Protein C News and Research

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Scientists uncover surprising link between brain development and gene tied to breast cancer

Scientists at the Salk Institute have uncovered details into a surprising-and crucial-link between brain development and a gene whose mutation is tied to breast and ovarian cancer.

9 Apr 2014

Study shows subpopulations of breast cancer cells cooperate to aid tumor growth

Subpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for cancer treatment.

9 Apr 2014

Production of Immutep’s ImmuFact IMP321 starts at WuXi AppTec facilities in China

Immutep S.A., the biopharmaceutical company specializing in immuno-oncology, and Eddingpharm have started production of Immutep’s ImmuFact IMP321 (a LAG-3Ig fusion protein) at WuXi AppTec facilities in China. The product is being produced to European, U.S. and Chinese GMP standards.

8 Apr 2014

Study: VISTA deficiency leads to enhanced immune activation

Researchers at the Geisel School of Medicine at Dartmouth have found that the body's immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting.

8 Apr 2014

PeptiDream develops novel macrocyclic peptide inhibitor for treatment of multiple influenza strains

PeptiDream Inc., a public Tokyo-based biopharmaceutical company ("PeptiDream")( TOKYO:4587) announced today, in collaboration with The Tokyo Metropolitan Institute of Medical Science ("Tokyo Metropolitan Institute") the discovery and development of a novel macrocyclic peptide inhibitor for the treatment of multiple influenza strains.

8 Apr 2014

Research to understand exactly how bleach kills bacteria

Spring cleaning often involves chlorine bleach, which has been used as a disinfectant for hundreds of years. But our bodies have been using bleach's active component, hypochlorous acid, to help clean house for millennia. As part of our natural response to infection, certain types of immune cells produce hypochlorous acid to help kill invading microbes, including bacteria.

8 Apr 2014

Researchers show Elafin protein plays key role against inflammatory reaction typical of celiac disease

Scientists from INRA and INSERM (France) in collaboration with scientists from McMaster University (Canada) and the Ecole polytechnique fédérale of Zurich (Switzerland) have shown that Elafin, a human protein, plays a key role against the inflammatory reaction typical of celiac disease (gluten intolerance).

8 Apr 2014

TSRI reveals new aspects of more potent anti-diabetic drugs with fewer serious side effects

8 Apr 2014

Magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment

In a presentation exploring the promise of magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment, Dartmouth researcher P. Jack Hoopes, DMV, PhD, reviewed preclinical studies conducted at Norris Cotton Cancer Center and discuss plans for early-phase clinical studies in humans at the annual meeting of the American Association for Cancer Research (AACR).

8 Apr 2014

NRAS gene that plays fundamental role in cancer development produces five gene variants, says study

A new study shows that a gene discovered 30 years ago and now known to play a fundamental role in cancer development produces five different gene variants (called isoforms), rather than just the one original form, as thought.

8 Apr 2014

Genome Project offers new leads to improve outcomes for children with high-grade glioma brain tumors

The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas (HGGs), which most often occur in the youngest patients.

8 Apr 2014

Findings could lead to more potent anti-diabetic drugs with fewer side effects

Scientists thought they basically knew how the most common drugs used to treat type 2 diabetes worked, but a new study from the Florida campus of The Scripps Research Institute (TSRI) reveals unexpected new aspects of the process. These findings could eventually lead to more potent anti-diabetic drugs with fewer serious side effects.

7 Apr 2014

UPCI/MWRI researchers to present results of immune gene profile exploring endometriosis and cancer

Some women with endometriosis, a chronic inflammatory disease, are predisposed to ovarian cancer, and a genetic screening might someday help reveal which women are most at risk, according to a University of Pittsburgh Cancer Institute (UPCI) study, in partnership with Magee-Womens Research Institute (MWRI).

7 Apr 2014

Caffeine has positive effect on tau deposits in Alzheimer's disease

As part of a German-French research project, a team led by Dr. Christa E. Müller from the University of Bonn and Dr. David Blum from the University of Lille was able to demonstrate for the first time that caffeine has a positive effect on tau deposits in Alzheimer's disease.

7 Apr 2014

TSRI scientists solve long-standing mystery about sense of touch

A study led by scientists at The Scripps Research Institute (TSRI) has helped solve a long-standing mystery about the sense of touch.

7 Apr 2014

New insights provide novel therapeutic approach against cancer

A major discovery that brings a new drug target to the increasingly exciting landscape of cancer immunotherapy was published yesterday by researchers from La Jolla Institute for Allergy and Immunology and their collaborators from other institutes.

7 Apr 2014

Compounds from plant confer protective effects against breast cancer, say researchers

Compounds derived from plant-based sources - including garlic, broccoli and medicine plants - confer protective effects against breast cancer, explain researchers at the University of Pittsburgh Cancer Institute (UPCI), partner with the UPMC CancerCenter.

7 Apr 2014

Deciphera Pharmaceuticals initiates Phase 1 clinical trial of pan-RAF inhibitor LY3009120

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7 Apr 2014

Research suggests NEDD9 scaffolding protein activates oncogenic signaling pathways in cancer cells, encourages metastases

Researchers from Fox Chase Cancer Center have shown that NEDD9, a scaffolding protein responsible for regulating signaling pathways in the cell, promotes the growth and spread of epithelial ovarian cancer.

7 Apr 2014

Wistar findings suggest link between colon microbiome and genome stability

Colorectal cancer develops in what is probably the most complex environment in the human body, a place where human cells cohabitate with a colony of approximately 10 trillion bacteria, most of which are unknown.

7 Apr 2014

Protein C News and Research

Scientists uncover surprising link between brain development and gene tied to breast cancer

Study shows subpopulations of breast cancer cells cooperate to aid tumor growth

Production of Immutep’s ImmuFact IMP321 starts at WuXi AppTec facilities in China

Study: VISTA deficiency leads to enhanced immune activation

PeptiDream develops novel macrocyclic peptide inhibitor for treatment of multiple influenza strains

Research to understand exactly how bleach kills bacteria

Researchers show Elafin protein plays key role against inflammatory reaction typical of celiac disease

TSRI reveals new aspects of more potent anti-diabetic drugs with fewer serious side effects

Magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment

NRAS gene that plays fundamental role in cancer development produces five gene variants, says study

Genome Project offers new leads to improve outcomes for children with high-grade glioma brain tumors

Findings could lead to more potent anti-diabetic drugs with fewer side effects

UPCI/MWRI researchers to present results of immune gene profile exploring endometriosis and cancer

Caffeine has positive effect on tau deposits in Alzheimer's disease

TSRI scientists solve long-standing mystery about sense of touch

New insights provide novel therapeutic approach against cancer

Compounds from plant confer protective effects against breast cancer, say researchers

Deciphera Pharmaceuticals initiates Phase 1 clinical trial of pan-RAF inhibitor LY3009120

Research suggests NEDD9 scaffolding protein activates oncogenic signaling pathways in cancer cells, encourages metastases

Wistar findings suggest link between colon microbiome and genome stability

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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