Protein C News and Research

RSS

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

CIP2A pathway involved in erlotinib response

Researchers have identified a novel mechanism, involving the cancerous inhibitor of protein phosphatase 2A pathway, which mediates the anti-tumour effects of erlotinib in non-small-cell lung cancer cells without epidermal growth factor receptor mutations.

16 Jul 2014

Scientists build artificial cells programmed to eat their undesirable neighbors

A team of researchers has devised a Pac-Man-style power pellet that gets normally mild-mannered cells to gobble up their undesirable neighbors. The development may point the way to therapies that enlist patients’ own cells to better fend off infection and even cancer, the researchers say. A description of the work will be published July 15 in the journal Science Signaling.

16 Jul 2014

Thirteen scientists receive grant to identify new treatments, cure for psoriasis

Thirteen scientists received a total of $1.05 million in funding from the National Psoriasis Foundation for projects that aim to identify new treatments and a cure for psoriasis—an autoimmune disease that appears on the skin, affecting 7.5 million Americans—and psoriatic arthritis—an inflammatory arthritis that affects the joints and tendons, occurring in up to 30 percent of people with psoriasis.

16 Jul 2014

Research sheds light on key mechanism prevalent in Alzheimer's disease patients

Alzheimer's disease affects approximately 5.2 million people in the United States alone, and it is the nation's sixth leading cause of death.

16 Jul 2014

New self-assembling nanoparticle helps doctors diagnose cancer earlier

Scientists have designed a new self-assembling nanoparticle that targets tumours, to help doctors diagnose cancer earlier.

16 Jul 2014

Biochemists find groups of tiny protein loops that help bacteria to establish infection

When it comes to infecting humans and animals, bacteria need a helping hand. Kansas State University biochemists have found the helping hand: groups of tiny protein loops on the surface of cells.

16 Jul 2014

USAMRIID provides on-site laboratory support to current Ebola outbreak

Analysis of clinical samples from suspected Lassa fever cases in Sierra Leone showed that about two-thirds of the patients had been exposed to other emerging diseases, and nearly nine percent tested positive for Ebola virus.

16 Jul 2014

Health concerns over arsenic in rice-especially for children

Inorganic arsenic in rice and rice-based foods poses health concerns in infants and young children, and steps should be taken to minimize exposure, according to a commentary in the Journal of Pediatric Gastroenterology and Nutrition, official journal of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.

16 Jul 2014

Researchers reveal molecular interplay between Roquin and RNA

The Roquin protein, discovered in 2005, controls T-cell activation and differentiation by regulating the expression of certain mRNAs. In doing so, it helps to guarantee immunological tolerance and prevents immune responses against the body's own structures that can lead to autoimmune disease.

16 Jul 2014

Research sheds new light on brain's complicated barrier tissue

Research from the University of Copenhagen is shedding new light on the brain's complicated barrier tissue. The blood-brain barrier is an effective barrier which protects the brain, but which at the same time makes it difficult to treat diseases such as Alzheimer's.

16 Jul 2014

New tools for detecting and monitoring TB in captive elephants

Mycobacterium tuberculosis, the organism that causes tuberculosis in humans, also afflicts Asian (and occasionally other) elephants. Diagnosing and treating elephants with TB is a challenge, however, as little is known about how their immune systems respond to the infection.

16 Jul 2014

Neuroprotective effects of ginsenoside Rb1 on hippocampal neuronal injury, neurite outgrowth

The main pathological changes of Alzheimer's disease (AD) include amyloid-beta protein-induced hippocampal neuronal injury and neurite outgrowth impairment.

15 Jul 2014

Pfizer to in-license Absorption Systems' BCRP-MDCK cells

Absorption Systems, a leader in novel test systems for drug transporters, announces a license agreement with Pfizer Inc., in which Pfizer will in-license Absorption Systems' BCRP-MDCK cells. This cell line is stably transfected with the human ABCG2 gene, which codes for a protein known as BCRP (breast cancer resistance protein).

15 Jul 2014

New role for cholesterol in activation of cellular signaling pathway that linked to cancer

Everyone knows that cholesterol, at least the bad kind, can cause heart disease and hardening of the arteries. Now, researchers at the University of Illinois at Chicago describe a new role for cholesterol in the activation of a cellular signaling pathway that has been linked to cancer.

15 Jul 2014

Interaction between 2 proteins can be responsible for allergic asthma after eating infected fruit

Researchers at the UPM suggest that the interaction between two proteins can be the responsible for the allergic asthma episodes after eating an infected fruit.

15 Jul 2014

DARPins could revolutionize protein therapeutics

Integrating an INTEGRA VIAFLO 96 multichannel pipette into their high throughput expression facility has enabled Molecular Partners (Zurich, Switzerland) to streamline the discovery and development of a novel class of targeted protein therapeutics termed DARPins.

From INTEGRA Biosciences 15 Jul 2014

New potential avenues to predict and prevent ovarian cancer metastasis

Circulating tumor cells spread ovarian cancer through the bloodstream, homing in on a sheath of abdominal fatty tissue where it can grow and metastasize to other organs, scientists at The University of Texas MD Anderson Cancer Center report in Cancer Cell.

15 Jul 2014

BAI and Novartis determine whether investigational drugs can prevent symptoms of Alzheimer's

Researchers from the Banner Alzheimer's Institute (BAI) today announced a partnership with Novartis in a pioneering medical trial to determine whether two investigational anti-amyloid drugs-an active immunotherapy and an oral medication-can prevent or delay the emergence of symptoms of Alzheimer's in people at particularly high risk for developing the disease at older ages.

15 Jul 2014

Acute glaucoma is largely an inflammatory disease, say researchers

Researchers at the University of California, San Diego School of Medicine and Sun Yat-sen University in China have shown that acute glaucoma in mice is largely an inflammatory disease and that high pressure in the eye causes vision loss by setting in motion an inflammatory response similar to that evoked by bacterial infections.

14 Jul 2014