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Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

20 Jul 2020

Oxytocin can help treat cognitive disorders

Alzheimer’s disease progressively degrades a person’s memory and cognitive abilities, often resulting in dementia.

20 Jul 2020

SARS-CoV-2 protein effectively shuts down production of proteins in the host, study shows

A detailed study of a SARS-Cov-2 protein, Nsp1, with a central role in weakening the host anti-viral immune response shows that it effectively shuts down production ofproteins in the host.

17 Jul 2020

Groundbreaking technology could enhance therapeutic efficiency of nanomedicines

Researchers from the Moscow Institute of Physics and Technology and their colleagues from Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry and Prokhorov General Physics Institute of the Russian Academy of Sciences have developed a breakthrough technology to resolve a key problem that has prevented the introduction of novel drugs into clinical practice for decades.

17 Jul 2020

Study reveals antiviral effects of curcumin

Curcumin, a natural compound found in the spice turmeric, could help eliminate certain viruses, research has found.

17 Jul 2020

Blood vessels communicate with sensory neurons to regulate their proliferation

Researchers at Pompeu Fabra University have shown for the first time that blood vessels communicate with neurons in the peripheral nervous system, regulating their proliferation and differentiation.

16 Jul 2020

Dopaminergic neurones behave differently in different animals, shows study

Animals have an innate preference for certain scents and tastes. Attractive scents are linked to things like good food.

16 Jul 2020

Super-agers found to have increased resistance to tau and amyloid proteins

Super-agers, or individuals whose cognitive skills are above the norm even at an advanced age, have been found to have increased resistance to tau and amyloid proteins, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting.

15 Jul 2020

RNA editing may repair the underlying cause of Rett Syndrome in mouse model

A genomic error that causes Rett Syndrome, a serious lifelong neurological disorder, can be corrected in the brains of mice by rewriting the genetic instructions carried by the RNA.

15 Jul 2020

A tiny fish could end painful metabolic and genetic bone diseases

In a study published recently in Communications Biology, researchers led by Kanazawa University explain how a tiny fish could help end painful metabolic and genetic bone diseases.

15 Jul 2020

Strong evidence several FDA approved drugs block SARS-CoV-2 in relevant cell-lines and human organoids

Now, a new study describes how compounds that restore the normal transcriptional conditions following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be used to reduce viral load without neutralizing the virus entry into the host cell.

15 Jul 2020

Absolute Antibody and University of Zurich partner to offer novel SARS-CoV-2 sybodies

Absolute Antibody Ltd., an industry-leading provider of recombinant antibody products and services, today announced a partnership with University of Zurich to offer synthetic nanobodies against the receptor binding domain (RBD) of SARS-CoV-2, the coronavirus that causes COVID-19.

From Absolute Antibody Ltd 14 Jul 2020

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Researchers have developed a new pair of agents that show exceptional effectiveness for precision diagnosis and treatment of prostate cancer in preclinical studies.

13 Jul 2020

Bird poop may harbor abundant antibiotic resistance genes

Bird poop may pose more health risks than people realize, according to Rice University environmental engineers who study antibiotic resistance.

13 Jul 2020

Study sheds new light on neurobiological processes that control drug-related adaptations

The lab of Jeremy Day, Ph.D., at the University of Alabama at Birmingham, has used single-nucleus RNA sequencing approaches to compare transcriptional responses to acute cocaine in 16 unique cell populations from a portion of the brain called the nucleus accumbens, or NAc.

10 Jul 2020

Expansion stress promotes aggressive tumor cell growth in breast cancer

Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.

9 Jul 2020

Research shows how SARS-CoV-2 alters translation

Now, a new study published on the preprint server bioRxiv in July 2020 shows that the 5’ end of the RNA molecule is capable of inhibiting the binding of mRNA to the ribosomal 40S subunit, thus preventing translation.

9 Jul 2020

New technology can rapidly disrupt existing biofilms that account for chronic diseases

Chronic and recurrent bacterial diseases are treatment-resistant due to the ability of the pathogens to establish biofilms, which act as fortresses built of extracellular DNA and proteins to protect populations of the bacteria.

8 Jul 2020

Researchers develop bioprinted skin model of cutaneous squamous cell carcinoma

The cover for issue 27 of Oncotarget features "Bimodal imaging examples of control and treated tumors (red) before and after the treatment period," by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue.

7 Jul 2020

Researchers isolate protective antibodies for rare, polio-like disease in children

Researchers at Vanderbilt University Medical Center, Purdue University and the University of Wisconsin-Madison have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.

3 Jul 2020

in vivo News and Research

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

Oxytocin can help treat cognitive disorders

SARS-CoV-2 protein effectively shuts down production of proteins in the host, study shows

Groundbreaking technology could enhance therapeutic efficiency of nanomedicines

Study reveals antiviral effects of curcumin

Blood vessels communicate with sensory neurons to regulate their proliferation

Dopaminergic neurones behave differently in different animals, shows study

Super-agers found to have increased resistance to tau and amyloid proteins

RNA editing may repair the underlying cause of Rett Syndrome in mouse model

A tiny fish could end painful metabolic and genetic bone diseases

Strong evidence several FDA approved drugs block SARS-CoV-2 in relevant cell-lines and human organoids

Absolute Antibody and University of Zurich partner to offer novel SARS-CoV-2 sybodies

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Bird poop may harbor abundant antibiotic resistance genes

Study sheds new light on neurobiological processes that control drug-related adaptations

Expansion stress promotes aggressive tumor cell growth in breast cancer

Research shows how SARS-CoV-2 alters translation

New technology can rapidly disrupt existing biofilms that account for chronic diseases

Researchers develop bioprinted skin model of cutaneous squamous cell carcinoma

Researchers isolate protective antibodies for rare, polio-like disease in children

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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