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A tiny fish could end painful metabolic and genetic bone diseases

In a study published recently in Communications Biology, researchers led by Kanazawa University explain how a tiny fish could help end painful metabolic and genetic bone diseases.

15 Jul 2020

Strong evidence several FDA approved drugs block SARS-CoV-2 in relevant cell-lines and human organoids

Now, a new study describes how compounds that restore the normal transcriptional conditions following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be used to reduce viral load without neutralizing the virus entry into the host cell.

15 Jul 2020

Absolute Antibody and University of Zurich partner to offer novel SARS-CoV-2 sybodies

Absolute Antibody Ltd., an industry-leading provider of recombinant antibody products and services, today announced a partnership with University of Zurich to offer synthetic nanobodies against the receptor binding domain (RBD) of SARS-CoV-2, the coronavirus that causes COVID-19.

From Absolute Antibody Ltd 14 Jul 2020

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Researchers have developed a new pair of agents that show exceptional effectiveness for precision diagnosis and treatment of prostate cancer in preclinical studies.

13 Jul 2020

Bird poop may harbor abundant antibiotic resistance genes

Bird poop may pose more health risks than people realize, according to Rice University environmental engineers who study antibiotic resistance.

13 Jul 2020

Study sheds new light on neurobiological processes that control drug-related adaptations

The lab of Jeremy Day, Ph.D., at the University of Alabama at Birmingham, has used single-nucleus RNA sequencing approaches to compare transcriptional responses to acute cocaine in 16 unique cell populations from a portion of the brain called the nucleus accumbens, or NAc.

10 Jul 2020

Expansion stress promotes aggressive tumor cell growth in breast cancer

Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.

9 Jul 2020

Research shows how SARS-CoV-2 alters translation

Now, a new study published on the preprint server bioRxiv in July 2020 shows that the 5’ end of the RNA molecule is capable of inhibiting the binding of mRNA to the ribosomal 40S subunit, thus preventing translation.

9 Jul 2020

New technology can rapidly disrupt existing biofilms that account for chronic diseases

Chronic and recurrent bacterial diseases are treatment-resistant due to the ability of the pathogens to establish biofilms, which act as fortresses built of extracellular DNA and proteins to protect populations of the bacteria.

8 Jul 2020

Researchers develop bioprinted skin model of cutaneous squamous cell carcinoma

The cover for issue 27 of Oncotarget features "Bimodal imaging examples of control and treated tumors (red) before and after the treatment period," by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue.

7 Jul 2020

Researchers isolate protective antibodies for rare, polio-like disease in children

Researchers at Vanderbilt University Medical Center, Purdue University and the University of Wisconsin-Madison have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.

3 Jul 2020

Newer form of SARS-CoV-2 coronavirus dominates global infections

Research out today in the journal Cell shows that a specific change in the SARS-CoV-2 coronavirus virus genome, previously associated with increased viral transmission and the spread of COVID-19, is more infectious in cell culture.

2 Jul 2020

New technology can increase the quality of stem cells used in regenerative medicine

Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a variety of different cell types, can be applied in regenerative medicine for diseases such as muscular and nervous system disorders, among others.

2 Jul 2020

Structure of the full SARS-CoV-2 RNA genome in infected cells

The current COVID-19 pandemic caused by a single-stranded RNA virus, thought to have jumped across species barriers to infect humans, has spread rapidly across the globe infecting over 10 million individuals. The virus, now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causative agent of COVID-19 disease. COVID-19 disease is a respiratory illness where symptoms can range from very mild to severe and include fever, coughing, a sore throat, and shortness of breath.

2 Jul 2020

Repurposed drug for acute lung injury in COVID-19

Now, a new study addresses the possible use of an FDA-approved monoclonal antibody, called fostamatinib, a spleen tyrosine kinase inhibitor (SYK), to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respiratory distress syndrome (ARDS). People who have severe COVID-19 disease may develop ARDS.

2 Jul 2020

Researchers discover a protein that protects B cells from stress-induced cell death

Whenever a germ gets into the human body, the immune system usually responds immediately to fight off the enemy attacker. One of our defense system's most important strategies involves B lymphocytes, also known as B cells, which produce antibodies that target and neutralize pathogens.

1 Jul 2020

in vivo News and Research

A tiny fish could end painful metabolic and genetic bone diseases

Strong evidence several FDA approved drugs block SARS-CoV-2 in relevant cell-lines and human organoids

Absolute Antibody and University of Zurich partner to offer novel SARS-CoV-2 sybodies

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Bird poop may harbor abundant antibiotic resistance genes

Study sheds new light on neurobiological processes that control drug-related adaptations

Expansion stress promotes aggressive tumor cell growth in breast cancer

Research shows how SARS-CoV-2 alters translation

New technology can rapidly disrupt existing biofilms that account for chronic diseases

Researchers develop bioprinted skin model of cutaneous squamous cell carcinoma

Researchers isolate protective antibodies for rare, polio-like disease in children

Newer form of SARS-CoV-2 coronavirus dominates global infections

New technology can increase the quality of stem cells used in regenerative medicine

Structure of the full SARS-CoV-2 RNA genome in infected cells

Repurposed drug for acute lung injury in COVID-19

Researchers discover a protein that protects B cells from stress-induced cell death

Researchers develop biomedical device for use in regenerative medicine

New polymeric heart valve could be a life-saver

A semi-empirical model to reproduce the brain states from wakefulness to deep sleep

Enhanced photoacoustic imaging improves cancer staging

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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