Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Researchers develop new microsystem for testing drugs to treat epilepsy, MG and cystic fibrosis

Researchers from the University of Southampton, in collaboration with researchers at the University of Quebec at Montreal, have developed a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.

26 Nov 2013

Dysregulation of epigenetic marks may play role in chronic kidney disease, shows study

The research of physician-scientist Katalin Susztak, MD, PhD, associate professor of Medicine in the Renal Electrolyte and Hypertension Division, at the Perelman School of Medicine, University of Pennsylvania, strives to understand the molecular roots and genetic predisposition of chronic kidney disease.

26 Nov 2013

Researchers to discuss effects of alcohol on immune system at AIRIG meeting

On Nov. 22, leading alcohol researchers from the United States and Europe will present the latest findings on how alcohol impairs the immune system.

22 Nov 2013

Antibiotic resistance holds stable in U.S. children's hospitals

Two studies published in the December issue of Infection Control and Hospital Epidemiology show antibiotic resistance patterns for children have held stable over a seven-year period and surgical patients in U.S. children's hospitals account for 43 percent of all antibiotic use in children's hospitals, presenting an opportunity for targeted intervention.

21 Nov 2013

FibroGen presents China-based Phase 2 study data of roxadustat for treatment of CKD patients

FibroGen, Inc. (FibroGen), today announced that data from a China-based Phase 2 study of roxadustat (FG-4592), a first-in-class oral compound in late stage development for the treatment of anemia associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD), were presented in an oral session at the 2013 American Society of Nephrology (ASN) Kidney Week in Atlanta, Georgia.

13 Nov 2013

Promethera Biosciences completes patient enrolment for first clinical trial of HepaStem

Promethera Biosciences, a Belgian biotechnology company developing Promethera HepaStem, a cell-based therapy for the treatment of liver-based metabolic diseases including Crigler-Najjar Syndrome and Urea Cycle Disorders, announces today the completion of patient enrolment for its first clinical trial.

12 Nov 2013

LUHS offers highly accurate prenatal test to determine chromosomal abnormalities in fetus

Loyola University Health System (LUHS) now offers chorionic villus sampling (CVS), a highly accurate prenatal test for chromosomal abnormalities in the fetus. Loyola is one of the few centers in the Chicago area to offer CVS.

12 Nov 2013

Risk of dangerous bloodstream infections can be reduced in newborns with central venous catheters

A new study led by Johns Hopkins Children's Center investigators shows that clinicians can reduce the risk of dangerous bloodstream infections in newborns with central venous catheters by ending use of the device as soon as possible, rather than waiting for signs of infection.

11 Nov 2013

Genovate, ScinoPharm to jointly develop new-generation oral Hepatitis B drug Livepro

Genovate Biotechnology Co. Ltd. and ScinoPharm Taiwan Ltd. announced today that they have jointly developed the highly potent oral generic drug Livepro (Entecavir), representing a new generation of drugs for the treatment of Hepatitis B. It is expected to be commercially available by the end of the year in Taiwan, accounting for more than NT$2 billion (US$70 million) worth of market opportunity.

11 Nov 2013

Findings demonstrate potential new therapeutic approach to treat fibrotic diseases

A team of scientists that includes Saint Louis University researchers has identified a new way to intervene in the molecular and cellular cascade that causes fibrosis - a condition where the body's natural process of forming scars for wound healing goes into overdrive and causes diseases.

11 Nov 2013

Tissue scarring may help develop new treatments for patients with damaged organs

Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar.

10 Nov 2013

Inhibition of heart protein reduces damage from heart attack, say researchers

The stop and start of blood flow to the heart during and after a heart attack causes severe damage to heart cells, reducing their capacity to function and potentially causing their death.

7 Nov 2013

Genkyotex announces initiation of GKT137831 Phase II study in patients with diabetic nephropathy

Genkyotex, the leading developer of selective NOX enzyme inhibitors, announced today the initiation of a multinational Phase II clinical study of GKT137831 in patients with diabetic nephropathy.

5 Nov 2013

Pivotal Phase III STARTVerso data shows efficacy of faldaprevir in genotype-1 infected HCV patients

Boehringer Ingelheim today announced new data from its Phase III clinical trial programme, STARTVerso, which evaluates faldaprevir in combination with pegylated interferon and ribavirin (PegIFN/RBV).

5 Nov 2013

Polyphor, Roche agree to develop and commercialize antibiotic for bacterial infections

Polyphor Ltd, a privately held pharmaceutical company, and Roche announced today that they have entered into an exclusive worldwide license agreement to develop and commercialize Polyphor's investigational macrocycle antibiotic, POL7080, for patients suffering from bacterial infections caused by Pseudomonas aeruginosa.

4 Nov 2013

Solution for enzyme-based diagnostic testing in remote locations to be exhibited by Sherwood Scientific at MEDICA 2013

Sherwood Scientific Ltd will exhibit the CHROMA Model 260uv Programmable Colorimeter for the first time at MEDICA 2013 (20 - 23 November 2013, Düsseldorf Fairgrounds, Germany). The instrument allows users to conduct enzyme-based tests in challenging and remote locations without access to a laboratory. Also on display at MEDICA will be Sherwood Scientific’s magnetic susceptibility balance and the model 926S Chloride analyser, both valuable and established tools in clinical applications.

1 Nov 2013

Research provides better understanding of molecular interactions related to cystic fibrosis

Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis.

30 Oct 2013

Queen's University is lead partner in £6M global research program to develop new ways to treat CF

Queen's University Belfast is a lead partner in a new -6 million (euro) global research programme to develop new ways to treat Cystic Fibrosis.

30 Oct 2013

Protective effect of estrogen in women with NASH against development of severe fibrosis

New research suggests that estrogen protects women with nonalcoholic steatohepatitis (NASH) from severe liver fibrosis. According to the study published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, men are at higher risk of more severe fibrosis compared to women prior to menopause, but liver fibrosis severity is similar in men and post-menopausal women.

30 Oct 2013

Review on barriers to medical adherence among chronically ill adolescents

Teenagers with chronic illnesses face special barriers that may interfere with how well they adhere to their medical treatment, according to a new review in the Journal of Adolescent Health.

29 Oct 2013

Fibrosis News and Research

Further Reading

Researchers develop new microsystem for testing drugs to treat epilepsy, MG and cystic fibrosis

Dysregulation of epigenetic marks may play role in chronic kidney disease, shows study

Researchers to discuss effects of alcohol on immune system at AIRIG meeting

Antibiotic resistance holds stable in U.S. children's hospitals

FibroGen presents China-based Phase 2 study data of roxadustat for treatment of CKD patients

Promethera Biosciences completes patient enrolment for first clinical trial of HepaStem

LUHS offers highly accurate prenatal test to determine chromosomal abnormalities in fetus

Risk of dangerous bloodstream infections can be reduced in newborns with central venous catheters

Genovate, ScinoPharm to jointly develop new-generation oral Hepatitis B drug Livepro

Findings demonstrate potential new therapeutic approach to treat fibrotic diseases

Tissue scarring may help develop new treatments for patients with damaged organs

Inhibition of heart protein reduces damage from heart attack, say researchers

Genkyotex announces initiation of GKT137831 Phase II study in patients with diabetic nephropathy

Pivotal Phase III STARTVerso data shows efficacy of faldaprevir in genotype-1 infected HCV patients

Polyphor, Roche agree to develop and commercialize antibiotic for bacterial infections

Solution for enzyme-based diagnostic testing in remote locations to be exhibited by Sherwood Scientific at MEDICA 2013

Research provides better understanding of molecular interactions related to cystic fibrosis

Queen's University is lead partner in £6M global research program to develop new ways to treat CF

Protective effect of estrogen in women with NASH against development of severe fibrosis

Review on barriers to medical adherence among chronically ill adolescents

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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