Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Isis Pharmaceuticals, AstraZeneca to develop antisense therapies for cardiovascular, metabolic, renal diseases

AstraZeneca and Isis Pharmaceuticals, Inc. today announced a strategic collaboration to discover and develop antisense therapies for cardiovascular, metabolic and renal diseases.

3 Aug 2015

John T. Spitznagel attains recognition in Strathmore's Who's Who for contributions in Healthcare Sales and Marketing

John T. Spitznagel of Glen Burnie, Maryland, has attained recognition in Strathmore's Who's Who for his contributions and achievements in the field of Healthcare Sales and Marketing. On Friday, July 31, 2015, he will be honored with a Times Square, New York appearance.

31 Jul 2015

Scientists produce functional liver cells from human embryonic and genetic engineered stem cells

The liver plays a critical role in human metabolism. As the gatekeeper of the digestive track, this massive organ is responsible for drug breakdown and is therefore the first to be injured due to overdose or misuse. Evaluating this drug-induced liver injury is a critical part of pharmaceutical drug discovery and must be carried out on human liver cells. Regretfully, human liver cells, called hepatocytes, are in scarce supply as they can only be isolated from donated organs.

31 Jul 2015

Natural protein fragment produced in the brain can inhibit enzyme implicated in Alzheimer's disease

For the first time, UCLA researchers have shown that a natural protein fragment produced in the brain can act as an inhibitor of a key enzyme implicated in the onset of Alzheimer's disease, a finding that could lead to the development of new drugs to treat the disease.

30 Jul 2015

GE Healthcare to invest more than $1 billion over five years in enhanced training for healthcare professionals

In developed countries like the U.S., Europe and parts of Asia, healthcare leaders are trying to optimize efficiency, systems integration, data analytics and achieve greater productivity. In emerging economies, enabling access to affordable, basic primary care is often the most pressing concern. Healthcare systems around the world face a wide range of difficult challenges. All could benefit from training and education solutions focused specifically on their particular needs.

29 Jul 2015

Study sheds light on current and potential treatment options for schistosomiasis

In a special free issue of Future Medicinal Chemistry, leading experts explore current and potential new treatment options for the deadly neglected tropical disease schistosomiasis.

28 Jul 2015

TSRI scientists awarded grant to explore therapeutic potential of protein receptors in Parkinson's disease, other disorders

Scientists from the Florida campus of The Scripps Research Institute have been awarded nearly $1.5 million from the National Institute of General Medical Sciences of the National Institutes of Health to explore the therapeutic potential of a class of proteins that play essential roles in the regulation and maintenance of human health.

28 Jul 2015

New computer algorithm helps scientists see drug's activity inside the body

Researchers at Columbia University Medical Center have developed a computer algorithm that is helping scientists see how drugs produce pharmacological effects inside the body. The study, published in the journal Cell, could help researchers create drugs that are more efficient and less prone to side effects, suggest ways to regulate a drug's activity, and identify novel therapeutic uses for new and existing compounds.

24 Jul 2015

Groundbreaking experimental therapy has ability to suppress ulcerative colitis

UCLA scientists have discovered a groundbreaking experimental therapy that has the ability to suppress the development of ulcerative colitis (UC), a disease which causes inflammation in the digestive tract and colon cancer. The treatment utilizes a chemical inhibitor able to block an RNA molecule (microRNA-214) involved in the transmission of genetic information.

24 Jul 2015

New Histone Antibody Specificity Database allows scientists to find right antibodies for biomedical research

For years, a crisis has been brewing in molecular biology. The problem is that antibodies--research tools used to identify key proteins at work in a cell--aren't always what they seem. Unreliable antibodies have led to numerous instances of false findings, failed experiments, and wasted money and samples.

24 Jul 2015

Gladstone Institutes announces new business endeavor with Evotec and Dolby Family Ventures

The Gladstone Institutes announces the creation of Cure Network Ventures Inc. and Cure Network Dolby Acceleration Partners, LLC, a business endeavor with Dolby Family Ventures and Evotec AG, which will focus on Alzheimer's disease. Working through Cure Network Ventures, Inc., the new company will help expedite the translation of relevant scientific discoveries from the Gladstone Institute of Neurological Disease into the development of potential therapies.

24 Jul 2015

Biomedical breakthrough reveals never-before-seen details of the body's cellular switchboard

A biomedical breakthrough, published today in the journal Nature, reveals never-before-seen details of the human body's cellular switchboard that regulates sensory and hormonal responses. The work is based on an X-ray laser experiment at the Department of Energy's SLAC National Accelerator Laboratory.

23 Jul 2015

New TripAdvisor-style website launched to help researchers choose better tools for biomedical research

An international panel of leading scientists is launching a new TripAdvisor-style website aimed at helping researchers choose better-quality research tools - and avoiding potentially serious errors in biomedical research.

22 Jul 2015

Researchers use iPSCs to explore new treatments for kidney disease

One promising way to treat diseased or damaged kidneys is cell therapies that include the transplantation of renal progenitor cells, which can then develop into the cells needed for full recovery. Acquiring a sufficient number of progenitor cells has been difficult, however, which is why scientists have considered induced pluripotent stem cells (iPSCs), since they can be expanded at significantly high levels and then differentiated into the progenitors.

22 Jul 2015

Scientists find potent agent that thwarts drug resistance in malaria parasite

Scientists have made an important breakthrough in the fight against malaria, identifying a potent agent that thwarts drug resistance in the parasite that causes the disease.

20 Jul 2015

Researchers demonstrate new multispectral microscope to speed up drug discovery

A new multispectral microscope, one capable of processing nearly 17 billion pixels representing 13 individual color channels in a single image, has been successfully demonstrated by a team of researchers from the United States and Australia. This is the largest such microscopic image ever created.

17 Jul 2015

Novel cancer drug candidate developed in Singapore advances into clinical trials

A made-in-Singapore cancer drug has advanced into clinical trials, charting a milestone in Singapore's biomedical sciences initiative that will go towards improving the lives of cancer patients in Singapore, and worldwide.

17 Jul 2015

Novogen's Anisina granted FDA Orphan Drug Designation for neuroblastoma

US-Australian drug discovery company, Novogen Limited, today announced that it has received notification from the U.S. Food and Drug Administration that its chemotherapy candidate drug, Anisina, has been granted Orphan Drug Designation for neuroblastoma.

16 Jul 2015

Discovery brings hope for people suffering from Parkinson's disease

Scientists from Singapore's Nanyang Technological University and McLean Hospital and Harvard Medical School in the United States have found that existing anti-malaria drugs could be a potential treatment for Parkinson's disease.

16 Jul 2015

New analysis explores importance of medical imaging in drug development, understanding pathological physiology

The use of small animal models in basic and preclinical research is now an integral part of developing and testing new pharmaceutical drugs prior to commercialisation.

14 Jul 2015

Drug Discovery News and Research

Further Reading

Isis Pharmaceuticals, AstraZeneca to develop antisense therapies for cardiovascular, metabolic, renal diseases

John T. Spitznagel attains recognition in Strathmore's Who's Who for contributions in Healthcare Sales and Marketing

Scientists produce functional liver cells from human embryonic and genetic engineered stem cells

Natural protein fragment produced in the brain can inhibit enzyme implicated in Alzheimer's disease

GE Healthcare to invest more than $1 billion over five years in enhanced training for healthcare professionals

Study sheds light on current and potential treatment options for schistosomiasis

TSRI scientists awarded grant to explore therapeutic potential of protein receptors in Parkinson's disease, other disorders

New computer algorithm helps scientists see drug's activity inside the body

Groundbreaking experimental therapy has ability to suppress ulcerative colitis

New Histone Antibody Specificity Database allows scientists to find right antibodies for biomedical research

Gladstone Institutes announces new business endeavor with Evotec and Dolby Family Ventures

Biomedical breakthrough reveals never-before-seen details of the body's cellular switchboard

New TripAdvisor-style website launched to help researchers choose better tools for biomedical research

Researchers use iPSCs to explore new treatments for kidney disease

Scientists find potent agent that thwarts drug resistance in malaria parasite

Researchers demonstrate new multispectral microscope to speed up drug discovery

Novel cancer drug candidate developed in Singapore advances into clinical trials

Novogen's Anisina granted FDA Orphan Drug Designation for neuroblastoma

Discovery brings hope for people suffering from Parkinson's disease

New analysis explores importance of medical imaging in drug development, understanding pathological physiology

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