Immunohistochemistry News and Research

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Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

Digital spatial profiling of individual glomeruli from HIV and COVID-19 patients

Now, a new study posted to the bioRxiv* server by scientists from the University of Washington explores the use of NanoString’s GeoMx digital spatial profiling (DSP) to investigate CG caused by HIV and SARS-Cov-2 infections.

14 Sep 2021

Age-related differences in immune dynamics in rhesus macaques infected with SARS-CoV-2

In a recent study, authors explore the relationship between age and immune response to COVID-19.

13 Sep 2021

Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

Scientists from the National Institutes of Health, USA, have recently demonstrated the immunogenicity and protective efficacy of two vesicular stomatitis virus (VSV)-based coronavirus disease 2019 (COVID-19) vaccines in hamsters.

6 Sep 2021

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

A new study published in mBio investigates the impact of the furin cleavage site on viral growth and pathogenesis.

31 Aug 2021

Study offers hope for an era of safer chemotherapy in breast cancer

Breast cancer is the deadliest and most common type of cancer in women. The treatment options often require administration of anti-cancer drugs in high doses, as the cells develop resistance towards chemotherapy, leading to painful side effects in patients.

23 Aug 2021

Study in dogs may lead to better understanding of how gliomas affect the immune system

A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas.

20 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

Researchers discuss the relationship between airway neutrophils and SARS-CoV-2 infection to determine the impact that neutrophils have on COVID-19.

15 Aug 2021

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Immunohistochemistry staining showing PD1 expression on tumor cells in a skin biopsy from a cutaneous T-cell lymphoma patient.

5 Aug 2021

Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

Scientists evaluate the use of ChAdOx1 nCoV-19 as a potential intranasal (IN) vaccine candidate in hamster and rhesus macaque models.

3 Aug 2021

New molecular and morphologic insights into chronic rejection after lung transplantation

A study of lung tissue from patients with end-stage bronchiolitis obliterans syndrome (BOS) as a complication of lung transplantation yielded molecular and morphologic insights into the development of chronic rejection.

3 Aug 2021

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

One of the major challenges in modern cancer therapy is the adaptive response of cancer cells to targeted therapies: initially, these therapies are very often effective, then adaptive resistance occurs, allowing the tumor cells to proliferate again.

21 Jul 2021

SARS-CoV-2 variants show distinct humoral response and transcriptional profiles in hamster model

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel, highly infectious respiratory virus, and the causative agent of coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2, which first originated in Wuhan, in Hubei province of China, is a member of the Coronavirdae family and has a large, non-segmented RNA genome.

14 Jul 2021

SARS-CoV-2 infects and replicates in the salivary glands, study finds

In Brazil, researchers at the University of São Paulo's Medical School (FM-USP) have discovered that SARS-CoV-2 infects and replicates in the salivary glands.

6 Jul 2021

COVID-19 patients suffer from cognitive, behavioral problems after discharge, study finds

COVID-19 patients suffer from cognitive and behavioral problems two months after being discharged from hospital, a new study presented at the 7th Congress of the European Academy of Neurology (EAN) has found.

21 Jun 2021

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent.

1 Jun 2021

Neuropathology of COVID-19 patients caused by infection of brain pericytes

Recently, researchers from the UK and Sweden used highly sensitive multiplexed immunohistochemistry to study the brain tissue of COVID-19 patients and controls to analyze ACE2 expression in brain pericytes of patients with neurological symptoms. They also used spatial immunophenotyping to assess inflammation in brain tissue of COVID-19 patients.

31 May 2021

New book provides insight into the pathophysiology of leprosy

Leprosy remains one of the biggest public health problems in many countries. It is a complex disease in several aspects, including clinical, histopathological, and molecular.

29 May 2021

Adaptimmune to report Phase 2 trial data on synovial sarcoma at ASCO congress

Adaptimmune Therapeutics plc, a leader in cell therapy to treat cancer, will report initial data from its Phase 2 SPEARHEAD-1 trial, with afamitresgene autoleucel (afami-cel, formerly ADP-A2M4), at the American Society of Clinical Oncology (ASCO) congress. Full abstracts were released online today.

21 May 2021

Immunohistochemistry News and Research

Further Reading

Digital spatial profiling of individual glomeruli from HIV and COVID-19 patients

Age-related differences in immune dynamics in rhesus macaques infected with SARS-CoV-2

Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

Study offers hope for an era of safer chemotherapy in breast cancer

Study in dogs may lead to better understanding of how gliomas affect the immune system

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

New molecular and morphologic insights into chronic rejection after lung transplantation

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

SARS-CoV-2 variants show distinct humoral response and transcriptional profiles in hamster model

SARS-CoV-2 infects and replicates in the salivary glands, study finds

COVID-19 patients suffer from cognitive, behavioral problems after discharge, study finds

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Neuropathology of COVID-19 patients caused by infection of brain pericytes

New book provides insight into the pathophysiology of leprosy

Adaptimmune to report Phase 2 trial data on synovial sarcoma at ASCO congress

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