Animal Model News and Research

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First animal model that mimics human head and neck cancer

An Oregon Health & Science University Cancer Institute research laboratory has developed a novel mouse model designed specifically to study the often devastating head and neck squamous cell cancers.

16 May 2006

New technique for freezing and preserving genetically enhanced pig embryos

Researchers led by a University of Missouri-Columbia professor of reproductive biotechnology have reported success in freezing and preserving swine embryos that were created by in vitro techniques and that carried modified genetic material.

3 May 2006

Researchers identify novel agent that protects neurons involved in Parkinson's disease from being destroyed by rotenone

Researchers at the University at Buffalo affiliated with the New York State Center of Excellence in Bioinformatics and Life Sciences have identified a novel agent that can protect neurons involved in Parkinson's disease from being destroyed by the pesticide rotenone.

18 Apr 2006

Genetic switch that links animal growth and cancer

Laboratory discoveries by scientists at two universities may lead to new directions in cancer therapy drugs. The researchers have discovered that a genetic switch involved in growth and development of an animal is the same one used to prevent normal cells from becoming cancerous.

18 Apr 2006

First evidence that circulating endothelial microparticles lead to heart valve disease

Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium - the cells that line the inside of blood vessels and some organs -and appear to cause no problems.

13 Apr 2006

Sildenafil improves blood flow after heart attack in an animal model

Dogs treated with sildenafil, a drug most commonly used to treat erectile dysfunction, had better blood flow in coronary arteries than control animals, following an induced artery obstruction and treatment that modeled a heart attack and standard medical care given to people

13 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

Research explains why recipients of growth hormone therapy may develop colon polyps

The use of growth hormone therapy has been linked in some people to the development of colon polyps, a possible precursor to colorectal cancer - but medical researchers have debated the extent of a cancer risk.

11 Apr 2006

Antifibrotic effect of hepatocyte growth factor is impaired in lung fibroblasts isolated from African-Americans

Of the more than 40,000 persons who die each year in the U.S. from pulmonary fibrosis, the mortality rate among African-Americans is twice as high Caucasians.

11 Apr 2006

Protein loss linked to colon polyp risk from growth hormone

10 Apr 2006

Cancer virus protein p13 needed for successful infection and reproduction

New research shows that a protein made by a cancer-causing virus that was thought to be unimportant for its replication is in fact critically needed by the virus to initiate an infection and to reproduce.

4 Apr 2006

Researchers reverse juvenile diabetes in animal model

Groundbreaking human clinical trial for type 1 diabetes to start this spring in Pittsburgh - Children's Hospital of Pittsburgh of UPMC researchers reverse juvenile diabetes in animal model; Phase 1 clinical trial approved by FDA.

4 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

PR Pharmaceuticals issued U.S. patent covering 2-methoxyestradiol for the treatment of diabetes

The patent which is assigned to the University of Pittsburgh has been exclusively licensed to PRP. The drug, known as PulmoLAR, containing 2ME as active ingredient, is currently developed by PRP for the treatment of pulmonary arterial hypertension (PAH).

21 Mar 2006

Genetic factors underlie alcohol consumption and may also contribute to nicotine addiction

Vulnerability to both alcohol and nicotine abuse may be influenced by the same genetic factor, according to a recent study supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).

20 Mar 2006

Newly discovered genetic mechanism in poultry can provide more insights to complex diseases

Scientists from Uppsala University, the Swedish University of Agricultural Sciences, and the U.S. have identified a genetic mechanism that regulates growth in chickens.

13 Mar 2006

New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease.

13 Mar 2006

Repligen commences phase 2 trial of RG2417 for bipolar depression

Repligen Corporation today announced that the Company has initiated a Phase 2 clinical trial of RG2417, an oral formulation of uridine, in patients with bipolar depression.

9 Mar 2006

New genome-wide map of miRNA-MRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

9 Mar 2006

Why people of African descent are more vulnerable to tuberculosis infection

A team of scientists has identified a cellular mechanism that may help explain the puzzle of why people of African descent are more susceptible to tuberculosis infection and why, once infected, they develop more severe states of the disease than whites.

27 Feb 2006

Animal Model News and Research

First animal model that mimics human head and neck cancer

New technique for freezing and preserving genetically enhanced pig embryos

Researchers identify novel agent that protects neurons involved in Parkinson's disease from being destroyed by rotenone

Genetic switch that links animal growth and cancer

First evidence that circulating endothelial microparticles lead to heart valve disease

Sildenafil improves blood flow after heart attack in an animal model

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

Research explains why recipients of growth hormone therapy may develop colon polyps

Antifibrotic effect of hepatocyte growth factor is impaired in lung fibroblasts isolated from African-Americans

Protein loss linked to colon polyp risk from growth hormone

Cancer virus protein p13 needed for successful infection and reproduction

Researchers reverse juvenile diabetes in animal model

Targeting the inflamed synovium: The quest for specificity

PR Pharmaceuticals issued U.S. patent covering 2-methoxyestradiol for the treatment of diabetes

Genetic factors underlie alcohol consumption and may also contribute to nicotine addiction

Newly discovered genetic mechanism in poultry can provide more insights to complex diseases

New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

Repligen commences phase 2 trial of RG2417 for bipolar depression

New genome-wide map of miRNA-MRNA interactions

Why people of African descent are more vulnerable to tuberculosis infection

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

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