Genes News and Research

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Needling chromosomes yields insights into cell division

By impaling individual chromosomes with glass needles one thousandth the diameter of a human hair, a Duke University graduate student has tested their "stickiness" to one another during cell division. Her uncanny surgical skills have added a piece to the large and intricate puzzle of how one cell divides into two -- a process fundamental to all organisms.

23 Dec 2004

Somatic hypermutation (SHM) should prove to be extremely useful in directed protein evolution

Fascinated by the efficient way the human immune system generates a rapid response to create a near-infinite variety of antibodies, researchers have "hijacked" that machinery and used it to evolve a new type of fluorescent protein.

23 Dec 2004

Researchers can now inexpensively program the chemical synthesis of entire genes on a single microchip

Devices the size of a pager now have greater capabilities than computers that once occupied an entire room. Similar advances are being made in the emerging field of synthetic biology at the University of Houston, now allowing researchers to inexpensively program the chemical synthesis of entire genes on a single microchip.

23 Dec 2004

Fluorescent colors used to separate cells visually

The latest holiday gifts being offered to the scientific community this season by scientists in the laboratory of Howard Hughes Medical Institute investigator Roger Y. Tsien come in a dazzling variety of hues -- cherry, strawberry, tangerine, tomato, orange, banana and honeydew. The color spectrum would make Pantone proud.

22 Dec 2004

Drinking water with high levels of arsenic increases risk of lung cancer

Residents of Taiwan who consumed drinking water with high levels of arsenic have a higher risk of lung cancer, with cigarette smokers from this group having an even greater risk, according to a study in the December 22/29 issue of JAMA.

22 Dec 2004

Jumping genes help explain immune system's remarkable ability

A team led by Johns Hopkins scientists has found the first clear evidence that the process behind the human immune system's remarkable ability to recognize and respond to a million different proteins might have originated from a family of genes whose only apparent function is to jump around in genetic material.

22 Dec 2004

Botox may be a possible treatment for sufferers of Tourette's syndrome

Researchers at Baylor College of Medicine in Houston are using botulinum toxin type A (Botox) to treat the neurological disorder, which can cause involuntary motor and vocal tics.

21 Dec 2004

Customising cancer treatment

At the Norwegian Radium Hospital in Oslo, scientists are approaching methods that will improve the patients' chances of survival and reduce unnecessary treatment.

21 Dec 2004

Certain leukemia oncogenes switch on genetic programs that govern self-renewal, a unique stem cell characteristic

Researchers have discovered that specific cancer-causing genes associated with leukemias can transform mature white blood cells into leukemic cells that have all the properties of stem cells.

21 Dec 2004

Mutant gene that starves the brain of serotonin 10 times more prevalent in depressed patients

A mutant gene that starves the brain of serotonin, a mood-regulating chemical messenger, has been discovered and found to be 10 times more prevalent in depressed patients than in control subjects, report researchers funded by the National Institutes of Health’s National Institute of Mental Health (NIMH) and National Heart Lung and Blood Institute (NHLBI).

21 Dec 2004

Major step forward in using saliva to detect oral cancer

Scientists funded by the National Institute of Dental and Craniofacial Research reported taking a major step forward in using saliva to detect oral cancer.

21 Dec 2004

Blocking gene's activity may control deadly skin cancer without harming normal cells

Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston have discovered that malignant melanoma, the potentially lethal skin cancer, can't grow without a steady supply of a protein that normal cells can do without.

20 Dec 2004

DLX5 gene may play a role in the pathology of Rett Syndrome

A research team led by Terumi Kohwi-Shigematsu of the Life Sciences Division of Lawrence Berkeley National Laboratory has identified a gene, DLX5, that may play a role in the pathology of Rett Syndrome, a devastating neurological disorder diagnosed almost exclusively in girls.

20 Dec 2004

Messenger RNA not only are measurable in saliva but can indicate a developing tumor

Scientists funded by the National Institute of Dental and Craniofacial Research reported today taking a major step forward in using saliva to detect oral cancer.

20 Dec 2004

Gene expression analysis software

Case Western Reserve University has announced that its BAMarray™ software is now available for download and licensing. The statistical software analyzes gene expression data -- one of the hottest areas of biology research.

20 Dec 2004

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

Sometime between the age of 6 and 18 months, after a period of seemingly normal development, girls affected with Rett Syndrome lose interest in play; they gradually become withdrawn and anxious, develop autistic-like behaviors, and acquire specific symptoms like repetitive teeth-grinding and hand-wringing.

20 Dec 2004

New theory driving evolutionary changes

Researchers at UT Southwestern Medical Center at Dallas have used canine DNA to identify a genetic mutation mechanism they believe is responsible for rapid evolutionary changes in the physical appearance of many species.

14 Dec 2004

New cancer detection technology from Rubicon Genomics

Rubicon Genomics has invented a more effective technology for the diagnosis and prognosis of cancer compared to what hospitals and reference laboratories use today. MethylPlex™ is the most sensitive method in use to detect the patterns of abnormal DNA methylation arising in the serum and urine of patients during tumor formation and progression.

14 Dec 2004

Landmark studies that may change the treatment standards for breast cancer

The 27th Annual San Antonio Breast Cancer Symposium that took place December 8-11 included the presentation of several landmark studies that may change the treatment standards for breast cancer.

14 Dec 2004

Instead of chemotherapy, drugs that influence the X protein's behavior might become an alternative cancer therapy

Identifying the link between chronic hepatitis B infection and liver cancer may one day help cancer patients sidestep the poison of chemotherapy, a Purdue University study suggests.

13 Dec 2004

Genes News and Research

Needling chromosomes yields insights into cell division

Somatic hypermutation (SHM) should prove to be extremely useful in directed protein evolution

Researchers can now inexpensively program the chemical synthesis of entire genes on a single microchip

Fluorescent colors used to separate cells visually

Drinking water with high levels of arsenic increases risk of lung cancer

Jumping genes help explain immune system's remarkable ability

Botox may be a possible treatment for sufferers of Tourette's syndrome

Customising cancer treatment

Certain leukemia oncogenes switch on genetic programs that govern self-renewal, a unique stem cell characteristic

Mutant gene that starves the brain of serotonin 10 times more prevalent in depressed patients

Major step forward in using saliva to detect oral cancer

Blocking gene's activity may control deadly skin cancer without harming normal cells

DLX5 gene may play a role in the pathology of Rett Syndrome

Messenger RNA not only are measurable in saliva but can indicate a developing tumor

Gene expression analysis software

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

New theory driving evolutionary changes

New cancer detection technology from Rubicon Genomics

Landmark studies that may change the treatment standards for breast cancer

Instead of chemotherapy, drugs that influence the X protein's behavior might become an alternative cancer therapy

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