Clinical Trial News and Research

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Scientists identify a new approach to treating sarcoidosis

A research team led by Georg Stary (Medical University of Vienna and CeMM) has identified a new approach to treating the inflammatory disease sarcoidosis.

23 Jan 2024

APOE4 genetic risk factors for Alzheimer's disease associated with increased risk of subclinical atherosclerosis

Scientists at the Centro Nacional de Investigaciones Cardiovasculares in Madrid have found that one of the most potent genetic risk factors for Alzheimer disease, apolipoprotein E4 (APOE4), is also associated with an increased risk of developing subclinical atherosclerosis in middle age.

23 Jan 2024

Study identifies genetic variants that influence response to preterm birth treatment

A UC San Francisco-led study has for the first time identified genetic variants that predict whether patients will respond to treatment for preterm birth, a condition that affects one in 10 infants born in the United States.

22 Jan 2024

Thinning brain tissue predicts dementia up to a decade before symptoms

A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported.

22 Jan 2024

Nicotine patches and e-cigarettes in pregnancy: A deep dive into risks and outcomes

Researchers examined the safety of e-cigarettes and nicotine-containing patches during pregnancy.

22 Jan 2024

Annexin-A1 targeted therapy beats several cancers

A new study published in Nature's cancer journal Oncogene highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumour progression.

19 Jan 2024

Clinical trial shows MRI and tracking-guided delivery of magnetic stimulation to brains of people with severe depression eases symptoms

Researchers performed a randomized clinical trial to compare resting-state functional magnetic resonance imaging connectivity-guided intermittent theta burst stimulation vs. repetitive transcranial magnetic stimulation for therapy-resistant depression.

19 Jan 2024

New device rapidly provides white blood cell count with a single drop of blood

A Rutgers researcher, through his spinoff company, has led a team to design and test a device that quickly counts a person's white blood cells with a single drop of blood, similar to the way glucometers rapidly scan for blood sugar levels.

18 Jan 2024

Play to prevent: Video games for preventing falls in community-dwelling older people

Researchers evaluated the effectiveness of home-based cognitive and exergame step training interventions compared with a control group in preventing falls among community-dwelling older adults.

18 Jan 2024

Combined cardio and strength workout effective against cardiovascular disease

Approximately one in three deaths in the U.S. is caused by cardiovascular disease, according to the U.S. Centers for Disease Control and Prevention. A robust body of evidence shows aerobic exercise can reduce risks, especially for people who are overweight or obese.

17 Jan 2024

Decoding blood cancer secrets to optimize CAR T therapy

Chimeric antigen receptor T-cell therapy, or CAR T, has dramatically improved the treatment of certain blood cancers. Initially approved for patients who had failed multiple lines of therapy, clinical trials have shown CAR T can be used as an earlier treatment option.

17 Jan 2024

Phase 3 trial shows acoramidis safe and effective for transthyretin amyloid cardiomyopathy

Pumping over 100,000 times a day, the heart is a critical muscle needed to deliver oxygen and nutrients to our organs to sustain healthy bodily function.

16 Jan 2024

Vanderbilt launches $13 million trial to test repurposed drugs for Rett syndrome

Vanderbilt University Medical Center received a $13 million Department of Defense grant to lead a multisite clinical trial that will evaluate repurposed FDA-approved drugs as treatment options for patients with Rett syndrome.

16 Jan 2024

New strategy makes palliative care more accessible to patients with chronic illnesses

Ordering a palliative care consultation by "default" – via an automatic order programmed into the electronic medical record that doctors may cancel if they choose – is an effective strategy to give more hospitalized patients the opportunity to benefit from palliative care, and sooner, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

16 Jan 2024

Exposure to AI models may reshape clinician's decisions and improve care outcomes

What if just observing Artificial Intelligence (AI) could make a clinician more efficient at their job and improve care outcomes for patients?

16 Jan 2024

Contact lenses monitor eye pressure for glaucoma prevention

Glaucoma effects around 70 million people worldwide and can cause irreversible loss of vision if not treated – but around half of those living with the condition are not aware of it.

16 Jan 2024

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the UK NHS through the 100,000 Genomes Cancer Programme.

16 Jan 2024

Paxlovid treatment in 20% of COVID-19 patients could avert 850,000 hospitalizations, save up to $170 billion

A study in the Emerging Infectious Diseases journal shows treating 20% of COVID-19 patients with Paxlovid could save up to 0.85 million lives and reduce the economic burden by US $170.17 billion in the US.

14 Jan 2024

Planning prompts show promise in improving prescribing safety

Physicians who are notified that a patient has died of a drug overdose are more judicious in issuing controlled substances if the notification includes a plan for what to do during subsequent patient visits, according to a study published today in Nature Communications.

13 Jan 2024

New study offers hope for reducing malaria in pregnant women living with HIV

In women living with HIV, preventive treatment with DHA-PPQ is a safe and effective strategy to prevent malaria during pregnancy, according to the final results of MAMAH, a clinical trial funded by the European & Developing Countries Clinical Trials Partnership (EDCTP) and coordinated by the Barcelona Institute for Global Health (ISGlobal), an institution supported by "la Caixa" Foundation.

12 Jan 2024

Clinical Trial News and Research

Scientists identify a new approach to treating sarcoidosis

APOE4 genetic risk factors for Alzheimer's disease associated with increased risk of subclinical atherosclerosis

Study identifies genetic variants that influence response to preterm birth treatment

Thinning brain tissue predicts dementia up to a decade before symptoms

Nicotine patches and e-cigarettes in pregnancy: A deep dive into risks and outcomes

Annexin-A1 targeted therapy beats several cancers

Clinical trial shows MRI and tracking-guided delivery of magnetic stimulation to brains of people with severe depression eases symptoms

New device rapidly provides white blood cell count with a single drop of blood

Play to prevent: Video games for preventing falls in community-dwelling older people

Combined cardio and strength workout effective against cardiovascular disease

Decoding blood cancer secrets to optimize CAR T therapy

Phase 3 trial shows acoramidis safe and effective for transthyretin amyloid cardiomyopathy

Vanderbilt launches $13 million trial to test repurposed drugs for Rett syndrome

New strategy makes palliative care more accessible to patients with chronic illnesses

Exposure to AI models may reshape clinician's decisions and improve care outcomes

Contact lenses monitor eye pressure for glaucoma prevention

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Paxlovid treatment in 20% of COVID-19 patients could avert 850,000 hospitalizations, save up to $170 billion

Planning prompts show promise in improving prescribing safety

New study offers hope for reducing malaria in pregnant women living with HIV

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