Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Trace substance in sugar improves muscle regeneration in mouse model with muscular dystrophy

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy. The findings are published today, Aug. 1, in the journal Skeletal Muscle.

2 Aug 2013

Breath analysis: Noninvasive way to quickly determine severity of bacterial infections

Breath analysis may prove to be an accurate, noninvasive way to quickly determine the severity of bacterial and other infections, according to a UC Irvine study appearing online today in the open-access journal PLOS ONE.

2 Aug 2013

Finding could influence effectiveness of bone marrow transplants for late-stage leukemia

Eight years ago, two former Stanford University postdoctoral fellows, one of them still in California and the other at the Harvard Stem Cell Institute in Cambridge, began exchanging theories about why patients with leukemia stop producing healthy blood cells. What was it, they asked, that caused bone marrow to stop producing normal blood-producing cells?

1 Aug 2013

Miniscule signaling molecule plays critical role in certain acute and chronic diseases

Scientists seeking to harness the healing power of a miniscule signaling molecule that plays a critical role in certain acute and chronic diseases have been awarded a Program Project Grant (PPG) of nearly $10 million by the National Heart, Lung and Blood Institute of the National Institutes of Health.

1 Aug 2013

AstraZeneca, FibroGen partner to develop, commercialize anemia drug candidate FG-4592

AstraZeneca and FibroGen today announced that they have entered into a strategic collaboration to develop and commercialize FG-4592, a first-in-class oral compound in late stage development for the treatment of anemia associated with chronic kidney disease and end-stage renal disease.

31 Jul 2013

FibroGen, Astellas initiate Phase 2 study of ASP1517/FG-4592 for treatment of anemia linked with CKD

Astellas Pharma Inc. (Tokyo:4503) (Astellas) and FibroGen, Inc. (FibroGen) announced today the initiation of a Phase 2 clinical study in Japan of ASP1517/FG-4592 for treatment of anemia associated with chronic kidney disease (CKD) in patients on dialysis.

31 Jul 2013

Hope for treatment of childhood infections may come straight from the gut: Therapeutic poop

Call it therapeutic poop, if you will, but the best hope yet for an effective treatment of childhood infections with the drug-resistant bacterium C. difficile may come straight from the gut, according to recent research.

30 Jul 2013

Weekend reading: The mystery of some innovations that are slow to be accepted; myths about the obesity crisis

Why do some innovations spread so swiftly and others so slowly? Consider the very different trajectories of surgical anesthesia and antiseptics. ... On October 16, 1846, at Massachusetts General Hospital, Morton administered his gas through an inhaler in the mouth of a young man undergoing the excision of a tumor in his jaw. ... By February, anesthesia had been used in almost all the capitals of Europe, and by June in most regions of the world.

26 Jul 2013

NOXXON completes patient recruitment of NOX-E36 Phase IIa trial for treatment of diabetic nephropathy

NOXXON Pharma today announced the successful completion of patient recruitment of its NOX-E36 Phase IIa clinical trial for the treatment of diabetic nephropathy. NOX-E36 is a Spiegelmer® that binds and neutralizes CCL2/MCP-1 (C-C Chemokine Ligand / Monocyte Chemoattractant Protein-1), a pro-inflammatory chemokine that plays an important role in the progression of diabetic nephropathy, the most common single cause of chronic kidney failure and end-stage renal disease.

25 Jul 2013

Innovative microsurgery technique helps prevent lymphedema in patients with breast cancer

A team of surgeons and members of the breast cancer program of the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center is conducting a two-year pilot study of an innovative microsurgery technique coupled with imaging technology to not only prevent lymphedema but also potentially detect and treat it early.

24 Jul 2013

WHO urges governments to act against five hepatitis viruses that cause severe liver infections

On World Hepatitis Day (28 July), the World Health Organization (WHO) is urging governments to act against the five hepatitis viruses that can cause severe liver infections and lead to 1.4 million deaths every year. Some of these hepatitis viruses, most notably types B and C, can also lead to chronic and debilitating illnesses such as liver cancer and cirrhosis, in addition to loss of income and high medical expenses for hundreds of millions of people worldwide.

24 Jul 2013

NIH awards $2.35M grant to BUSM researcher to study the development of gonococcal vaccine

Lee Wetzler, MD, an attending physician in the department of infectious diseases at Boston Medical Center and associate program director for research in the section of infectious diseases at Boston University School of Medicine (BUSM), was awarded a four-year, $2.35 million grant from the National Institutes of Health (NIH) to study the development of a gonococcal vaccine.

24 Jul 2013

Implications for treating some common food allergies

Food is an integral part of life; but, for some, it can be harmful. Allergic inflammation caused by inappropriate immune responses to some types of food has become a major public health issue. Over the past ten years, the prevalence of food allergies has increased by nearly 20 percent, affecting an estimated six million people in the U.S.

22 Jul 2013

Scientists to explore student-driven research model for Distributed Drug Discovery

Purdue University Indianapolis (IUPUI) will host scientists from around the world next week for the first-ever workshop devoted to Distributed Drug Discovery, an innovative, student-driven research program quickly becoming a high-impact, low-cost teaching model.

20 Jul 2013

Researchers visualize live cell-to-cell communication pathways in bacteria

Most bacteria are able to communicate with each other by secreting signaling molecules. Once the concentration of signals has reached a critical density (-the Quorum), the bacteria are able to coordinate their behavior

20 Jul 2013

MedUni Vienna cardiologist demonstrates effectiveness of substance that makes heart softer

Heart failure with concomitant pulmonary hypertension is a growing health problem with a high mortality rate, above all in older people. The cardiologist Diana Bonderman from the University Department of Internal Medicine II at the MedUni Vienna, as the author of a multinational phase II study, has demonstrated the effectiveness of a substance that sticks to the so-called nitric oxide pathway and makes the heart "softer".

19 Jul 2013

Cancer patients who receive chest radiation should screen for heart disease every 5-10 years

Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years, according to the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC) and the American Society of Echocardiography (ASE).

17 Jul 2013

Drug to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle--a disorder that often leads to heart failure, researchers at the University of Illinois at Chicago College of Medicine report.

17 Jul 2013

Study provides insight into how primary care patients experience genetic testing

Several companies sell genetic testing directly to consumers, but little research has been done on how consumers experience such tests. The tests have raised questions about the validity and accuracy of the information provided to consumers - especially without the involvement of a qualified health care professional.

16 Jul 2013

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

As surgeons who take care of cancer patients, we have observed a troubling association between patients who suffer from infections after surgery and the rapid spread of their cancer. We have reported this in lung cancer patients, and others have made these observations in a variety of different cancers. However, the mechanisms responsible for this association are still poorly understood.

16 Jul 2013

Fibrosis News and Research

Further Reading

Trace substance in sugar improves muscle regeneration in mouse model with muscular dystrophy

Breath analysis: Noninvasive way to quickly determine severity of bacterial infections

Finding could influence effectiveness of bone marrow transplants for late-stage leukemia

Miniscule signaling molecule plays critical role in certain acute and chronic diseases

AstraZeneca, FibroGen partner to develop, commercialize anemia drug candidate FG-4592

FibroGen, Astellas initiate Phase 2 study of ASP1517/FG-4592 for treatment of anemia linked with CKD

Hope for treatment of childhood infections may come straight from the gut: Therapeutic poop

Weekend reading: The mystery of some innovations that are slow to be accepted; myths about the obesity crisis

NOXXON completes patient recruitment of NOX-E36 Phase IIa trial for treatment of diabetic nephropathy

Innovative microsurgery technique helps prevent lymphedema in patients with breast cancer

WHO urges governments to act against five hepatitis viruses that cause severe liver infections

NIH awards $2.35M grant to BUSM researcher to study the development of gonococcal vaccine

Implications for treating some common food allergies

Scientists to explore student-driven research model for Distributed Drug Discovery

Researchers visualize live cell-to-cell communication pathways in bacteria

MedUni Vienna cardiologist demonstrates effectiveness of substance that makes heart softer

Cancer patients who receive chest radiation should screen for heart disease every 5-10 years

Drug to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy

Study provides insight into how primary care patients experience genetic testing

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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