Genetic Engineering News and Research

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Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop. In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process.

16 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Study shortlists potential drug repurposing candidates to treat symptoms in ASD

Can you teach an old drug new tricks? Although drug treatments for the core symptoms of autism spectrum disorder (ASD) are not currently available, could an existing drug provide a new treatment, even if it previously had no association with ASD? This was the question asked by a new study in the journal Frontiers in Pharmacology. The researchers used a computer model that encompasses proteins involved in ASD and the way they interact.

12 Sep 2022

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

The immune system is equipped to respond not just to external invaders - think viruses, bacteria, and parasites - but also to internal threats, namely, cancer. Yet, frequently, malignancies overcome the immune system's defenses and evade detection.

12 Sep 2022

Booster vaccination maintains high efficacy against malaria in African children

Researchers from the University of Oxford and their partners have today reported new findings from their Phase 2b trial following the administration of a booster dose of the candidate malaria vaccine, R21/Matrix-M™ - which previously demonstrated high-level efficacy of 77% over the following 12 months in young west African children in 2021.

9 Sep 2022

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Energy supply is a vital component of economic life. And the complex interplay between society and economy is jeopardized whenever core services or key industrial sectors are at risk of failing because of energy supply problems.

7 Sep 2022

First nasal vaccine for COVID-19 approved in India for emergency use

The world's first nasal vaccine for COVID-19 was approved Tuesday, Sept. 6, in India for emergency use. The vaccine, called iNCOVACC, is based on technology licensed from Washington University in St. Louis and developed in collaboration with Bharat Biotech International Limited in India.

7 Sep 2022

Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.

6 Sep 2022

The brain and fat communicate directly

Researchers examine the sensory innervation of fat cells within subcutaneous fat deposits.

4 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Cell-based immunotherapy called CAR-T cell therapy has revolutionized the treatment of several cancers.

1 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Study uncovers molecular changes in the brain’s blood vessels caused by Alzheimer’s susceptibility gene

Recent breakthroughs have revealed a great deal about Alzheimer's disease, but researchers have yet to paint a complete picture of how genetic risk for the illness causes the brain damage that ultimately leads to memory loss and cognitive decline.

30 Aug 2022

NRL fungal experiment to launch as part of NASA's scheduled Artemis I mission

An experiment prepared by the U.S. Naval Research Laboratory (NRL) will launch as part of NASA's scheduled Artemis I mission to orbit the moon Aug. 29.

26 Aug 2022

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications.

25 Aug 2022

COVID-19 pandemic: An epidemiological update

Epidemics and pandemics have been frightening the human chase again and again. SARS, H1N1, Ebola, and more have exposed their real face in the past, but with every such outbreak.

25 Aug 2022

Experimental, genetically attenuated malaria vaccine warrants further exploration

Findings from a preliminary human study of an experimental, genetically attenuated malaria parasite immunization show this vaccine warrants further exploration.

24 Aug 2022

“Drug factory” implants show promise in eradicating mesothelioma tumors

Rice University and Baylor College of Medicine researchers have shown they can eradicate advanced-stage mesothelioma tumors in mice in just a few days with a treatment combining Rice's cytokine "drug factory" implants and a checkpoint inhibitor drug.

22 Aug 2022

Researchers discover how patients with mutations in a DNA sequence develop pancreatic malformations

Researchers at the Centre for Genomic Regulation have identified a DNA sequence that is crucial for pancreatic differentiation and function – and for the first time – describe how it works.

22 Aug 2022

Genetic Engineering News and Research

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Blocking FNDC5 prevents cancer-induced cachexia in mice

Study shortlists potential drug repurposing candidates to treat symptoms in ASD

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

Booster vaccination maintains high efficacy against malaria in African children

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

First nasal vaccine for COVID-19 approved in India for emergency use

Lactate may have a previously unrecognized role in fighting cancer

The brain and fat communicate directly

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Study uncovers molecular changes in the brain’s blood vessels caused by Alzheimer’s susceptibility gene

NRL fungal experiment to launch as part of NASA's scheduled Artemis I mission

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

COVID-19 pandemic: An epidemiological update

Experimental, genetically attenuated malaria vaccine warrants further exploration

“Drug factory” implants show promise in eradicating mesothelioma tumors

Researchers discover how patients with mutations in a DNA sequence develop pancreatic malformations

eBook: Using iPSCs models for human disease research and drug discovery eBook

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