Central Nervous System News and Research

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Investigators find potential new target for treatment of low-grade gliomas

Investigators at Johns Hopkins have found a known genetic pathway to be active in many difficult-to-treat pediatric brain tumors called low-grade gliomas, potentially offering a new target for the treatment of these cancers.

7 Nov 2013

Depomed reports financial results for third quarter 2013

Total revenues were $37.5 million and included recognition of a $5.0 million milestone payment from Mallinckrodt related to the NDA filing of MNK-795. Excluding this milestone and a $10 million upfront payment from Janssen in the third quarter of 2012, total revenues of $32.5 million grew 39% compared to $23.3 million for the third quarter of 2012.

6 Nov 2013

Research: Chronic stress changes gene activity in immune cells before reaching bloodstream

New research shows that chronic stress changes gene activity in immune cells before they reach the bloodstream. With these changes, the cells are primed to fight an infection or trauma that doesn't actually exist, leading to an overabundance of the inflammation that is linked to many health problems.

6 Nov 2013

Disruption of brain signals contributes to increased pain sensitivity in fibromyalgia patients

New research indicates that a disruption of brain signals for reward and punishment contributes to increased pain sensitivity, known as hyperalgesia, in fibromyalgia patients. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggest that this altered brain processing might contribute to widespread pain and lack of response to opioid therapy in patients with fibromyalgia.

5 Nov 2013

Alkermes reports 38% of year-over-year revenue growth from key products

Alkermes plc today reported financial results for the quarter ended Sept. 30, 2013. This is the second quarter of the nine-month period ending Dec. 31, 2013, as the company transitions to reporting on a calendar year basis.

31 Oct 2013

Whitehead Institute scientists identify novel Parkinson's disease drug target

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

25 Oct 2013

Type 1 diabetes modifies communication between central nervous system and bone marrow

A new University of Sydney study has found that having Type 1 diabetes alters the normal communication between the human central nervous system and bone marrow, causing inflammatory effects and further disease.

24 Oct 2013

Case Western oral pain expert encourages people with persistent mouth pain to check for BMS

Oral pain that feels like a scalded mouth and can last for months has baffled dental researchers since the 1970s, when burning oral sensations were linked to mucosal, periodontal, and restorative disorders and mental or emotional causes.

24 Oct 2013

Researchers improve cytostatic therapy for children with chronic immune deficiency disorder

Researchers at Karolinska Institutet in Sweden, and colleagues at University Children's Hospital Z-rich in Switzerland have managed to improve cytostatic therapy for children with the chronic immune deficiency disorder granulomatous disease prior to stem cell transplantation.

24 Oct 2013

WHO calls on countries to eliminate lead poisoning that affects children globally

Lead poisoning has devastating health consequences, in particular for children, with childhood lead exposure estimated to contribute to 600 000 new cases of children with intellectual disabilities every year. Overall, 99% of children affected by high exposure to lead live in low- and middle-income countries, says WHO on the occasion of International Lead Poisoning Prevention Week of Action, and calls on countries to strengthen national actions to eliminate lead paint.

18 Oct 2013

Scientists identify recessive gene mutation that reduces certain protein affecting brain development

Though worlds apart, four unrelated families have been united in a medical mystery over the source of a rare inherited disorder that results in their children being born with abnormal brain growth and severe functional impairments.

17 Oct 2013

Loyola University MNSON receives two grants to foster education, meet health needs of community

Loyola University Chicago Marcella Niehoff School of Nursing (MNSON) has received two grants from the Health Resources and Services Administration (HRSA) to foster interprofessional education and collaboration to better meet the health needs of the community.

17 Oct 2013

Research in mouse whiskers reveals signal pathway from touch neuron to brain

Human fingertips have several types of sensory neurons that are responsible for relaying touch signals to the central nervous system. Scientists have long believed these neurons followed a linear path to the brain with a "labeled-lines" structure.

17 Oct 2013

SAGE Therapeutics obtains $20M Series B financing from two investors

SAGE Therapeutics, a biopharmaceutical company developing novel medicines to treat central nervous system (CNS) diseases, today announced a $20 million Series B financing from investors ARCH Venture Partners and Third Rock Ventures, bringing the total raised to $57.8 million since launch in 2011.

16 Oct 2013

Modeling, identifying predictors of Parkinson's disease with stem cells

The New York Stem Cell Foundation Research Institute has entered into a partnership with the Parkinson's Progression Markers Initiative to build resources for studying Parkinson's disease to accelerate new treatments. Sponsored by The Michael J. Fox Foundation for Parkinson's Research, PPMI is a landmark effort to identify and validate biomarkers of Parkinson's disease.

15 Oct 2013

High doses of ADHD drugs may be effective for people with amphetamine dependency

People with ADHD and dependency rarely respond as they should to ADHD drugs. A randomised study from Karolinska Institutet in Sweden now shows that it is possible to obtain the desired efficacy by administering the drug in higher doses.

15 Oct 2013

IV lidocaine infusion provides significant pain relief to fibromyalgia patients

Patients with fibromyalgia resistant to more routine therapies have a new pain relief treatment available, according to a study presented at the ANESTHESIOLOGY 2013 annual meeting.

14 Oct 2013

NIH selects Salk scientist for EUREKA grant

The National Institutes of Health has selected Axel Nimmerjahn for a highly competitive EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) grant. Dr. Nimmerjahn is an Assistant Professor in the Waitt Advanced Biophotonics Center and holds the Richard Allan Barry Developmental Chair.

13 Oct 2013

Diverse Neurological Disorders Appear To Share Tangled Metabolic Roots

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10 Oct 2013

Gene mutation offers clues to development of diverse neurological disorders

A research team, headed by Theodore Friedmann, MD, professor of pediatrics at the University of California, San Diego School of Medicine, says a gene mutation that causes a rare but devastating neurological disorder known as Lesch-Nyhan syndrome appears to offer clues to the developmental and neuronal defects found in other, diverse neurological disorders like Alzheimer's, Parkinson's and Huntington's diseases.

10 Oct 2013

Central Nervous System News and Research

Investigators find potential new target for treatment of low-grade gliomas

Depomed reports financial results for third quarter 2013

Research: Chronic stress changes gene activity in immune cells before reaching bloodstream

Disruption of brain signals contributes to increased pain sensitivity in fibromyalgia patients

Alkermes reports 38% of year-over-year revenue growth from key products

Whitehead Institute scientists identify novel Parkinson's disease drug target

Type 1 diabetes modifies communication between central nervous system and bone marrow

Case Western oral pain expert encourages people with persistent mouth pain to check for BMS

Researchers improve cytostatic therapy for children with chronic immune deficiency disorder

WHO calls on countries to eliminate lead poisoning that affects children globally

Scientists identify recessive gene mutation that reduces certain protein affecting brain development

Loyola University MNSON receives two grants to foster education, meet health needs of community

Research in mouse whiskers reveals signal pathway from touch neuron to brain

SAGE Therapeutics obtains $20M Series B financing from two investors

Modeling, identifying predictors of Parkinson's disease with stem cells

High doses of ADHD drugs may be effective for people with amphetamine dependency

IV lidocaine infusion provides significant pain relief to fibromyalgia patients

NIH selects Salk scientist for EUREKA grant

Diverse Neurological Disorders Appear To Share Tangled Metabolic Roots

Gene mutation offers clues to development of diverse neurological disorders

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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