Cell Death News and Research

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Study demonstrates effectiveness of new approach to protect humans from infectious disease

There are two common approaches to protecting humans from infectious disease: Targeting pathogens and parasites with medicines like antibiotics, or dealing with the conditions that allow transmission.

8 Sep 2015

New study reveals pivotal role of miR-506 biomarker in gastric cancer

Gastric cancer poses a significant health problem in developing countries and is typically associated with late-stage diagnosis and high mortality. A new study in The American Journal of Pathology points to a pivotal role played by the biomarker microRNA (miR)-506 in gastric cancer.

8 Sep 2015

Repeated exposure to anesthesia early in life causes long-term behavioral changes

Repeated exposure to anesthesia early in life causes alterations in emotional behavior that may persist long-term, according to a study from the Icahn School of Medicine at Mount Sinai in collaboration with the Yerkes National Primate Research Center, and published in the Online First edition of Anesthesiology, the official medical journal of the American Society of Anesthesiologists.

4 Sep 2015

Imetelstat drug shows promise in treating patients with myelofibrosis

Imetelstat, a novel drug that targets telomerase, has demonstrated potential value in treating patients with myelofibrosis, according to the results of a study published today in the New England Journal of Medicine.

3 Sep 2015

Diabetes may be linked to buildup of brain tangles associated with Alzheimer’s disease

Diabetes may be linked to the buildup of tangles or tau in the brain, separate from Alzheimer's disease, according to a new study published in the September 2, 2015, online version of Neurology, the medical journal of the American Academy of Neurology.

3 Sep 2015

TMIGD1 protein could be a novel target for restoring kidney function from kidney disease

A new discovery by Boston University School of Medicine (BUSM) researchers may change how kidney disease is treated in the future.

3 Sep 2015

Common antidepressant can help stroke patients improve movement and coordination

Working with mice, researchers at Johns Hopkins have added to evidence that a commonly prescribed antidepressant called fluoxetine helps stroke victims improve movement and coordination, and possibly why.

2 Sep 2015

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

A study published in The Journal of Cell Biology describes a way to force cancer cells to destroy a key metabolic enzyme they need to survive.

1 Sep 2015

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Viruses are able to redirect the functioning of cells in order to infect them. Inspired by their mode of action, scientists from the CNRS and Université de Strasbourg have designed a "chemical virus" that can cross the double lipid layer that surrounds cells, and then disintegrate in the intracellular medium in order to release active compounds.

29 Aug 2015

Cell-to-cell transmission of HIV leads to development of AIDS

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another.

28 Aug 2015

Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

The death of brain cells in Parkinson's disease may be caused by a form of cellular energy crisis in neurons that require unusually high quantities of energy to carry out their job of regulating movement, researchers at the University of Montreal reported today.

28 Aug 2015

Discovery could help in development of novel cancer-selective viral therapies

Every organism--from a seedling to a president--must protect its DNA at all costs, but precisely how a cell distinguishes between damage to its own DNA and the foreign DNA of an invading virus has remained a mystery.

27 Aug 2015

Common gene mutation may cause brain damage associated with ALS and FTD

Johns Hopkins researchers say they have discovered some of the first steps in how a very common gene mutation causes the brain damage associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

27 Aug 2015

Irreversible electroporation may prolong survival rates of patients with locally advanced pancreatic cancer

Use of irreversible electroporation (IRE) doubles the survival time for patients with locally advanced pancreatic cancer say researchers at the University of Louisville in a paper in the September edition of the Annals of Surgery.

25 Aug 2015

Researchers report new breakthrough in countering deadly effects of radiation exposure

An interdisciplinary research team led by The University of Texas Medical Branch at Galveston reports a new breakthrough in countering the deadly effects of radiation exposure. A single injection of a regenerative peptide was shown to significantly increase survival in mice when given 24 hours after nuclear radiation exposure.

24 Aug 2015

PHD1 inhibition may have therapeutic potential for colorectal cancer

Scientists at VIB and KU Leuven have shown that blocking the PHD1 oxygen sensor hinders the activation of p53, a transcription factor that aids colorectal cancer (CRC) cells in repairing themselves and thus resisting chemotherapy. Chemotherapy resistance remains a major clinical issue in the treatment of CRC. These findings indicate that PHD1 inhibition may have valuable therapeutic potential. The study was published in the leading medical journal EMBO Molecular Medicine, which features molecular biology-driven research.

19 Aug 2015

3D protein structure reveals new drug targets for cancer, neurodegenerative diseases

Protein Kinase C (PKC) is a family of enzymes that controls the activity of other proteins in a cell by attaching chemical tags. That simple act helps determine cell survival or death.

14 Aug 2015

Study suggests potential target for treating familial form of ALS

A healthy motor neuron needs to transport its damaged components from the nerve-muscle connection all the way back to the cell body in the spinal cord. If it cannot, the defective components pile up and the cell becomes sick and dies. Researchers at the NIH's National Institute of Neurological Disorders and Stroke have learned how a mutation in the gene for superoxide dismutase 1 (SOD1), which causes ALS, leads cells to accumulate damaged materials.

13 Aug 2015

Researchers report role of two gene-regulating molecules in Parkinson's disease

As Parkinson's disease progresses in patients, a puzzling dichotomy plays out in their brains. One set of neurons degenerates, while a similar population nearby is spared the same degree of damage. Why the difference? An answer to this question could clear the way for preventions and treatments for this disease, which impairs movement.

11 Aug 2015

Findings by Joslin scientists may lead to early detection, treatment of complications in type 1 diabetes

Joslin scientists have advanced understanding of how the cellular repair process is impaired in type 1 diabetes, which can cause cell death and lead to complications. The findings appear in the August issue of Cell Metabolism.

5 Aug 2015

Cell Death News and Research

Study demonstrates effectiveness of new approach to protect humans from infectious disease

New study reveals pivotal role of miR-506 biomarker in gastric cancer

Repeated exposure to anesthesia early in life causes long-term behavioral changes

Imetelstat drug shows promise in treating patients with myelofibrosis

Diabetes may be linked to buildup of brain tangles associated with Alzheimer’s disease

TMIGD1 protein could be a novel target for restoring kidney function from kidney disease

Common antidepressant can help stroke patients improve movement and coordination

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Cell-to-cell transmission of HIV leads to development of AIDS

Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

Discovery could help in development of novel cancer-selective viral therapies

Common gene mutation may cause brain damage associated with ALS and FTD

Irreversible electroporation may prolong survival rates of patients with locally advanced pancreatic cancer

Researchers report new breakthrough in countering deadly effects of radiation exposure

PHD1 inhibition may have therapeutic potential for colorectal cancer

3D protein structure reveals new drug targets for cancer, neurodegenerative diseases

Study suggests potential target for treating familial form of ALS

Researchers report role of two gene-regulating molecules in Parkinson's disease

Findings by Joslin scientists may lead to early detection, treatment of complications in type 1 diabetes

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