Cell Death News and Research

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Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the adrenal hormone aldosterone, which stimulates the heart to pump harder, causing greater damage to the heart muscle.

3 Mar 2016

New findings about prostate cells may identify future strategies for treating aggressive prostate cancer

A study that revealed new findings about prostate cells may point to future strategies for treating aggressive and therapy-resistant forms of prostate cancer.

1 Mar 2016

Novel mitochondria-specific ceria nanoparticles can effectively suppress neuronal cell death

The brain is an enormous network of communication, containing over 100 billion nerve cells, or neurons, with branches that connect at more than 100 trillion points. They are constantly sending signals through a vast neuron forest that forms memories, thoughts and feelings; these patterns of activity form the essence of each person.

27 Feb 2016

Researchers develop effective technique for studying high-arched palate using mouse model

Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality.

27 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

High-salt diet may contribute to liver damage

A sprinkle of salt can bring out the flavor of just about any dish. However, it's well known that too much can lead to high blood pressure, a potentially dangerous condition if left untreated.

24 Feb 2016

Ohio State researchers develop new approach to enhance heart function, cardiovascular performance

For the first time, scientists at The Ohio State University have engineered new calcium receptors for the heart to tune the strength of the heartbeat in an animal model. The research is published online by the journal Nature Communications.

24 Feb 2016

New biological technique may provide better, longer-lasting joint function

According to the Agency for Healthcare Research and Quality, more than 300,000 total hip replacements are performed in the United States each year. The procedure reduces pain and restores mobility. However, for younger, more active patients, an artificial hip has a limited lifetime and usually requires restricted activity.

23 Feb 2016

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

A medication approved to treat various respiratory diseases and that has demonstrated neuroprotective effects in preclinical studies is the focus of a new clinical trial for Parkinson's disease.

23 Feb 2016

Australian researchers reveal how nutlins pave way for improving future of cancer treatment

Australian researchers have resolved a mystery about how a promising new class of anti-cancer drugs, called nutlins, work - paving the way for improving the future of cancer treatment.

22 Feb 2016

Researchers identify common molecular alteration in glioblastoma

Glioblastoma is the most aggressive manifestation of brain tumours. Due to its high invasive capacity and uncontrolled, infiltrating growth, it is particularly difficult to manage. Currently, the treatment for this disease consists of a combination of surgery (when possible), radiation and chemotherapy.

22 Feb 2016

New UNC School of Medicine study shows how some bacteria can spread throughout the body

Bacteria have evolved thousands of clever tactics for invading our bodies while evading our natural defenses. Now, UNC School of Medicine scientists studying one of the world's most virulent pathogens and a separate very common bacterium have discovered a new way that some bacteria can spread rapidly throughout the body - by hitchhiking on our own immune cells.

16 Feb 2016

UAB research reveals heterogonous population of leukemia stem cells

University of Alabama at Birmingham researchers have found a marker on blood cells that may help the most pressing problem in chronic myelogenous leukemia, or CML, today — an inability to get patients off treatment.

16 Feb 2016

Research findings identify potential genetics-guided precision medicine for leukemia patients

An international research team has determined how inherited gene variations lead to severe drug toxicity that may threaten chances for a cure in children with leukemia. St. Jude Children's Research Hospital scientists led the study, results of which set the stage to expand the use of a patient's genetic make-up to tailor chemotherapy.

16 Feb 2016

Natural extract from India's neem tree shows promise against pancreatic cancer

A natural extract derived from India's neem tree could potentially be used to treat pancreatic cancer, according to a new study in the journal Scientific Reports.

12 Feb 2016

Lamin nucleoskeleton disordered in Alzheimer's

Brain cell death in Alzheimer's disease is linked to disruption of a skeleton that surrounds the nucleus of the cells, a researcher in the School of Medicine at The University of Texas Health Science Center at San Antonio said.

5 Feb 2016

Duke researchers identify promising target for renal cell carcinomas

All cells need nutrients, but cancer cells are notoriously power hungry. As a result, cancer cells must alter their metabolism to provide the additional fuel needed for them to survive, grow and spread.

4 Feb 2016

Discovery could lead to new leukaemia therapies

Human blood cells have olfactory receptors that respond to Sandalore. This could provide a starting point for new leukaemia therapies, as researchers from Bochum report in in the journal "Cell Death Discovery".

3 Feb 2016

Bile acid enables foetus to produce blood stem cells

A research group at Lund University in Sweden has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.

31 Jan 2016

MGH study may lead to first nonsurgical treatment for seborrheic keratoses

An investigation into the molecular mechanisms responsible for the most common type of benign skin lesion may lead to the first nonsurgical treatment for the growths called seborrheic keratoses (SKs), which in addition to being cosmetically unattractive are often worrisome to patients.

30 Jan 2016

Cell Death News and Research

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

New findings about prostate cells may identify future strategies for treating aggressive prostate cancer

Novel mitochondria-specific ceria nanoparticles can effectively suppress neuronal cell death

Researchers develop effective technique for studying high-arched palate using mouse model

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

High-salt diet may contribute to liver damage

Ohio State researchers develop new approach to enhance heart function, cardiovascular performance

New biological technique may provide better, longer-lasting joint function

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

Australian researchers reveal how nutlins pave way for improving future of cancer treatment

Researchers identify common molecular alteration in glioblastoma

New UNC School of Medicine study shows how some bacteria can spread throughout the body

UAB research reveals heterogonous population of leukemia stem cells

Research findings identify potential genetics-guided precision medicine for leukemia patients

Natural extract from India's neem tree shows promise against pancreatic cancer

Lamin nucleoskeleton disordered in Alzheimer's

Duke researchers identify promising target for renal cell carcinomas

Discovery could lead to new leukaemia therapies

Bile acid enables foetus to produce blood stem cells

MGH study may lead to first nonsurgical treatment for seborrheic keratoses

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