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Topiramate reduces drinking in patients committed to abstinence from alcohol

Heavy drinking alcohol consumption is common in the United States and takes a personal and societal toll, with an annual estimated cost of $223.5 billion due to losses in workplace productivity, and health care and criminal justice expenses.

14 Feb 2014

Researchers find unique role for p66Shc adaptor protein in regulating glucose and cell growth

A protein that has been known until recently as part of a complex communications network within the cell also plays a direct role in regulating sugar metabolism, according to a new study published on-line in the journal Science Signaling (February 18, 2014).

14 Feb 2014

FDA approves Biologics’ IMBRUVICA as oral agent for treatment of patients with CLL

Biologics, a limited distribution network partner for IMBRUVICA™ (ibrutinib), is pleased to announce the U.S. Food and Drug Administration (FDA) has approved IMBRUVICA™ (ibrutinib) capsules as a single, oral agent for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.

14 Feb 2014

Brain's ability to rebuild itself after stroke holds promise for treating long-term disability in adults

Enhancing the brain's inherent ability to rebuild itself after a stroke with molecular components of stem cells holds enormous promise for treating the leading cause of long-term disability in adults.

14 Feb 2014

Prothelia, University of Nevada, Reno and Alexion partner to develop Laminin-111 for MDC1A

Prothelia Incorporated and University of Nevada, Reno announce that they have entered into strategic agreements with Alexion for the development of Laminin-111, a patented experimental protein replacement therapy for merosin-deficient congenital muscular dystrophy (MDC1A), a life-threatening, ultra-rare disease caused by a genetic deficiency of the Laminin-211 protein.

13 Feb 2014

Intravenous magnesium fails to improve stroke-related disability

Giving intravenous magnesium to stroke patients soon after the start of symptoms, in an attempt to protect brain cells deprived of oxygen, failed to improve stroke-related disability 3 months later, according to research presented at the American Stroke Association's International Stroke Conference 2014

13 Feb 2014

Moderate-intensity exercise reduces stroke risk in women

Women don't need to run marathons or do intense aerobics to reduce their stroke risk. Moderate-intensity exercise - such as brisk walking or playing tennis -- may do the trick, according to research presented at the American Stroke Association's International Stroke Conference 2014.

13 Feb 2014

Aerpio Therapeutics doses first patient in AKB-9778 Phase 2 trial for diabetic macular edema treatment

Aerpio Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on advancing innovative therapies for vascular diseases, today announced that it has dosed the first patient in a Phase 2 trial evaluating AKB-9778, a Tie2 activator, alone and in combination with ranibizumab (Lucentis) for the treatment of diabetic macular edema (DME). AKB-9778 is a first-in-class inhibitor of human protein tyrosine phosphatase beta (HPTPβ) that activates the Tie2 pathway to promote vascular stability, preventing abnormal blood vessel growth and vascular leak.

13 Feb 2014

Clot-busting tPA therapy for ischemic stroke patients can avoid lengthy, restrictive monitoring in ICU

A Johns Hopkins study of patients with ischemic stroke suggests that many of those who receive prompt hospital treatment with "clot-busting" tissue plasminogen activator (tPA) therapy can avoid lengthy, restrictive monitoring in an intensive care unit (ICU).

13 Feb 2014

Study reveals that more than 14% of pregnant women are prescribed opioids for pain

More than 14 percent of pregnant women were prescribed opioids (narcotics) for pain at some time during their pregnancy, according to a study posted to the online version of Anesthesiology.

13 Feb 2014

Alvogen launches Inflectra into Central and Eastern Europe

Alvogen, the multinational pharmaceuticals company, today announced the launch of Inflectra (Infliximab) into Central and Eastern Europe. Inflectra, Europe's first biosimilar monoclonal antibody (mAb) therapy that has been approved for the treatment of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), ulcerative colitis (UC), psoriatic arthritis (PsA) and psoriasis.

13 Feb 2014

Severe skin reactions during radiation therapy could be prevented by applying silicone dressing

Severe skin reactions during radiation therapy could be prevented by applying a thin transparent silicone dressing to the skin from the first day of treatment, clinical research from New Zealand shows.

13 Feb 2014

UMMS launches Voyager Therapeutics to develop life-changing treatments for fatal diseases

UMass Medical School (UMMS) recognizes the launch today of Voyager Therapeutics, a gene therapy company founded by four world leaders in the fields of AAV gene therapy, RNA biology and neuroscience, to develop life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS).

13 Feb 2014

Researchers discover pre-leukemic stem cell that triggers relapse in patients with AML

Cancer researchers led by stem cell scientist Dr. John Dick have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML).

13 Feb 2014

LA BioMed researchers test investigational drug for treatment of Sanfilippo B syndrome

A promising new therapy has - for the first time - reduced damage to the brain that can be caused by Sanfilippo B (MPS IIIB), a rare and devastating genetic disease, Los Angeles Biomedical Research Institute researchers will report today in a presentation at the Lysosomal Disease Network's 10th Annual WORLD Symposium-.

12 Feb 2014

Novel compound appears to protect mice against movement problems associated with PD

Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson's disease (PD). The research, which could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease, appears in ACS' Journal of Medicinal Chemistry.

12 Feb 2014

Understanding genetic changes associated with aggressive prostate cancer

Researchers at the University of East Anglia have made an important advance in understanding genetic changes associated with terminal prostate cancer.

12 Feb 2014

MIT develops robot that may speed up drug development for stroke patients

The development of drugs to treat acute stroke or aid in stroke recovery is a multibillion-dollar endeavor that only rarely pays off in the form of government-approved pharmaceuticals.

12 Feb 2014

Manchester researchers become first in world to assess all genetic links with fungal lung infection CPA

A grandfather-of-three from Tameside is helping University of Manchester researchers become the first in the world to assess all the genetic links with Chronic Pulmonary Aspergillosis (CPA) - a debilitating fungal lung infection that claims the lives of thousands of people in the UK and millions more worldwide.

From The University of Manchester 12 Feb 2014

New research reveals potential link between alcohol consumption and breast cancer

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

From The University of Manchester 12 Feb 2014

Therapy News and Research

Topiramate reduces drinking in patients committed to abstinence from alcohol

Researchers find unique role for p66Shc adaptor protein in regulating glucose and cell growth

FDA approves Biologics’ IMBRUVICA as oral agent for treatment of patients with CLL

Brain's ability to rebuild itself after stroke holds promise for treating long-term disability in adults

Prothelia, University of Nevada, Reno and Alexion partner to develop Laminin-111 for MDC1A

Intravenous magnesium fails to improve stroke-related disability

Moderate-intensity exercise reduces stroke risk in women

Aerpio Therapeutics doses first patient in AKB-9778 Phase 2 trial for diabetic macular edema treatment

Clot-busting tPA therapy for ischemic stroke patients can avoid lengthy, restrictive monitoring in ICU

Study reveals that more than 14% of pregnant women are prescribed opioids for pain

Alvogen launches Inflectra into Central and Eastern Europe

Severe skin reactions during radiation therapy could be prevented by applying silicone dressing

UMMS launches Voyager Therapeutics to develop life-changing treatments for fatal diseases

Researchers discover pre-leukemic stem cell that triggers relapse in patients with AML

LA BioMed researchers test investigational drug for treatment of Sanfilippo B syndrome

Novel compound appears to protect mice against movement problems associated with PD

Understanding genetic changes associated with aggressive prostate cancer

MIT develops robot that may speed up drug development for stroke patients

Manchester researchers become first in world to assess all genetic links with fungal lung infection CPA

New research reveals potential link between alcohol consumption and breast cancer

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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