immunity News and Research

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Prophylactic administration of SARS-CoV-2 specific immunoglobulin Y generated in chicken eggs displays protective effects in infected mice

A new study characterized and tested the antibody activity of SARS-CoV-2-specific immunoglobulin Y (IgY) derived from the eggs laid by chickens immunized with recombinant SARS-CoV-2 receptor binding domain (RBD) protein.

21 Sep 2022

Covid still kills, but the demographics of its victims are shifting

As California settles into a third year of pandemic, covid-19 continues to pose a serious threat of death. But the number of people dying — and the demographics of those falling victim — has shifted notably from the first two years.

21 Sep 2022

Researchers report development of a self-assembled trimeric RBD subunit vaccine able to prevent SARS-CoV-2 infection

The present study reported the development of a new self-assembled trimeric RBD subunit vaccine that could effectively prevent infection from SARS-CoV-2 variants, including the currently dominantly circulating Omicron variant.

21 Sep 2022

Study reveals improved immunogenicity and safety of bivalent Omicron-containing mRNA-1273.214 candidate booster vaccine

In a new study, a team of researchers assessed the safety and efficacy of a bivalent candidate vaccine containing spike messenger ribonucleic acids of the ancestral Wuhan-Hu-1 strain and the Omicron B.1.1.529 [BA.1] variant of SARS-CoV-2.

21 Sep 2022

Study reveals increased immunity evasion by Omicron BA.2.75.2

In a recent study posted to the bioRxiv* preprint server, researchers from ETH Zurich, Imperial College London, and Karolinska Institutet identified increased resistance to antibody-mediated neutralization by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineage BA.2.75.2.

21 Sep 2022

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM).

20 Sep 2022

Vaccination-induced responses for Omicron subvariant neutralization

Researchers summarized existing data on SARS-CoV-2 Omicron variant’s sub-variant (BA.1, BA.1.1, BA.2, BA.2.12.1, BA.3, and BA.4/5) neutralization. They also performed a comparative assessment of cross-neutralizing responses of Omicron subvariants in comparison to the Wuhan-Hu-1 strain (prototype) antigen.

20 Sep 2022

Link between type 2 diabetes and UTIs explained

Lower immunity and recurring infections are common in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden now show that the immune system of people with diabetes has lower levels of the antimicrobial peptide psoriasin, which compromises the urinary bladder's cell barrier, increasing the risk of urinary tract infection.

20 Sep 2022

Healthcare systems seem may be ill-equipped to handle high co-circulation of influenza and SARS-CoV-2 in the coming year

In a new study, researchers conducted a community-based prospective cohort study in Managua, Nicaragua, before the winter season when influenza A (H3N2) cases surge in the Northern Hemisphere.

20 Sep 2022

Neutralizing antibody responses, breakthrough SARS-CoV-2 infections, and symptoms after booster BNT162b2 COVID-19 vaccinations

A new study evaluated neutralizing antibody (nAb) responses against the SARS-CoV-2 Omicron variant induced by booster vaccination with Pfizer-BioNTech’s BNT162b2 messenger ribonucleic acid vaccine.

20 Sep 2022

Monkeypox infection in a smallpox-vaccinated patient

In a recent study published in the Emerging Infectious Diseases journal, researchers at Madigan Army Medical Center assessed the characteristics of monkeypox infection in a patient vaccinated against smallpox.

20 Sep 2022

In Denmark, Omicron reinfections reveal ineffective post-COVID-19 immunity

In a recent study posted to the medRxiv* preprint server, researchers investigated variant-wise SARS-CoV-2 reinfection cases in Denmark.

20 Sep 2022

Molecular engineered low-cost highly effective RBD-based COVID vaccine

In a recent study posted to the bioRxiv* preprint server, an international team of researchers developed a second-generation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) antigen (RBD-J6) by molecular engineering with two additional amino acid (aa) substitutions (S383D and L518D mutations) in a hydrophobic cryptic RBD core epitope to enhance stability and expression against SARS-CoV-2 variants of concern (VOCs).

19 Sep 2022

Environmental surveillance detects poliovirus type 2 outbreaks in Israel

The wastewater environmental surveillance conducted in Jerusalem, Israel, has detected an increasing population of poliovirus type 2. Furthermore, these viral isolates are associated with vaccine-derived viral strains.

19 Sep 2022

Study provides an update on depression prevalence among the U.S. population

Increases in depression without commensurate increases in treatment are widespread, reports a study conducted at Columbia University Mailman School of Public Health and City University of New York.

19 Sep 2022

United States joins 30 other countries with circulating vaccine-derived poliovirus

CDC today announced that polioviruses found in New York, both from the case of paralytic polio in an unvaccinated adult in Rockland County and in several wastewater samples from communities near the patient's residence, meet the World Health Organization (WHO)'s criteria for circulating vaccine-derived poliovirus (cVDPV) – meaning that poliovirus continues to be transmitted in Rockland County, NY, and surrounding areas.

19 Sep 2022

Comparative hospitalization and mortality risk in the US population during the Omicron and Delta periods

Researchers compared in-hospital mortality across COVID-19 pandemic periods.

19 Sep 2022

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the role of two cytokines, interferon-gamma (IFN-γ) and interleukin-10 (IL-10), in regulating immune cell responses and inflammation early during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in rhesus macaques.

18 Sep 2022

An improved COVID-19 vaccine shows promise against Omicron in experimental models

In a recent study published in the journal Science Translational Medicine, researchers in the United States designed a bivalent coronavirus disease 2019 (COVID-19) vaccine on the messenger ribonucleic acid (mRNA) platform.

18 Sep 2022

Mortality risk higher among children with primary immunodeficiency diseases infected with SARS-CoV-2

Children with certain immunodeficiency diseases carry mutations in genes that regulate the body's immune system against viral infections and they have a higher mortality rate due to COVID-19.

16 Sep 2022

immunity News and Research

Prophylactic administration of SARS-CoV-2 specific immunoglobulin Y generated in chicken eggs displays protective effects in infected mice

Covid still kills, but the demographics of its victims are shifting

Researchers report development of a self-assembled trimeric RBD subunit vaccine able to prevent SARS-CoV-2 infection

Study reveals improved immunogenicity and safety of bivalent Omicron-containing mRNA-1273.214 candidate booster vaccine

Study reveals increased immunity evasion by Omicron BA.2.75.2

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

Vaccination-induced responses for Omicron subvariant neutralization

Link between type 2 diabetes and UTIs explained

Healthcare systems seem may be ill-equipped to handle high co-circulation of influenza and SARS-CoV-2 in the coming year

Neutralizing antibody responses, breakthrough SARS-CoV-2 infections, and symptoms after booster BNT162b2 COVID-19 vaccinations

Monkeypox infection in a smallpox-vaccinated patient

In Denmark, Omicron reinfections reveal ineffective post-COVID-19 immunity

Molecular engineered low-cost highly effective RBD-based COVID vaccine

Environmental surveillance detects poliovirus type 2 outbreaks in Israel

Study provides an update on depression prevalence among the U.S. population

United States joins 30 other countries with circulating vaccine-derived poliovirus

Comparative hospitalization and mortality risk in the US population during the Omicron and Delta periods

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

An improved COVID-19 vaccine shows promise against Omicron in experimental models

Mortality risk higher among children with primary immunodeficiency diseases infected with SARS-CoV-2

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