Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Judge's second ruling on child transplants prompts ethical, political questions

A federal judge issued a second ruling in as many days allowing another dying child onto an adult transplant list -- a move that could have ramifications for thousands of adults waiting for donated organs.

10 Jun 2013

Judge orders Sebelius to put girl who needs lung on transplant list

A federal judge intervened in the case of a 10-year-old girl with cystic fibrosis who needs a lung transplant, ordering HHS Secretary Kathleen Sebelius to provide an exception and place the girl on the adult lung transplant list.

7 Jun 2013

Lawmakers 'beg' Sebelius for child's lung transplant

A 10-year-old girl in urgent need of a transplant was brought up by some GOP lawmakers during Health and Human Services Secretary Kathleen Sebelius' appearance at a House hearing.

6 Jun 2013

RXi Pharmaceuticals reports positive results from 2 placebo-controlled double blind studies of RXI-109

RXi Pharmaceuticals Corporation, a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using RNA-targeted technologies, today announced the unblinded results of the first of their 2 placebo-controlled double blind studies in volunteers with their anti-scarring agent RXI-109, a proprietary sd-rxRNA compound that has been shown in vitro and in animals to reduce mRNA for connective tissue growth factor.

6 Jun 2013

Researchers demonstrate how modified citrus pectin works against cancer

A new review by researchers at the University of Maryland School of Medicine highlights a large body of published research demonstrating how modified citrus pectin, works against cancer.

4 Jun 2013

Arcturus Therapeutics closes $1.3 M in seed funding round

Arcturus Therapeutics, Inc., an industry leader in RNAi technologies for the treatment of disease, today announced it has raised $1.3 million in a seed funding round led by multiple high net-worth private investors from the United States and Canada.

3 Jun 2013

Activ8rlives 2.0 goes live with new self monitoring capabilities for health and wellness

Activ8rlives’ website version 2.0 has now gone live after several months of preparation and testing. Activ8rlives focuses its online self monitoring solutions for health and wellness, which is utilized by families, groups and companies.

3 Jun 2013

CREON Delayed-Release Capsules now available in US for patients with EPI

AbbVie announced that a new, higher-dose capsule of CREON (pancrelipase) Delayed-Release Capsules is commercially available in the United States. The U.S. Food and Drug Administration recently approved CREON in a 36,000 lipase-unit dose to treat patients with exocrine pancreatic insufficiency due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

31 May 2013

Researchers develop new gene therapy to thwart potential influenza pandemic

Researchers at the Perelman School of Medicine, University of Pennsylvania have developed a new gene therapy to thwart a potential influenza pandemic. Specifically, investigators in the Gene Therapy Program, Department of Pathology and Laboratory Medicine, directed by James M. Wilson, MD, PhD, demonstrated that a single dose of an adeno-associated virus expressing a broadly neutralizing flu antibody into the nasal passages of mice and ferrets gives them complete protection and substantial reductions in flu replication when exposed to lethal strains of H5N1 and H1N1 flu virus.

30 May 2013

Scientists discover new function of an enzyme that disposes of superfluous proteins

Cells have a sophisticated system to control and dispose of defective, superfluous proteins and thus to prevent damage to the body. Dr. Katrin Bagola and Professor Thomas Sommer of the Max Delbr-ck Center for Molecular Medicine Berlin-Buch as well as Professor Michael Glickman and Professor Aaron Ciechanover of Technion, the Technical University of Israel in Haifa, have now discovered a new function of an enzyme that is involved in this vital process.

29 May 2013

Innovative nebulizer to treat cystic fibrosis developed by Cambridge Consultants

Observing surfers with cystic fibrosis (CF) led scientists to discover that the inhaled mist of seawater has a therapeutic effect on the lung problems associated with the disease. Now the findings have been used by pharmaceutical company Parion Sciences and product development firm Cambridge Consultants in a revolutionary new aerosol delivery system. It enables CF sufferers to get the benefits of saltwater treatment in their own homes overnight while they sleep.

23 May 2013

MUC5B gene variation improves survival in patients with idiopathic pulmonary fibrosis

Variation in the gene MUC5B among patients with idiopathic pulmonary fibrosis was associated with improved survival, according to a study published online by JAMA. The study is being released early online to coincide with its presentation at the American Thoracic Society international conference.

22 May 2013

Genetic risk factor for pulmonary fibrosis can be used to identify individuals at risk for lung disease

A paper recently published in the New England Journal of Medicine and co-written by physicians and scientists at the University of Colorado School of Medicine finds that an important genetic risk factor for pulmonary fibrosis can be used to identify individuals at risk for this deadly lung disease.

22 May 2013

Boehringer Ingelheim's tiotropium shows promising results in patients with severe persistent asthma

Boehringer Ingelheim today announced data from Phase 2 and Phase 3 studies from the Company's ongoing clinical trial program investigating the efficacy and safety of tiotropium in asthma. These data were presented at the American Thoracic Society International Conference in Philadelphia, Pennsylvania.

22 May 2013

Genetic variation helps predict survival in some cases of pulmonary fibrosis, study finds

Research into genetic features of pulmonary fibrosis by physicians and scientists at the University of Colorado School of Medicine may lead to improved treatment of this deadly lung disease, according to a paper published online by JAMA.

22 May 2013

Grifols signs worldwide licensing agreement for Aradigm's Pulmaquin

Grifols, S.A. and Aradigm Corporation today announced the signing of an exclusive, worldwide license for Aradigm's proprietary formulations of inhaled ciprofloxacin (Pulmaquin and Lipoquin) for the treatment of severe respiratory diseases, including non-cystic fibrosis bronchiectasis.

21 May 2013

Kidneys discarded for transplant can be used for manufacturing replacement organs, say researchers

Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too long without blood or oxygen. But, what if instead of being discarded, these organs could be "recycled" to help solve the critical shortage of donor organs?

21 May 2013

Researchers link coffee consumption with reduced risk of primary sclerosing cholangitis

Research presented today at Digestive Disease Week explores new discoveries in liver disease research, with findings about the impact of coffee on autoimmune disease and palliative care for cirrhotic patients.

20 May 2013

Boehringer Ingelheim to highlight respiratory research work at ATS 2013

Boehringer Ingelheim will contribute to advancing the scientific discussion in respiratory disease at the American Thoracic Society International Conference in Philadelphia, PA, May 17 – 22.

20 May 2013

Study: VEGF inhibitor appears to improve glaucoma surgical outcomes

The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial growth factor (VEGF) activates fibrosis, whereas VEGF inhibition results in reduced scar formation and better surgical results.

18 May 2013

Fibrosis News and Research

Further Reading

Judge's second ruling on child transplants prompts ethical, political questions

Judge orders Sebelius to put girl who needs lung on transplant list

Lawmakers 'beg' Sebelius for child's lung transplant

RXi Pharmaceuticals reports positive results from 2 placebo-controlled double blind studies of RXI-109

Researchers demonstrate how modified citrus pectin works against cancer

Arcturus Therapeutics closes $1.3 M in seed funding round

Activ8rlives 2.0 goes live with new self monitoring capabilities for health and wellness

CREON Delayed-Release Capsules now available in US for patients with EPI

Researchers develop new gene therapy to thwart potential influenza pandemic

Scientists discover new function of an enzyme that disposes of superfluous proteins

Innovative nebulizer to treat cystic fibrosis developed by Cambridge Consultants

MUC5B gene variation improves survival in patients with idiopathic pulmonary fibrosis

Genetic risk factor for pulmonary fibrosis can be used to identify individuals at risk for lung disease

Boehringer Ingelheim's tiotropium shows promising results in patients with severe persistent asthma

Genetic variation helps predict survival in some cases of pulmonary fibrosis, study finds

Grifols signs worldwide licensing agreement for Aradigm's Pulmaquin

Kidneys discarded for transplant can be used for manufacturing replacement organs, say researchers

Researchers link coffee consumption with reduced risk of primary sclerosing cholangitis

Boehringer Ingelheim to highlight respiratory research work at ATS 2013

Study: VEGF inhibitor appears to improve glaucoma surgical outcomes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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