Clinical Trial News and Research

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Multi-faceted implementation strategy significantly lowers blood pressure in low-income patients

Uncontrolled hypertension, the leading preventable risk factor for cardiovascular disease and premature deaths worldwide, disproportionately affects low-income populations.

13 Nov 2023

Automated referrals to pharmacy services dramatically increase appropriate statin prescription rates

The odds of prescribing the appropriate dose of statins - a medicine used to lower "bad" cholesterol levels - increased sixfold when automated referrals were made to pharmacy services, instead of relying on traditional prescribing methods, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.

13 Nov 2023

One in five individuals taking nirmatrelvir-ritonavir therapy found to experience rebound COVID

A new study by investigators from Mass General Brigham found that one in five individuals taking Nirmatrelvir-ritonavir therapy, commonly known as Paxlovid, to treat severe symptoms of COVID-19, experienced a positive test result and shedding of live and potentially contagious virus following an initial recovery and negative test - a phenomenon known as virologic rebound.

13 Nov 2023

Optimal hydration post-exercise: Study compares sodium and carbohydrate levels in sports drinks for effective rehydration

In this study, researchers compared the effectiveness of sports drinks with varying carbohydrate and sodium levels for rehydrating athletes post-exercise, finding that drinks with higher sodium and lower carbohydrate content were more effective for rapid and complete rehydration. The study highlighted the importance of beverage composition in athlete recovery and hydration strategies.

13 Nov 2023

Major trial finds apixaban reduces stroke risk in patients with device-detected atrial fibrillation

The widely available blood thinner apixaban substantially reduced stroke in at-risk patients with a type of atrial fibrillation only detectable by a pacemaker or other implanted cardiac electronic device, a global study has found.

13 Nov 2023

Study finds rapid blood pressure reduction with low-sodium diet

Reducing daily sodium intake by around 4,000 mg/day significantly lowered systolic blood pressure in more than 70% of adults, ages 50 to 75, in as little as one week compared to their usual diet, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Current vitamin D dosing recommendations not high enough for optimal heart health, studies suggest

Low levels of Vitamin D have been shown to be associated with a higher risk of having a cardiac event, like a heart attack or stroke.

13 Nov 2023

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

Findings from a multi-center, international clinical trial reported by a Cleveland Clinic physician show that semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes.

13 Nov 2023

New hope for TB patients as UNITE4TB launches clinical trial program

Today, UNITE4TB, an international public-private partnership striving to fast-track the development of innovative Tuberculosis (TB) treatments, announced the start of its phase 2B/C clinical trial program with the first participant enrolled at its trial site in Cape Town, South Africa.

13 Nov 2023

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

AdvanCell, a radiopharmaceutical company developing a pipeline of Targeted Alpha Therapies for cancer patients, today announced the first patient was treated with 212Pb-ADVC001, a Targeted Alpha Therapy in development for the treatment of PSMA-positive metastatic Castration-Resistant Prostate Cancer (mCRPC).

13 Nov 2023

Liberal blood transfusion may reduce recurrence risk, improve survival in heart attack patients with anemia

An international clinical trial led by physician Jeffrey L. Carson, distinguished professor of medicine at Rutgers Robert Wood Johnson Medical School, found that a liberal blood transfusion given to patients who have had a heart attack and have anemia may reduce the risk of a reoccurrence and improve survival rates.

12 Nov 2023

Lowering sodium intake can help reduce blood pressure

Nearly everyone can lower their blood pressure, even people currently on blood pressure-reducing drugs, by lowering their sodium intake, reports a new study from Northwestern Medicine, Vanderbilt University Medical Center and the University of Alabama at Birmingham.

11 Nov 2023

One in six patients with coronary artery disease found to have non-ischemic or dual cardiomyopathy

Researchers from the University of Minnesota Medical School examining the cause of cardiomyopathy discovered one out of every six patients with coronary artery disease had non-ischemic or dual cardiomyopathy.

10 Nov 2023

Clinical trial underway for novel human milk-based microbiome therapy

In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient in a Phase 2a clinical trial evaluating a novel therapy for blood cancer patients undergoing allogeneic hematopoietic stem cell transplantation.

10 Nov 2023

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Some individuals with anti-Ro/SSA antibodies (anti–Sjögren's-syndrome–related antigen A autoantibodies, also called anti-Ro antibodies) have autoimmune diseases such as lupus or Sjögren's syndrome, but many have no symptoms.

10 Nov 2023

Ongoing study investigates if ultra-processed foods influence brain chemistry and obesity risk in young adults

Researchers are exploring how diets high in ultra-processed foods influence reward processing in the brain and potentially lead to increased food intake and obesity in young adults. This trial aims to clarify the effects of these foods on brain chemistry and decision-making during a critical developmental stage.

9 Nov 2023

WHO experts update guidance on COVID-19 treatments

A panel of international experts representing the World Health Organization's Guideline Development Group has updated its guidance on treatments for patients with covid-19.

9 Nov 2023

HMS immunologist unravels the mysteries of how the immune system communicates

The immune system is a crucial part of our survival, regularly fending off wide-ranging attacks on the body, both internal and external.

9 Nov 2023

C-Path releases new publication on transforming drug development for neurological disorders

Critical Path Institute (C-Path) is pleased to announce the release of a new peer-reviewed publication, titled "Transforming Drug Development for Neurological Disorders: Proceedings from a Multi-disease Area Workshop," now published in Neurotherapeutics, The Journal of the American Society for Experimental Neurotherapeutics.

9 Nov 2023

Laser hair removal reduces the risk of recurrence in patients with pilonidal disease

Laser epilation, commonly known as laser hair removal, reduced the risk of recurrence in patients with pilonidal disease, an inflammatory, painful, and sometimes chronic or recurring condition, according to research conducted by Peter C. Minneci, M.D., Chair of Surgery at Nemours Children's Health, Delaware Valley, and published in JAMA Surgery.

9 Nov 2023

Clinical Trial News and Research

Multi-faceted implementation strategy significantly lowers blood pressure in low-income patients

Automated referrals to pharmacy services dramatically increase appropriate statin prescription rates

One in five individuals taking nirmatrelvir-ritonavir therapy found to experience rebound COVID

Optimal hydration post-exercise: Study compares sodium and carbohydrate levels in sports drinks for effective rehydration

Major trial finds apixaban reduces stroke risk in patients with device-detected atrial fibrillation

Study finds rapid blood pressure reduction with low-sodium diet

Current vitamin D dosing recommendations not high enough for optimal heart health, studies suggest

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

New hope for TB patients as UNITE4TB launches clinical trial program

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

Liberal blood transfusion may reduce recurrence risk, improve survival in heart attack patients with anemia

Lowering sodium intake can help reduce blood pressure

One in six patients with coronary artery disease found to have non-ischemic or dual cardiomyopathy

Clinical trial underway for novel human milk-based microbiome therapy

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Ongoing study investigates if ultra-processed foods influence brain chemistry and obesity risk in young adults

WHO experts update guidance on COVID-19 treatments

HMS immunologist unravels the mysteries of how the immune system communicates

C-Path releases new publication on transforming drug development for neurological disorders

Laser hair removal reduces the risk of recurrence in patients with pilonidal disease

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