Proliferation News and Research

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Modern day wearable technology may impact daily life, health care system

With the rapid proliferation of smart mobile devices, and the subsequent increase in data that is being gathered, the challenge is: how do we harness it?

26 May 2016

TSRI scientists discover new method for harnessing venoms for therapeutic use

There are lessons to be learned from venoms. Scorpions, snakes, snails, frogs and other creatures are thought to produce tens or even hundreds of millions of distinct venoms. These venoms have been honed to strike specific targets in the body.

26 May 2016

Common pain and anti-inflammation drugs may slow cancer growth

Scientists from the Florida campus of The Scripps Research Institute have found that one of the most widely prescribed pain and anti-inflammation drugs slows the growth rate of a specific kind of cancer in animal models and suggests the medication could have the same effect on other types of tumors.

26 May 2016

Combining vitamin A with chemotherapy may offer promise for pancreatic cancer treatment

Around 8,800 people in the UK are diagnosed with pancreatic cancer each year. It is known as the UK's deadliest cancer, with a survival rate of just 3 per cent. Chemotherapy and radiotherapy alone are relatively unsuccessful in treating the disease, and while surgery to remove the tumour offers the best chance of survival, most patients are diagnosed when the cancer has already spread to other organs.

25 May 2016

AKR1C3 enzyme could be promising therapeutic target for managing CRPC, AML

Prostate cancer is the second leading cause of mortality among American men with the highest incidence rate of all cancers reported in the U.S. Male sex hormones testosterone (T) and 5α-dihydrotestosterone (5α-DHT) promote prostate cancer progression.

19 May 2016

Flavopiridol drug could be effective strategy to impair brain cancer growth

Glioblastoma, the most common form of brain cancer is a deadly disease for which at present there is no cure. Now, researchers have published research results that show how repurposing the old drug flavopiridol could be an effective strategy to cut short sugar availability and impair cancer growth.

19 May 2016

Maintaining balance of P1 and P2 isoforms vital for reducing colon cancer, colitis risk

Inflammatory bowel disease (IBD), of which Crohn's disease and ulcerative colitis are the main types, is on the increase in the United States, affecting more than 1.6 million people and explaining perhaps the increase in advertisements offering treatments and cures.

18 May 2016

High levels of secretin hormone may play vital role in management of chronic liver diseases

High levels of a digestive hormone called secretin may play an important role in the management of certain chronic liver diseases, according to new research published in the journal Hepatology. These findings could result in new ways to treat cholestatic liver diseases, a condition that impairs the movement of bile, the fluid produced by the liver to digest fats.

18 May 2016

Targeting ERK and compensatory pathways with drug inhibitors halts colorectal cancer growth

While investigating a potential therapeutic target for the ERK1 and 2 pathway, a widely expressed signaling molecule known to drive cancer growth in one third of patients with colorectal cancer, University of California San Diego School of Medicine researchers found that an alternative pathway immediately emerges when ERK1/2 is halted, thus allowing tumor cell proliferation to continue.

18 May 2016

Biovica acquires cSens AB - creating opportunities for solving cancer diagnostic challenges

Biovica has acquired cSens AB, a company that has developed a PCR-based platform for the analysis of serum thymidine kinase (TK) enzyme activity, which correspond to tumor proliferation and cancer aggressiveness.

18 May 2016

Study shows inhibition of SHP-2 enzyme can diminish lupus symptoms

Researchers at Beth Israel Deaconess Medical Center have identified an enzyme that is significantly elevated in mouse models of systemic lupus erythematosus and in blood samples of patients with lupus.

17 May 2016

FDA approves additional indication for Eisai's anticancer agent Lenvima in combo with Everolimus for advanced renal cell carcinoma

Eisai Co., Ltd. has announced that its U.S. subsidiary Eisai Inc. has received approval from the U.S. Food and Drug Administration (FDA) for an additional indication for Eisai's in-house developed novel anticancer agent Lenvima (lenvatinib mesylate) in combination with everolimus for the treatment of patients with advanced renal cell carcinoma following one prior anti-angiogenic therapy.

16 May 2016

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations.

16 May 2016

Gene therapy shows promise in treating glioblastoma

A team from the International School for Advanced Studies in Trieste has obtained very promising results by applying gene therapy to glioblastoma.

13 May 2016

McGill researchers discover brain cells that play key role in leptin sensing, weight gain

It's rare for scientists to get what they describe as "clean" results without spending a lot of time repeating the same experiment over and over again. But when researchers saw the mice they were working with doubling their weight within a month or two, they knew they were on to something.

13 May 2016

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

The Medical University of South Carolina's Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers.

10 May 2016

Implication of microRNAs in cancer development greater than previously thought

Small, non-coding molecules called microRNAs are known to play an important role in cancer development. Researchers now have shown their significance is greater than previously thought, a finding that could lead to new therapeutic approaches for the most common and deadly form of ovarian cancer.

6 May 2016

Studies show mango consumption may contribute to protective health effects

Four new studies surrounding the effects of mango consumption suggest this superfruit has the potential to help combat adverse effects associated with high fat diets and obesity (animal study), as well inhibit growth of fat cells (anti-lipogenic properties in an in-vivo study), slow advancement of breast cancer tumors (animal study), as well as improve regularity and decrease inflammation associated with constipation (human subject study).

6 May 2016

Research provides new insight into cellular composition of IDH1-mutant gliomas

Winner of the Preuss Research Award, Andrew Venteicher, MD, PhD, presented his research, Cellular Architecture of Human IDH1-mutant Gliomas Revealed Using Single-cell RNA Sequencing, during the 2016 American Association of Neurological Surgeons Annual Scientific Meeting.

5 May 2016

Study reveals new cell-signaling pathway that detects chromosome missegregation

A recent research study at The Hormel Institute, University of Minnesota is providing insight into the regulation of chromosome segregation and the mechanisms used by cells to prevent them from forming tumors.

4 May 2016

Proliferation News and Research

Modern day wearable technology may impact daily life, health care system

TSRI scientists discover new method for harnessing venoms for therapeutic use

Common pain and anti-inflammation drugs may slow cancer growth

Combining vitamin A with chemotherapy may offer promise for pancreatic cancer treatment

AKR1C3 enzyme could be promising therapeutic target for managing CRPC, AML

Flavopiridol drug could be effective strategy to impair brain cancer growth

Maintaining balance of P1 and P2 isoforms vital for reducing colon cancer, colitis risk

High levels of secretin hormone may play vital role in management of chronic liver diseases

Targeting ERK and compensatory pathways with drug inhibitors halts colorectal cancer growth

Biovica acquires cSens AB - creating opportunities for solving cancer diagnostic challenges

Study shows inhibition of SHP-2 enzyme can diminish lupus symptoms

FDA approves additional indication for Eisai's anticancer agent Lenvima in combo with Everolimus for advanced renal cell carcinoma

Unlocking the dark proteome: an interview with Dr Kriwacki

Gene therapy shows promise in treating glioblastoma

McGill researchers discover brain cells that play key role in leptin sensing, weight gain

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

Implication of microRNAs in cancer development greater than previously thought

Studies show mango consumption may contribute to protective health effects

Research provides new insight into cellular composition of IDH1-mutant gliomas

Study reveals new cell-signaling pathway that detects chromosome missegregation

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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