Preclinical News and Research

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Mechano-immunological response to SARS-CoV-2

In a recent study, researchers demonstrated a human organ-on-a-chip (Organ Chip) microfluidic model of the lung alveolus (Alveolus Chip) - that recapitulates the human alveolar-capillary interface with an air-liquid interface (ALI) and vascular fluid flow to understand the local triggers in the lung in vitro.

5 May 2021

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children

Researchers have identified a gene expressed in children with acute myeloid leukemia (AML) that could serve as a new immunotherapy treatment target, according to a new study published today in Blood Advances, a journal of the American Society of Hematology.

5 May 2021

$3.5 million grant awarded to address the underrepresentation of Black adults in Alzheimer's research

Black adults are more likely than other groups to develop Alzheimer's disease or related disorders but are poorly represented in Alzheimer's disease research, including recent clinical trials. This health disparity illustrates how Black individuals can benefit from advances in the field if they had access.

4 May 2021

Moderna COVID-19 vaccine makes it on WHO Emergency Use Listing

Moderna has announced Emergency Use Listing granted by the World Health Organization for its COVID-19 mRNA vaccine.

4 May 2021

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

A vexing problem in the development of vaccines has been the need to achieve the right glycosylation profile for the viral antigens. A new study, recently released as a preprint on the bioRxiv* server, shows how a sequential cell-free approach produced complex N-glycans from simpler types, in a one-pot reaction.

4 May 2021

Vaccine candidate targeting SARS-CoV-2 nucleocapsid protein elicits protective immune response in animal model

New preclinical results from a study led by David Masopust of the University of Minnesota in Minneapolis, USA, show that a Had5-based vaccine targeting the nucleocapsid protein can also elicit a protective immune response.

3 May 2021

Competitive multiplex binding assay can monitor SARS-CoV-2 immune responses using nanobodies

Researchers at the Eberhard Karls University and the University of Tübingen in Germany described 11 unique nanobodies (Nbs) specific for the SARS-CoV-2 spike receptor-binding domain (RBD), of which 8 Nbs potentially inhibit the connection of RBD with the angiotensin-converting enzyme 2 (ACE2).

3 May 2021

Could portable air filters promote clearance of SARS-CoV-2-contaminated aerosols indoors?

A new study shows that inexpensive portable air cleaners may boost the removal of aerosols containing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from indoor spaces by as much as three times, compared to conventional Heating, Ventilation, and Air Conditioning (HVAC) systems.

30 Apr 2021

New study reveals mechanisms that result in lethal COVID-19

A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.

30 Apr 2021

Monoclonal antibody CT-P59 shows preclinical efficacy against South African SARS-CoV-2 variant

Researchers in the Republic of Korea (South Korea), The Netherlands, and South Africa have demonstrated the potential of the monoclonal antibody CT-P59 as an effective therapeutic for coronavirus disease 2019 (COVID-19) caused by the South African B.1.351 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

29 Apr 2021

City of Hope initiates Phase 2 clinical trial to investigate if mushroom tablets could slow prostate cancer

City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases, is now recruiting patients for a Phase 2 clinical trial to investigate whether pills containing white button mushroom extract could regulate the immune system, affecting prostate-specific antigen (PSA) levels to either remain stable or decline.

29 Apr 2021

New exosome-based therapeutic strategy to potentially treat late-stage colorectal cancer

In a recent discovery by University of Minnesota Medical School, researchers uncovered a new way to potentially target and treat late-stage colorectal cancer - a disease that kills more than 50,000 people each year in the United States.

29 Apr 2021

Algorithm interprets data from electronic medical records to diagnose kidney disease

Diagnosing chronic kidney disease, which is often undetected until it causes irreversible damage, may soon become automated with a new algorithm that interprets data from electronic medical records.

29 Apr 2021

Researchers receive $3.75 million to study the impact of fluid flow on CAR-T cell therapy for brain cancer

Glioblastoma multiforme is among the most lethal of cancers and the most stubborn in the face of treatment. Fewer than 20 percent of patients survive more than two years after diagnosis, according to the Central Brain Tumor Registry of the United States.

29 Apr 2021

Purified exosomal product accelerates wound healing in preclinical models

Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic.

28 Apr 2021

Peptide nucleocapsid vaccine candidate elicits protective T cell immunity against SARS-CoV-2 in vivo

A new study describes a synthetic peptide used as a platform to generate protective adaptive cellular immunity to the virus in rhesus macaques, which are the gold standard for preclinical testing in humans.

28 Apr 2021

New technique to hyperpolarize and purify fumarate for MRI

A promising new concept published by an interdisciplinary research team in "Proceedings of the National Academy of Sciences" (PNAS) paves the way for major advances in the field of magnetic resonance imaging (MRI). Their new technique could significantly simplify hyperpolarized MRI, which developed around 20 years ago for observing metabolic processes in the body.

28 Apr 2021

Preclinical News and Research

Mechano-immunological response to SARS-CoV-2

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children

$3.5 million grant awarded to address the underrepresentation of Black adults in Alzheimer's research

Moderna COVID-19 vaccine makes it on WHO Emergency Use Listing

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

Vaccine candidate targeting SARS-CoV-2 nucleocapsid protein elicits protective immune response in animal model

Competitive multiplex binding assay can monitor SARS-CoV-2 immune responses using nanobodies

Could portable air filters promote clearance of SARS-CoV-2-contaminated aerosols indoors?

New study reveals mechanisms that result in lethal COVID-19

Monoclonal antibody CT-P59 shows preclinical efficacy against South African SARS-CoV-2 variant

City of Hope initiates Phase 2 clinical trial to investigate if mushroom tablets could slow prostate cancer

New exosome-based therapeutic strategy to potentially treat late-stage colorectal cancer

Algorithm interprets data from electronic medical records to diagnose kidney disease

Researchers receive $3.75 million to study the impact of fluid flow on CAR-T cell therapy for brain cancer

Purified exosomal product accelerates wound healing in preclinical models

Peptide nucleocapsid vaccine candidate elicits protective T cell immunity against SARS-CoV-2 in vivo

New technique to hyperpolarize and purify fumarate for MRI

Some heart medications may facilitate SARS-CoV-2 infection through increasing ACE2 receptor levels

Drug cocktail can effectively activate and expand muscle stem cells

Prolactin hormone acts as a major contributor to breast cancer development, studies find

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