Animal Model News and Research

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Impaired intestinal metabolic function plays a critical role in the development of cardiovascular disease

Nutritional scientists at the University of Alberta are the first to establish a connection between high insulin levels and dysfunction of intestinal lipid metabolism in an animal model.

25 Apr 2007

Muscle restoration in an animal model of Duchenne muscular dystrophy

Using a new type of drug that targets a specific genetic defect, researchers at the University of Pennsylvania School of Medicine, along with colleagues at PTC Therapeutics Inc. and the University of Massachusetts Medical School, have for the first time demonstrated restoration of muscle function in a mouse model of Duchenne's muscular dystrophy (DMD).

24 Apr 2007

M. D. Anderson wins $8.3-million to research environmental causes of major diseases

An $8.3-million federal grant to The University of Texas M. D. Anderson Cancer Center Science Park - Research Division addresses the complex interplay between such varied factors as genetics, diet, and environmental exposure to toxins that cause cancer, asthma, diabetes, cardiovascular and other diseases.

21 Apr 2007

Green tea may help protect against Sjogren's syndrome

They found significantly less salivary gland damage in a group treated with green tea extract, suggesting a reduction of the Sjogren's symptom commonly referred to as dry mouth. Dry mouth can also be caused by certain drugs, radiation and other diseases.

20 Apr 2007

New approach to cystic fibrosis treatment

Researchers at the University of Pennsylvania School of Medicine have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis patients.

19 Apr 2007

Novel method to expand the number of immune system "natural killer" cells from blood cells outside the body

Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have devised a novel method to expand the number of immune system "natural killer (NK)" cells from blood cells outside the body.

19 Apr 2007

New discoveries about stem cells in leukemia, breast and colon cancer

Recent discoveries about the role of stem cells in cancer have altered the landscape of cancer research. With each new study, scientists are learning more about cancer-initiating properties of stem cells at organ sites and throughout the body.

19 Apr 2007

Animal model for binge eating disorder

University of Alabama at Birmingham (UAB) psychologists have developed an animal model for the binge eating disorder, which affects an estimated one in 20 Americans.

18 Apr 2007

Martek's DHA algal oil reduces brain lesions in Alzheimer's animal model

Martek's proprietary DHA algal oil may slow the development of two brain lesions that are hallmarks of Alzheimer's disease, according to a study featured in the April 18 issue of the Journal of Neuroscience.

18 Apr 2007

A candidate neural circuit for stress-induced analgesia

Recent statistics indicate that one in five people worldwide suffer from moderate to severe chronic pain and that one in three are unable or less able to maintain an independent lifestyle due to their pain.

17 Apr 2007

High levels of antibodies - low levels of cancer!

Active immunisation can stimulate the body to produce highly efficient IgE antibodies that attack tumours.

17 Apr 2007

Mapping rhesus macaque genome helps illuminate what makes us human

Researchers have sequenced the genome of the relatively ancient rhesus macaque ( Macaca mulatta ), providing perspective into how humans are genetically different from our primate relatives.

15 Apr 2007

Analysis of Rhesus monkey genome provides new clues to primate biology

An international consortium of researchers has published the genome sequence of the rhesus macaque monkey and aligned it with the chimpanzee and human genomes.

12 Apr 2007

Protecting brains of premature infants - new approach needed

A study of how the brain of a premature infant responds to injury has found vulnerabilities similar to those in the mature brain but also identified at least one significant difference, according to neuroscientists and neonatologists at Washington University School of Medicine in St. Louis.

11 Apr 2007

Female stem cells work better

Female stem cells derived from muscle have a greater ability to regenerate skeletal muscle tissue than male cells, according to a study at Children's Hospital of Pittsburgh of UPMC.

10 Apr 2007

Modified bone marrow cells help recovery in an animal model of multiple sclerosis

These findings will need to be repeated in further animal models before the implications for human disease are clear; however, they open up an avenue of further research.

10 Apr 2007

New imaging technology with use of novel contrast agent may predict heart attack in waiting

A new imaging technology may hold the key to not only stopping heart attacks in their tracks but also preventing them for ever occurring.

10 Apr 2007

Cylindrical nanoparticles deliver drugs to tumors

Researchers at the University of Pennsylvania School of Medicine & School of Engineering and Applied Science have discovered a better way to deliver drugs to tumors.

7 Apr 2007

Researchers show blood-brain barrier damage could affect multiple sclerosis severity

Immunology researchers at the Kimmel Cancer Center at Jefferson studying a multiple sclerosis (MS)-like disease in mice have shown that the amount of "damage" to the central nervous system's protective blood-brain barrier, in essence, opening it, almost always correlates to the severity of the disease.

7 Apr 2007

TGF-beta found to be a major player in causing bronchopulmonary dysplasia

Researchers from Massachusetts General Hospital, in collaboration with scientists from the Genzyme Corporation, have identified a potential treatment for a chronic lung disease affecting premature infants.

4 Apr 2007