Animal Model News and Research

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Studies on imaging and tracking transplanted cells

Successfully monitoring the distribution and fate of transplanted stem cells through imaging and subsequent tracking would aid clinicians in their ability to evaluate the efficacy of transplanted cells.

10 Dec 2008

Scans show immune cells intercepting parasites

Researchers may have identified one of the body's earliest responses to a group of parasites that causes illness in developing nations.

10 Dec 2008

Blocking immune receptor molecule improves response to HIV-like virus, prolongs survival in monkeys

By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV).

10 Dec 2008

Cytori reports benefit of adipose-derived regenerative cells in spinal disc model

Cytori Therapeutics, Inc. reported preclinical study results, which demonstrate the potential benefit of adipose-derived stem and regenerative cells (ADRCs) for the treatment of damaged intervertebral discs, evidenced by significantly increased disc tissue density and disc-specific extracellular matrix components at 12-months post treatment in a large animal model.

8 Dec 2008

Vitamin E supplementation may reduce inflammation in the brain

With up to half of a person's body mass consisting of skeletal muscle, chronic inflammation of those muscles - which include those found in the limbs - can result in significant physical impairment.

5 Dec 2008

Discovery of MEDNIK syndrome

Canadian researchers announce the discovery of MEDNIK Syndrome, a debilitating genetic syndrome.

5 Dec 2008

Potential new target for drugs to prevent HIV-associated dementia

A new study led by researchers at Albert Einstein College of Medicine of Yeshiva University has clarified how two major variants of HIV differ in their ability to cause neurologic complications.

3 Dec 2008

Natural killer T cells play important role in Lyme disease

A research team led by the La Jolla Institute for Allergy & Immunology and Albany Medical College has illuminated the important role of natural killer (NK) T cells in Lyme disease, demonstrating that the once little understood white blood cells are central to clearing the bacterial infection and reducing the intensity and duration of arthritis associated with Lyme disease.

3 Dec 2008

New hope for post-traumatic stress disorder sufferers

Post-traumatic stress disorder (PTSD) affects as many as one in five of all Americans who survive a harrowing experience like rape, assault, war or terrorism.

1 Dec 2008

Advance in K-Ras-mutated cancer research

A team of cancer researchers from several Boston academic medical centers has discovered a potential treatment for a group of tumors that have resisted previous targeted therapy approaches.

30 Nov 2008

Mouse model of prion disease mimics diverse symptoms of human disorder

A comprehensive mouse model of inherited prion disease exhibits cognitive, motor, and neurophysiological deficits that bear a striking resemblance to the symptoms experienced by patients with the human version of "mad cow disease," Creutzfeldt-Jakob disease (CJD).

26 Nov 2008

Researchers repair injured heart muscle with novel stem cells

Researchers at Children's Hospital of Pittsburgh of UPMC have been able to effectively repair damaged heart muscle in an animal model using a novel population of stem cells they discovered that is derived from human skeletal muscle tissue.

25 Nov 2008

A potential new procedure for treating obesity

Lining the upper portion of the small intestine with an impermeable sleeve led to both weight loss and restoration of normal glucose metabolism in an animal model of obesity-induced diabetes.

24 Nov 2008

Scientists identify blood component that turns anthrax bacteria virulent

Scientists from the Scripps Research Institute have discovered the key chemical that signals Bacillus anthracis , the bacterium that causes anthrax, to become lethal.

21 Nov 2008

Discovery of new gene linked to epilepsy

A University of Iowa-led international research team has found a new gene associated with the brain disorder epilepsy.

18 Nov 2008

Kynurenic acid in brain shows potential as schizophrenia target

New research has traced elevated levels of a specific compound in the brain to problem-solving deficits in patients with schizophrenia.

18 Nov 2008

Discovery of gene associated with epilepsy

A University of Iowa-led international research team has found a new gene associated with the brain disorder epilepsy.

18 Nov 2008

Cigarette smoke may reshape the left ventricle

Prolonged exposure to cigarette smoke can increase levels of the stress hormone norepinephrine and enzymes in the heart that have the potential to reshape the left ventricle, according to new research at the University of Illinois at Chicago.

16 Nov 2008

Discovery of mechanism that regulates the development of stem cells into neurons

Researchers at the University of Southern California (USC) have identified a novel mechanism in the regulation and differentiation of neural stem cells.

11 Nov 2008

Signaling between protein, growth factor is critical for coordinated cell migration

The mysterious process that orchestrates cells to move in unison to form human and animal embryos, heal wounds, and even spread cancer depends on interaction between two well-known genetic signaling pathways, two University of Utah medical school researchers have discovered.

11 Nov 2008