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Agena Bioscience expands ultrasensitive somatic mutation detection technology

Agena Bioscience, Inc., which recently acquired the Bioscience business of Sequenom, Inc., today announced expansion of the UltraSEEK™ technology, the first ultrasensitive somatic mutation detection technology for high-throughput and definitive interrogation of rare mutations that occur at less than 1% abundance in matched tissue, circulating plasma, and tumor samples.

31 May 2014

Health advocates allege 4 Fla. insurers discriminate against HIV patients

In a complaint to federal officials, the groups say the companies set high out-of-pocket costs for drugs to treat HIV and AIDS in an effort to discourage gay patients from picking the plans.

31 May 2014

FDA grants Angiochem’s ANG1005 fast track and orphan drug designation for treatment of glioblastoma multiforme

Angiochem announced today that the Food & Drug Association (FDA) has granted both orphan drug and fast track designation to ANG1005 a novel paclitaxel-peptide drug conjugate leveraging the low density lipoprotein receptor-related protein 1 (LRP-1) pathway to cross the blood-brain barrier (BBB) and enter cancer, for the treatment of glioblastoma multiforme (GBM).

31 May 2014

Angiochem commences ANG1005 Phase 2 clinical study in HER2+ breast cancer patients with brain metastases

Angiochem, a clinical stage biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier (BBB), today announced the initiation of a Phase 2 clinical study with ANG1005, a novel paclitaxel-peptide drug conjugate, in HER2+ breast cancer patients.

31 May 2014

10,000 toddlers receive medication for ADHD, shows report

"It does not surprise me that some children are being given medicine as the easy way out but that doesn't mean it's the right way to do it," says Max Wiznitzer, MD, a pediatric neurologist at University Hospitals Rainbow Babies & Children's Hospitals about the Center for Disease Control's estimate 10,000 toddlers receive medication for attention-deficit/hyperactivity disorder (ADHD).

31 May 2014

CMS says it won't review billings despite IG report that it overpays doctors

The move comes even as a report points at $6.7 billion in overspending in Medicare. The HHS inspector general also says that the program paid $457 million in 2012 to detect drugs after a sharp increase in prescription drug abuse.

31 May 2014

Compound in saliva and proteins in blood may protect human cells from powerful toxins in tea, coffee

A compound in saliva, along with common proteins in blood and muscle, may protect human cells from powerful toxins in tea, coffee and liquid smoke flavoring, according to results of a new study led by investigators at the Johns Hopkins Kimmel Cancer Center.

31 May 2014

Medtronic settles whistleblower case for $9.9 million

Suit accused the medical device maker of giving doctors gifts in return for using its products. Elsewhere, a federal judge denied dismissal of a lawsuit against Novartis alleging a kickback campaign to boost its drugs covered by Medicare and Medicaid.

31 May 2014

Researchers make headway in fabricating blood vessels using 3D bioprinting technique

The tangled highway of blood vessels that twists and turns inside our bodies, delivering essential nutrients and disposing of hazardous waste to keep our organs working properly has been a conundrum for scientists trying to make artificial vessels from scratch.

31 May 2014

Women with metastatic breast cancer can receive bisphosphonates less frequently and safely

Women with metastatic breast cancer to the bone may be able to receive bisphosphonates, the bone-targeting class of drugs like zoledronic acid, less often after the first year of monthly administration.

31 May 2014

Discontinuing statins in patients with advanced illnesses improves quality of life

People in the late stages of cancer and other terminal illnesses are not only unharmed by discontinuing statins for cholesterol management, they may benefit, according to a study presented Friday by researchers at Duke Medicine representing a national research network.

31 May 2014

DNA-binding fluorescent dyes evaluate cytotoxicity in real-time during screening

High throughput screening of compounds in live cells is a powerful approach for discovering new drugs, but the potential for cell toxicity must be considered.

31 May 2014

First Edition: May 30, 2014

Today's headlines include the latest reports about the problems with the VA health system. Kaiser Health News staff writer Julie Rovner reports: "It's not just veterans who are having trouble with health care.

30 May 2014

Newron Pharmaceuticals submits safinamide NDA to FDA

Newron Pharmaceuticals S.p.A. ("Newron"), a research and development company focused on novel CNS and pain therapies, and its partner Zambon S.p.A., an international pharmaceutical company strongly committed to the CNS therapeutic area with a long experience in respiratory disease therapies, woman care and primary care, announce that the New Drug Application (NDA) for safinamide was submitted today to the US Food and Drug Administration (FDA).

30 May 2014

Genzyme: FDA accepts resubmission of Lemtrada sBLA

Genzyme, a Sanofi company, announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the company's resubmission of its supplemental Biologics License Application (sBLA) seeking approval of LemtradaTM (alemtuzumab) for the treatment of relapsing forms of multiple sclerosis.

30 May 2014

Viewpoints: Michelle Obama and school lunches; more about the VA health system 'scandal'; context and caution on Medicare's physician data release

When we began our Let's Move! initiative four years ago, we set one simple but ambitious goal: to end the epidemic of childhood obesity in a generation so that kids born today will grow up healthy.

30 May 2014

Perelman School wins $10M renewal to study oldest part of human immune system

The National Institute of Allergy and Infectious Diseases has awarded the Perelman School of Medicine at the University of Pennsylvania a five-year, $10 million renewal of a program project to study the oldest part of the human immune system called the complement system, or simply "complement."

30 May 2014

Review on effects of pre-referral rectal artesunate for people with severe malaria

Researchers from the Cochrane Infectious Diseases Group, hosted at LSTM, conducted an independent review of the effects of pre-referral rectal artesunate for people with severe malaria, published in the Cochrane Library today.

30 May 2014

Researchers identify new therapeutic target for treating most common form of eye cancer

Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with mice, been able to slow eye tumor growth with an existing FDA-approved drug.

30 May 2014

Transplantation of embryonic neural cells can alleviate epilepsy seizure activity in mice

New research from North Carolina State University pinpoints the areas of the cerebral cortex that are affected in mice with absence epilepsy and shows that transplanting embryonic neural cells into these areas can alleviate symptoms of the disease by reducing seizure activity.

30 May 2014

Drugs News and Research

Agena Bioscience expands ultrasensitive somatic mutation detection technology

Health advocates allege 4 Fla. insurers discriminate against HIV patients

FDA grants Angiochem’s ANG1005 fast track and orphan drug designation for treatment of glioblastoma multiforme

Angiochem commences ANG1005 Phase 2 clinical study in HER2+ breast cancer patients with brain metastases

10,000 toddlers receive medication for ADHD, shows report

CMS says it won't review billings despite IG report that it overpays doctors

Compound in saliva and proteins in blood may protect human cells from powerful toxins in tea, coffee

Medtronic settles whistleblower case for $9.9 million

Researchers make headway in fabricating blood vessels using 3D bioprinting technique

Women with metastatic breast cancer can receive bisphosphonates less frequently and safely

Discontinuing statins in patients with advanced illnesses improves quality of life

DNA-binding fluorescent dyes evaluate cytotoxicity in real-time during screening

First Edition: May 30, 2014

Newron Pharmaceuticals submits safinamide NDA to FDA

Genzyme: FDA accepts resubmission of Lemtrada sBLA

Viewpoints: Michelle Obama and school lunches; more about the VA health system 'scandal'; context and caution on Medicare's physician data release

Perelman School wins $10M renewal to study oldest part of human immune system

Review on effects of pre-referral rectal artesunate for people with severe malaria

Researchers identify new therapeutic target for treating most common form of eye cancer

Transplantation of embryonic neural cells can alleviate epilepsy seizure activity in mice

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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