Cell Death News and Research

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UGA investigators find viable treatment for prostate cancer

Researchers at the University of Georgia have created a new therapeutic for prostate cancer that has shown great efficacy in mouse models of the disease. They published their findings recently in the journal Nanomedicine: Nanotechnology, Biology and Medicine.

22 Mar 2016

Research shows how recreational ketamine abuse harms the bladder

Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder

21 Mar 2016

Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

Innovative treatment may help prevent brain swelling, death in stroke patients

New research has provided more evidence that an innovative treatment strategy may help prevent brain swelling and death in stroke patients. J. Marc Simard, professor of neurosurgery at the University of Maryland School of Medicine, along with colleagues at Yale University and Massachusetts General Hospital, found that Cirara, an investigational drug, powerfully reduced brain swelling and death in patients who had suffered a type of large stroke called malignant infarction, which normally carries a high mortality rate.

19 Mar 2016

Treatment guidelines need to be changed for rare, genetic form of diabetes, study suggests

Patients with a rare, genetic form of diabetes often are misdiagnosed as having type 2 diabetes because the two share symptoms.

18 Mar 2016

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.

17 Mar 2016

New drug shows promise against mesothelioma

A new drug is showing promise as a treatment for mesothelioma - one of the most lethal cancers of all.

15 Mar 2016

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Researchers report photoimmunotherapy to be effective against elusive gastric cancer cells following transduction with the gene that expresses the extracellular domain protein of HER2. The results are published in the journal Small Molecule Therapeutics in February 2016.

15 Mar 2016

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs lapatinib and trastuzumab before surgery and chemotherapy, saw their tumours shrink significantly or even disappear, according to results from a clinical trial.

11 Mar 2016

Researchers uncover antitumoral nature of maslinic acid in colon cancer cells

Researchers from the University of Granada, in collaboration with the universities of Barcelona and Jaen, have brought to light the antitumoral nature of maslinic acid (a compound derived from olives) in Caco-2 p53-deficient colon adenocarcinoma cells in the short term.

11 Mar 2016

Maternal bacterial infections affect fetal brain anatomy and cognitive functioning after birth

St. Jude Children's Research Hospital scientists have discovered how pieces of bacterial cell wall cross the placenta and enter developing neurons, altering fetal brain anatomy and cognitive functioning after birth. The study appears today in the scientific journal Cell Host & Microbe.

10 Mar 2016

UC San Diego physicians develop potential new therapy for critical limb ischemia

Bioengineers and physicians at the University of California, San Diego have developed a potential new therapy for critical limb ischemia, a condition that causes extremely poor circulation in the limbs and leads to an estimated 230,000 amputations every year in North America and Europe alone to prevent the spread of infection and tissue death.

9 Mar 2016

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

A study of obesity and related metabolic changes on bladder cancer incidence and deaths, and a plan to use stem cells to grow novel urinary tubes are among 10 research projects awarded funding by the Johns Hopkins Greenberg Bladder Cancer Institute.

7 Mar 2016

Leukemia researchers uncover protein that allows blood cancers to develop

Walter and Eliza Hall Institute researchers have uncovered a protein that is key to the development of blood cancers caused by a common genetic error.

7 Mar 2016

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with low survival rates, with newly diagnosed patients surviving a median of 14 months and recurrent patients surviving a median of only 3 to 9 months. New therapeutic targets and biomarkers for prognosis are urgently needed.

7 Mar 2016

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibiting the transfer of calcium ions into the cell's powerhouse is specifically toxic to cancer cells, according to an article published this week in Cell Reports by researchers from the Perelman School of Medicine at the University of Pennsylvania.

4 Mar 2016

Preterm neonatal progenitor cells may be a powerful tool for regeneration of damaged kidneys

Cells collected noninvasively from the urine of preterm infants may lead to breakthroughs in regenerative kidney repair for patients with kidney disease and injury, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

4 Mar 2016

Researchers uncover new pathway for mitochondrial cell death

Researchers at St. Jude Children's Research Hospital have uncovered a new pathway for mitochondrial cell death that involves the protein BCL-2 ovarian killer, otherwise known as BOK. The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer cells.

4 Mar 2016

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Researchers at Schepens Eye Research Institute of Massachusetts Eye and Ear have shown a link between mitochondrial dysfunction in corneal endothelial cells and the development of Fuchs' Endothelial Corneal Dystrophy.

4 Mar 2016

Cell-based immunotherapy may offer new hope in fight against brain cancer

High-grade glioma is the most aggressive form of brain cancer. Despite improvements in surgical procedures, chemotherapy, and radiotherapy, this type of brain tumour is still notoriously hard to treat: less than 10% of patients survive beyond five years.

3 Mar 2016

Cell Death News and Research

UGA investigators find viable treatment for prostate cancer

Research shows how recreational ketamine abuse harms the bladder

Novel compound shows promise as potential treatment for acute myeloid leukemia

Innovative treatment may help prevent brain swelling, death in stroke patients

Treatment guidelines need to be changed for rare, genetic form of diabetes, study suggests

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

New drug shows promise against mesothelioma

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Researchers uncover antitumoral nature of maslinic acid in colon cancer cells

Maternal bacterial infections affect fetal brain anatomy and cognitive functioning after birth

UC San Diego physicians develop potential new therapy for critical limb ischemia

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

Leukemia researchers uncover protein that allows blood cancers to develop

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Preterm neonatal progenitor cells may be a powerful tool for regeneration of damaged kidneys

Researchers uncover new pathway for mitochondrial cell death

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Cell-based immunotherapy may offer new hope in fight against brain cancer

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