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Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Alzheimer's drug prescribed off-label could accelerate cognitive decline for some patients

Donepezil, a medication that is approved to treat people with Alzheimer's disease, should not be prescribed for people with mild cognitive impairment without a genetic test.

24 Feb 2017

Scientists unravel mechanism of rare, early phenomenon that can affect human development

The genetic material of an organism encodes the instructions that guide its development. These codes are not written in stone; they can change or mutate any time during the life of the organism.

24 Feb 2017

Researchers reveal biological pathways involved in diabetic kidney disease

Diabetes is a leading cause of kidney disease, a serious, often fatal complication that is difficult to diagnose in early, potentially treatable stages.

24 Feb 2017

Scientists create organ-on-a-chip that can mimic heart's biomechanical properties

The human heart beats more than 2.5 billion times in an average lifetime. Now scientists at Vanderbilt University have created a three-dimensional organ-on-a-chip that can mimic the heart's amazing biomechanical properties.

23 Feb 2017

Duke Health scientists identify proteins in mucous that confirm viral infection

It may seem obvious, but the key to confirming whether someone is suffering from a cold or flu virus might lie at the misery's source -- the inflamed passages of the nose and throat.

22 Feb 2017

Study shows potential of 3D tracking system in improving accuracy of robot-assisted surgery

The cutting-edge biocompatible near-infrared 3D tracking system used to guide the suturing in the first smart tissue autonomous robot surgery has the potential to improve manual and robot-assisted surgery and interventions through unobstructed 3D visibility and enhanced accuracy, according to a study published in the March 2017 issue of IEEE Transactions on Biomedical Engineering.

17 Feb 2017

DNAstack provides key support to strengthen global Internet of Genomics

Even though 60% of the global population resides in the African and Asian continents, only a small portion of these genomes have been sequenced, representing less than 0.2% of data currently collected. There are more than 4 billion people who are not represented well with the current genome sequencing efforts.

17 Feb 2017

Experts outline new methodologies that may lead to individualized patient care

In the current issue of Psychotherapy and Psychosomatic Dr. Ralph Horwitz and colleagues outline new methodologies, in addition to the well-known randomized controlled trials, to gather information that may lead to individualized patient care.

16 Feb 2017

World's largest GWAS on proteomics uncovers molecular mechanisms of complex diseases

The Helmholtz Zentrum München has published results of the largest genome-wide association study on proteomics to date.

16 Feb 2017

Researchers develop new automated platform for in-depth analyses of MRI scans

One of the main tools doctors use to detect diseases and injuries in cases ranging from multiple sclerosis to broken bones is magnetic resonance imaging.

16 Feb 2017

Scientists aim to create data mining tools to identify personalized treatment options for cancer

In the laboratories of Institute of Molecular Medicine Finland, drug testing is done ex vivo. That is, various leukemia drugs are tested with patient samples instead of the patients themselves. This enables the researchers to test different drug combinations efficiently and without burdening the patient.

13 Feb 2017

New drug discovered in zebrafish model of pediatric epilepsy shows promising results in clinical study

"Bench-to-bedside" describes research that has progressed from basic science in animal models that has led to therapies used in patients.

13 Feb 2017

Specific genetic errors that trigger congenital heart disease can be reproduced in common fruit fly

Specific genetic errors that trigger congenital heart disease (CHD) in humans can be reproduced reliably in Drosophila melanogaster - the common fruit fly - an initial step toward personalized therapies for patients in the future.

11 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

Study discovers new form of congenital muscular dystrophy caused by faulty INPP5K gene

A new form of congenital muscular dystrophy has been discovered which is caused by mutations in a previously un-linked gene.

9 Feb 2017

Researchers identify E. coli bacteria linking Crohn's disease to spondyloarthritis

Patients with Crohn's disease, a type of inflammatory bowel disease (IBD) that causes abdominal pain and diarrhea, can also experience joint pain.

9 Feb 2017

Horror movie scenes help researchers identify key neural pathway for processing fear

Researchers at the University of California, Irvine have identified a key neural pathway in humans that explains how the brain processes feelings of fear and anxiety, a finding that could help scientists unlock new ways to treat mental health disorders.

8 Feb 2017

NIH researchers identify genes that may predict how melanoma spreads

Cancerous tumors are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

8 Feb 2017

Studies open new windows into understanding untreatable group of common genetic disorders

Two Princeton University studies are opening important new windows into understanding an untreatable group of common genetic disorders known as RASopathies that are characterized by distinct facial features, developmental delays, cognitive impairment and heart problems.

7 Feb 2017

Precision Medicine News and Research

Using Spherical Nucleic Acids to Track and Treat Disease

Alzheimer's drug prescribed off-label could accelerate cognitive decline for some patients

Scientists unravel mechanism of rare, early phenomenon that can affect human development

Researchers reveal biological pathways involved in diabetic kidney disease

Scientists create organ-on-a-chip that can mimic heart's biomechanical properties

Duke Health scientists identify proteins in mucous that confirm viral infection

Study shows potential of 3D tracking system in improving accuracy of robot-assisted surgery

DNAstack provides key support to strengthen global Internet of Genomics

Experts outline new methodologies that may lead to individualized patient care

World's largest GWAS on proteomics uncovers molecular mechanisms of complex diseases

Researchers develop new automated platform for in-depth analyses of MRI scans

Scientists aim to create data mining tools to identify personalized treatment options for cancer

New drug discovered in zebrafish model of pediatric epilepsy shows promising results in clinical study

Specific genetic errors that trigger congenital heart disease can be reproduced in common fruit fly

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Study discovers new form of congenital muscular dystrophy caused by faulty INPP5K gene

Researchers identify E. coli bacteria linking Crohn's disease to spondyloarthritis

Horror movie scenes help researchers identify key neural pathway for processing fear

NIH researchers identify genes that may predict how melanoma spreads

Studies open new windows into understanding untreatable group of common genetic disorders

Event guide: The 4th Precision Medicine in Inflammatory Bowel Disease Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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