimab plus cilgavimab against SARS-CoV-2

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Exploring virological profiles of recently emerged SARS-CoV-2 Omicron variants

Continuous evolution of SARS-CoV-2 Omicron variant yielding immune evasive subvariants

Hemodialysis patients obtain a robust humoral response from a third dose of the BNT162b2 vaccine, study finds

Study finds long-term exposure to common air pollutants is associated with COVID-19 severity

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo