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Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

A study by a multidisciplinary team of researchers from The Saban Research Institute of Children's Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody combinatorial therapy to treat this cancer.

12 Oct 2016

Researchers aim to stop breast cancer metastasis from happening altogether

A new Tel Aviv University study finds that combining genetic therapy with chemotherapy delivered to a primary tumor site is extremely effective in preventing breast cancer metastasis.

5 Oct 2016

BUSM scientists discover new strategy to treat colon cancers driven by mutant KRAS genes

Researchers from Boston University School of Medicine have discovered a possible strategy to treat colon cancers that are caused by the mutant KRAS gene, which is responsible for approximately half of all colon cancer cases.

4 Oct 2016

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

A group of researchers, led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has shown that histone deacetylase (HDAC) inhibitors have the potential to eliminate stubborn reservoirs of breast and ovarian cancer stem cells (CSCs).

4 Oct 2016

Study suggests targeting UNG enzyme may help treat non-Hodgkin's lymphoma

Researchers have discovered that an enzyme called uracil-DNA glycosylase (UNG) protects the ends of B cell chromosomes to facilitate the proliferation of these antibody-producing cells in response to infection.

3 Oct 2016

Ki67 may help spare some breast cancer patients from sentinel lymph node biopsies

Breast cancer patients over 50 years old could be spared invasive procedures by use of stratification based on tumour size and molecular characteristics, including Ki67.

29 Sep 2016

Antibody drug offers new therapeutic approach for treating AML

An antibody drug that targets a surface marker on cancer stem cells could offer a promising new therapeutic approach for treating acute myeloid leukemia (AML), a form of blood cancer that affects an estimated 50,000 people in Saudi Arabia.

24 Sep 2016

U-M cardiologists reveal impact from shortage of radioactive elements used in cardiac stress testing

Nearly 15 million times a year, Americans with heart trouble climb onto a treadmill to take a stress test that can reveal blockages in their heart's blood vessels. It's a major factor in deciding what doctors should do next for them.

19 Sep 2016

Researchers uncover new molecular causes of brain cancer and leukemia

A joint research published today in Nature Communications has shown new molecular causes of brain cancer and leukemia.

14 Sep 2016

Study identifies new gene that suppresses breast cancer in mice

In recent years, the incidence of breast cancer has been increasing worldwide, and breast cancer is becoming a serious object of public concern.

13 Sep 2016

Cold plasma therapy may help treat non-healing wounds

Russian scientists at the Moscow Institute of Physics and Technology, the Joint Institute for High Temperatures of the Russian Academy of Sciences, and Gamaleya Research Centre of Epidemiology and Microbiology found that treating cells with cold plasma leads to their regeneration and rejuvenation.

13 Sep 2016

Researchers identify genes that regulate cellular senescence

A research group including Professor KAMADA Shinji, Research Fellow NAGANO Taiki (both from the Kobe University Biosignal Research Center), and Unit Chief ENARI Masato (National Cancer Research Institute) has succeeded in identifying genes that control cellular senescence - permanently arrested cell growth.

13 Sep 2016

Specific set of microRNAs could help diagnose and monitor IH treatment

Infantile hemangiomas (IH) are benign vascular tumors occurring in 4-5% of infants. These tumors resolve spontaneously or in response to propranolol treatment; however, they resemble other vascular anomalies and cannot be definitively diagnosed without biopsy.

9 Sep 2016

Researchers unlock genetic code that disrupts response to breast cancer therapy

Scientists may have unlocked the genetic code that determines why many patients with estrogen receptor-positive breast cancer fail to respond to the widely used drug tamoxifen.

7 Sep 2016

Tumor microenvironment acts as source of resistance to cancer therapies

Researchers at Bellvitge Biomedical Research Institute have published a new Oncotarget work which highlights the importance of the tumor environment as a source of resistance to treatment in colorectal cancer, the fourth most common cancer and the leading cause of cancer death worldwide.

7 Sep 2016

Nanomechanical microcantilevers can quickly detect mutations in patients with malignant melanoma

Changes in the genetic make-up of tissue samples can be detected quickly and easily using a new method based on nanotechnology.

6 Sep 2016

Advances in nuclear medicine production: an interview with Jayne Senior

In my view, one of the greatest changes in recent history that has come about in nuclear medicine production is Australia’s full adoption of Low-Enriched Uranium (LEU) technologies – in both the fuel and the target plates.

1 Sep 2016

Researchers discover protein that plays role in onset of type 1 diabetes

A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes.

31 Aug 2016

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

Research findings could lead to new ways of preventing or treating organ transplant rejection

An international team led by researchers from the University of Pittsburgh School of Medicine found that targeting certain donor cells lowered the risk of organ rejection in mice that underwent kidney and heart transplants.

24 Aug 2016

Proliferation News and Research

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

Researchers aim to stop breast cancer metastasis from happening altogether

BUSM scientists discover new strategy to treat colon cancers driven by mutant KRAS genes

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

Study suggests targeting UNG enzyme may help treat non-Hodgkin's lymphoma

Ki67 may help spare some breast cancer patients from sentinel lymph node biopsies

Antibody drug offers new therapeutic approach for treating AML

U-M cardiologists reveal impact from shortage of radioactive elements used in cardiac stress testing

Researchers uncover new molecular causes of brain cancer and leukemia

Study identifies new gene that suppresses breast cancer in mice

Cold plasma therapy may help treat non-healing wounds

Researchers identify genes that regulate cellular senescence

Specific set of microRNAs could help diagnose and monitor IH treatment

Researchers unlock genetic code that disrupts response to breast cancer therapy

Tumor microenvironment acts as source of resistance to cancer therapies

Nanomechanical microcantilevers can quickly detect mutations in patients with malignant melanoma

Advances in nuclear medicine production: an interview with Jayne Senior

Researchers discover protein that plays role in onset of type 1 diabetes

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Research findings could lead to new ways of preventing or treating organ transplant rejection

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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