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Researchers investigate relationship between immune defenses and body size

What species is better at fighting an infection, a mouse or an elephant? Body size is one of the most noticeable differences among species, but relationships between immune defenses and body size have largely been unstudied.

25 Sep 2019

Scientists use new single-cell genetic technique to tackle potential drug resistance

Using a new technique that can identify genetic profiles of individual cells, University of Notre Dame researchers modeled a breast cancer tumor's potential resistance to a drug, and then identified a drug combination that reversed that resistance.

25 Sep 2019

Experimental treatment shows early promise to help nearly half of DMD patients

A new therapeutic being tested by University of Alberta researchers is showing early promise as a more effective treatment that could help nearly half of patients with Duchenne muscular dystrophy.

25 Sep 2019

Mystery underlying cardiac toxicity caused by diabetes drugs solved

Like catching two fish with one worm, treating two problems with a single drug is efficient, but exceedingly difficult.

25 Sep 2019

Metabolic imbalance in cancer patients associated with resistance to immune checkpoint blocker

A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute, in collaborative work with the Broad Institute of MIT and Harvard.

25 Sep 2019

Dormant HIV reservoirs could be killed with RNA switch

Researchers from the University of California San Diego School of Medicine have found cellular triggers within the immune cells that could be controlled in order to kill dormant HIV-1 reservoirs in individuals with HIV-1.

25 Sep 2019

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

25 Sep 2019

Monitoring the Human Proteome using diaPASEF

In this interview, Dr. Hannes Röst describes how his lab are using diaPASEF to monitor the human proteome throughout a person's lifetime, and how machine learning could be used to analyze the data.

From Bruker Daltonics 25 Sep 2019

Reactivating ‘tumor suppressor’ genes could offer new therapeutic approach for cancer

Scientists have developed a method which is able to switch ‘tumor suppressor’ genes back on after they have been silenced by cancer cells.

25 Sep 2019

Johns Hopkins researchers link a gene to melanoma growth and spread

Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3.

From Johns Hopkins Medicine 25 Sep 2019

Study on gene mutations may lead to better diagnosis and treatment for cancer

When a cell divides into two daughter cells, it must replicate its DNA according to a very specific scenario. In the presence of some disruptive elements, however, cancer cells are unable to perform this operation optimally; replication then takes place more slowly and less efficiently.

25 Sep 2019

New lab-on-a-chip system quickly identifies health aspects of a person's immune system

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a lab-on-a-chip system that can identify the health aspects of a person's immune system from a drop of their blood, within minutes.

25 Sep 2019

Epileptic seizures not likely to be predicted by changes in brain wave patterns

Until now, certain brain wave patterns were regarded as indicators; however, a study by the University of Bonn did not find any evidence for this Epileptic seizures can probably not be predicted by changes in brain wave patterns that were previously assumed to be characteristic precursors.

25 Sep 2019

MR Solutions’ new liquid helium-free PET-MR system to be displayed at WMIC

MR Solutions’ latest liquid helium free PET-MR preclinical imaging system for the molecular research community was the subject of talks and papers on simultaneous PET-MR imaging at the World Molecular Imaging Congress held in Montreal in September.

From MR Solutions 25 Sep 2019

The ear's sensitivity to sound is controlled by outer hair cells

The human inner ear has a type of cell called the outer hair cell. These were thought to amplify sounds from the environment. However, a new study based on hearing in gerbils shows these cells are probably involved in regulating the sensitivity of the ear to sound. This could help find ways to preserve good hearing by protecting these cells from destruction.

25 Sep 2019

TUM researchers reveal how chaperones detect immature immune signaling proteins

The cells of our immune system constantly communicate with one another by exchanging complex protein molecules.

24 Sep 2019

Tapeworms need their head for stem cell-driven regeneration

Scientists have identified the stem cells that allow tapeworms to regenerate and found that their location in proximity to the head is essential, according to a new study in eLife.

24 Sep 2019

Researchers identify key switch that eliminates dormant HIV reservoirs

Using genetic sequencing, University of California San Diego School of Medicine researchers have identified a principal cellular player controlling HIV reproduction in immune cells which, when turned off or deleted, eliminates dormant HIV reservoirs.

24 Sep 2019

Electronic conversations between neurons could soon be recorded precisely

Electrodes are used to pick up electrical signals. Neurons however are tiny units of the nervous system and it is difficult to create an electrode small enough to record all the workings of a neurons.

24 Sep 2019

Wistar awarded more than $12 million to study opioid use in HIV-infected people

The Wistar Institute was awarded two major grants totaling more than $12 million from the National Institute on Drug Abuse, part of the National Institutes of Health, to fund an international multidisciplinary clinical research consortium spearheaded by Wistar's HIV Research Program.

24 Sep 2019